Search Results - "CARBONE, D. P"

Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim by Konishi, J, Yi, F, Chen, X, Vo, H, Carbone, D P, Dang, T P

“…Notch signaling is a highly conserved pathway important for normal embryonic development and cancer. We previously demonstrated a role for Notch3 in lung…”
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Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches by Reck, M., Carbone, D.P., Garassino, M., Barlesi, F.

“…Rat sarcoma (RAS) is the most frequently mutated oncogene in human cancer, with Kirsten rat sarcoma (KRAS) being the most commonly mutated RAS isoform…”
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Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts by Min, Y, Adachi, Y, Yamamoto, H, Imsumran, A, Arimura, Y, Endo, T, Hinoda, Y, Lee, C-T, Nadaf, S, Carbone, D P, Imai, K

“…Background and aims: Insulin-like growth factor (IGF) I receptor (IGF-Ir) signalling is required for carcinogenicity and proliferation of many tumours but this…”
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Decreased antigen presentation by dendritic cells in patients with breast cancer by GABRILOVICH, D. I, CORAK, J, CIERNIK, I. F, KAVANAUGH, D, CARBONE, D. P

“…We evaluated T-cell responses to mitogens and to defined antigens in breast cancer patients. Significant defects in responses to tetanus toxoid and influenza…”
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Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer by Almand, Bond, Clark, Joseph I, Nikitina, Ekaterina, van Beynen, James, English, Nicholas R, Knight, Stella C, Carbone, David P, Gabrilovich, Dmitry I

“…Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control…”
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Chromosome 19 Translocation, Overexpression of Notch3, and Human Lung Cancer by Dang, Thao P., Gazdar, Adi F., Virmani, Arvind K., Sepetavec, Tanya, Hande, Kenneth R., Minna, John D., Roberts, John R., Carbone, David P.

“…In contrast, Notch3 messenger RNA was highly expressed in the HCC2429 cell line (Fig. 1, d; lane 2). Expression of Notch3 was detected in frozen tumor tissue…”
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Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells by ANUMANTHAN, G, HALDER, S. K, OSADA, H, TAKAHASHI, T, MASSION, P. P, CARBONE, D. P, DATTA, P. K

“…Members of the transforming growth factor-beta (TGF-beta) family regulate a wide range of biological processes including cell proliferation, migration,…”
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Antibodies to Vascular Endothelial Growth Factor Enhance the Efficacy of Cancer Immunotherapy by Improving Endogenous Dendritic Cell Function by GABRILOVICH, D. I, ISHIDA, T, NADAF, S, OHM, J. E, CARBONE, D. P

“…Inadequate function of dendritic cells (DCs) in tumor-bearing hosts is one mechanism of tumor escape from immune system control and may compromise the efficacy…”
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Nuclear survivin as a biomarker for non-small-cell lung cancer by LU, B, GONZALEZ, A, MASSION, P. P, SHYR, Y, SHAKTOUR, B, CARBONE, D. P, HALLAHAN, D. E

“…Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with…”
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First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update by Reck, M., Ciuleanu, T.-E., Cobo, M., Schenker, M., Zurawski, B., Menezes, J., Richardet, E., Bennouna, J., Felip, E., Juan-Vidal, O., Alexandru, A., Sakai, H., Lingua, A., Reyes, F., Souquet, P.-J., De Marchi, P., Martin, C., Pérol, M., Scherpereel, A., Lu, S., Paz-Ares, L., Carbone, D.P., Memaj, A., Marimuthu, S., Zhang, X., Tran, P., John, T.

“…To further characterize survival benefit with first-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone, we report updated…”
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Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro by Haruki, N, Kawaguchi, K S, Eichenberger, S, Massion, P P, Gonzalez, A, Gazdar, A F, Minna, J D, Carbone, D P, Dang, T P

“…Background: Somatically acquired chromosomal translocation is a common mechanism of oncogene activation in many haematopoietic tumours and sarcomas. However,…”
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Newly diagnosed patients with advanced non-small cell lung cancer: A clinical description of those with moderate to severe depressive symptoms by Andersen, B.L., Valentine, T.R., Lo, S.B., Carbone, D.P., Presley, C.J., Shields, P.G.

“…•Advanced NSCLC patients reported moderate/severe depressive symptoms at diagnosis.•Severely depressed patients had the highest suicidality, hopelessness,…”
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The biology of lung cancer by Carbone, D P

“…Lung cancer is the most common cause of cancer death in the United States among both men and women, with an estimated 177,000 new cases and 159,000 deaths in…”
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LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells by Whang, Y M, Park, S I, Trenary, I A, Egnatchik, R A, Fessel, J P, Kaufman, J M, Carbone, D P, Young, J D

“…The tumor suppressor serine/threonine kinase 11 ( STK11 or LKB1 ) is mutated in 20–30% of patients with non-small-cell lung cancer (NSCLC). Loss of…”
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Dendritic cells transduced with wild‐type p53 gene elicit potent anti‐tumour immune responses by ISHIDA, T, CHADA, S, STIPANOV, M, NADAF, S, CIERNIK, F. I, GABRILOVICH, D. I, CARBONE, D. P

“…In this study we have tested the concept of using wild‐type p53 gene for immunotherapy of cancer. Dendritic cells (DC) were transduced with a human wild‐type…”
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Genomic characterization of thymic epithelial tumors in a real-world dataset by Kurokawa, K., Shukuya, T., Greenstein, R.A., Kaplan, B.G., Wakelee, H., Ross, J.S., Miura, K., Furuta, K., Kato, S., Suh, J., Sivakumar, S., Sokol, E.S., Carbone, D.P., Takahashi, K.

“…Thymic epithelial tumors (TETs) are rare neoplasms arising in the mediastinum, including thymic carcinomas and thymomas. Due to their rarity, little is known…”
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Immune related adverse events across cancer types: Incidence, risk factors and survival by Owen, D.H., Burkart, J., Patel, S., Wei, L., Tinoco, G., Liebner, D., He, K., Shields, P.G., Bertino, E.M., Presley, C.J., Johns, A., Folefac, E., Olencki, T., Carbone, D.P., Verschraegen, C., Otterson, G.A., Kendra, K.L.

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A Phase I Single-Dose Trial of Gadolinium Texaphyrin (Gd-Tex), a Tumor Selective Radiation Sensitizer Detectable by Magnetic Resonance Imaging by ROSENTHAL, D. I, NURENBERG, P, RENSCHLER, M. F, BECERRA, C. R, FRENKEL, E. P, CARBONE, D. P, LUM, B. L, MILLER, R, ENGEL, J, YOUNG, S, MILES, D

“…Gadolinium Texaphyrin (Gd-Tex) is a radiation sensitizer with a novel mechanism of action that sensitizes both oxic and hypoxic cells, localizes selectively in…”
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Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis by Yang, Li, DeBusk, Laura M., Fukuda, Koari, Fingleton, Barbara, Green-Jarvis, Brenda, Shyr, Yu, Matrisian, Lynn M., Carbone, David P., Lin, P.Charles

“…We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+CD11b+ cells, which are evident in cancer patients and tumor-bearing animals. These…”
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A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer by Chen, Hailei L, Nadaf, Sorena, Girgis, Khaled R, Gabrilovich, Dmitry, Carbone, David P, Tampé, Robert

“…Tumours express a variety of novel epitopes which represent potential immune targets, and thus clinically evident tumours are thought to have effectively…”
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