Search Results - "CARAS, Ingrid"

Two cancer stem cell‐targeted therapies in clinical trials as viewed from the standpoint of the cancer stem cell model by Caras, Ingrid W.

“…A key implication of the cancer stem cell model is that for a cancer therapy to be curative, it is imperative to eliminate the cancer stem cells (CSCs) that…”
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A stem cell journey in ophthalmology: From the bench to the clinic by Caras, Ingrid W., Collins, Lila R., Creasey, Abla A.

“…Debilitating diseases of the eye represent a large unmet medical need potentially addressable with stem cell‐based approaches. Over the past decade, the…”
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Proceedings: Moving Toward Cell‐Based Therapies for Heart Disease by Collins, Lila R., Priest, Catherine, Caras, Ingrid, Littman, Neil, Kadyk, Lisa

“…Heart attack and the heart failure that often follows represent an enormous financial burden and unmet medical need. The cell therapy and tissue‐engineering…”
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Proceedings: Debilitating Eye Diseases by Caras, Ingrid W., Littman, Neil, Abo, Arie

“…Debilitating eye diseases such as age‐related macular degeneration and retinitis pigmentosa currently represent a large unmet medical need that could…”
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Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages by Punturieri, A, Filippov, S, Allen, E, Caras, I, Murray, R, Reddy, V, Weiss, S J

“…Human macrophages mediate the dissolution of elastic lamina by mobilizing tissue-destructive cysteine proteinases. While macrophage-mediated elastin…”
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Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer by HENSHALL, Susan M, AFAR, Daniel E. H, QUINN, David I, TURNER, Jennifer J, DELPRADO, Warick, LEE, C-Soon, GOLOVSKY, David, BRENNER, Phillip C, O'NEILL, Gordon F, KOONER, Raji, STRICKER, Phillip D, GRYGIEL, John J, RASIAH, Krishan K, MACK, David H, SUTHERLAND, Robert L, HORVATH, Lisa G, GISH, Kurt, CARAS, Ingrid, RAMAKRISHNAN, Vanitha, WONG, Melanie, JEFFRY, Ursula, KENCH, James G

“…We have utilized oligonucleotide microarrays to identify novel genes of potential clinical and biological importance in prostate cancer. RNA from 74 prostate…”
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Preclinical validation of anti-TMEFF2-auristatin E–conjugated antibodies in the treatment of prostate cancer by Afar, Daniel E H, Bhaskar, Vinay, Ibsen, Eric, Breinberg, Danna, Henshall, Susan M, Kench, James G, Drobnjak, Marija, Powers, Rick, Wong, Melanie, Evangelista, Ferdinand, O'Hara, Chris, Powers, David, DuBridge, Robert B, Caras, Ingrid, Winter, Ruth, Anderson, Terri, Solvason, Nanette, Stricker, Phillip D, Cordon-Cardo, Carlos, Scher, Howard I, Grygiel, John J, Sutherland, Robert L, Murray, Richard, Ramakrishnan, Vanitha, Law, Debbie A

“…Current treatments for advanced stage, hormone-resistant prostate cancer are largely ineffective, leading to high patient mortality and morbidity. To fulfill…”
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Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation by Winslow, John W, Moran, Paul, Valverde, Janet, Shih, Ai, Yuan, Jean O, Wong, Suzy C, Tsai, Siao Ping, Goddard, Audrey, Henzel, William J, Hefti, Franz, Beck, Klaus D, Caras, Ingrid W

“…REK7 is an Eph-related tyrosine kinase receptor expressed exclusively in the nervous system, predominantly in hippocampus and cortex. A soluble REK7-IgG fusion…”
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Requirements for Glycosylphosphatidylinositol Attachment Are Similar but Not Identical in Mammalian Cells and Parasitic Protozoa by Moran, Paul, Caras, Ingrid W.

“…The general features of the glycosylphosphatidylinositol (GPI) signal have been conserved in evolution. To test whether the requirements for GPI attachment are…”
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AL-1-induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton by Meima, Leonie, Kljavin, Ivar J., Moran, Paul, Shih, Ai, Winslow, John W., Caras, Ingrid W.

“…Previous experiments identified AL‐1 as a glycosylphosphatidylinositol (GPI)‐linked ligand for the Eph‐related receptor, REK7, and showed that a REK7‐IgG…”
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Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by Tai, Yu-Tzu, Dillon, Myles, Song, Weihua, Leiba, Merav, Li, Xian-Feng, Burger, Peter, Lee, Alfred I., Podar, Klaus, Hideshima, Teru, Rice, Audie G., van Abbema, Anne, Jesaitis, Lynne, Caras, Ingrid, Law, Debbie, Weller, Edie, Xie, Wanling, Richardson, Paul, Munshi, Nikhil C., Mathiot, Claire, Avet-Loiseau, Hervé, Afar, Daniel E.H., Anderson, Kenneth C.

“…Currently, no approved monoclonal antibody (mAb) therapies exist for human multiple myeloma (MM). Here we characterized cell surface CS1 as a novel MM antigen…”
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Glycosylphosphatidylinositol-Anchored Proteins Are Preferentially Targeted to the Basolateral Surface in Fischer Rat Thyroid Epithelial Cells by Zurzolo, Chiara, Lisanti, Michael P., Caras, Ingrid W., Nitsch, Lucio, Rodriguez-Boulan, Enrique

“…Glycosylphosphatidylinositol (GPI) acts as an apical targeting signal in MDCK cells and other kidney and intestinal cell lines. In striking contrast with these…”
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Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins by Caras, Ingrid W, Davitz, Michael A, Rhee, Lucy, Weddell, Greg, Martin, David W, Nussenzweig, Victor

“…Decay-accelerating factor (DAF), a glycoprotein that is anchored to the cell membrane by phosphatidylinositol, binds activated complement fragments C3b and…”
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Anti-CSl humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by TAI, Yu-Tzu, DILLON, Myles, VAN ABBEMA, Anne, JESAITIS, Lynne, CARAS, Ingrid, LAW, Debbie, WELLER, Edie, WANLING XIE, RICHARDSON, Paul, MUNSHI, Nikhil C, MATHIOT, Claire, AVET-LOISEAU, Hervé, WEIHUA SONG, AFAR, Daniel E. H, ANDERSON, Kenneth C, LEIBA, Merav, LI, Xian-Feng, BURGER, Peter, LEE, Alfred I, PODAR, Klaus, HIDESHIMA, Teru, RICE, Audie G

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Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor by Caras, Ingrid W., Weddell, Gregory N., Davitz, Michael A., Nussenzweig, Victor, Martin, David W.

“…Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is…”
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Signal Peptide for Protein Secretion Directing Glycophospholipid Membrane Anchor Attachment by Caras, Ingrid W., Weddell, Gregory N.

“…Decay accelerating factor (DAF) is anchored to the plasma membrane by a glycophospholipid (GPI) membrane anchor covalently attached to the COOH-terminus of the…”
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Csk and BatK Show Opposite Temporal Expression in the Rat CNS: Consistent with its Late Expression in Development, BatK Induces Differentiation of PC12 Cells by Kuo, Sophia S., Armanini, Mark P., Phillips, Heidi S., Caras, Ingrid W.

“…BatK is a second member of the Csk family of regulatory kinases that phosphorylate a key inhibitory tyrosine on Src family kinases, leading to down‐regulation…”
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Determining subcellular localization of novel drug targets by transient transfection in COS cells by SIMON, Iris, WRIGHT, Meredith, FLOHR, Tanya, HEVEZI, Peter, CARAS, Ingrid W

“…Genomics-based approaches are increasingly being used to identify disease-associated genes that represent potential new drug targets. As a first step in the…”
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Protein targeting in the analysis of learning and memory : a potential alternative to gene targeting by GERLAI, R, WILLIAMS, S. P, CAIRNS, B, VAN BRUGGEN, N, MORAN, P, SHIH, A, CARAS, I, SAUER, H, PHILLIPS, H. S, WINSLOW, J. W

“…Gene targeting using homologous recombination in embryonic stem (ES) cells offers unprecedented precision with which one may manipulate single genes and…”
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Lerk2 (Ephrin-B1) Is a Collapsing Factor for a Subset of Cortical Growth Cones and Acts by a Mechanism Different from AL-1 (Ephrin-A5) by Meima, Leonie, Moran, Paul, Matthews, William, Caras, Ingrid W.

“…The transmembrane (TM) subfamily of Eph ligands and their receptors have been implicated in axon pathfinding and in pattern formation during embryogenesis…”
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