Search Results - "CARANO, Richard A"

Bv8 regulates myeloid-cell-dependent tumour angiogenesis by Ferrara, Napoleone, Shojaei, Farbod, Wu, Xiumin, Zhong, Cuiling, Yu, Lanlan, Liang, Xiao-Huan, Yao, Jenny, Blanchard, Dominique, Bais, Carlos, Peale, Franklin V, van Bruggen, Nicholas, Ho, Calvin, Ross, Jed, Tan, Martha, Carano, Richard A. D, Meng, Y. Gloria

“…Bone-marrow-derived cells facilitate tumour angiogenesis, but the molecular mechanisms of this facilitation are incompletely understood. We have previously…”
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Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks by Jemaa, Skander, Fredrickson, Jill, Carano, Richard A. D., Nielsen, Tina, de Crespigny, Alex, Bengtsson, Thomas

“…18 F-Fluorodeoxyglucose-positron emission tomography (FDG-PET) is commonly used in clinical practice and clinical drug development to identify and quantify…”
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Mature Dendritic Cells Use Endocytic Receptors to Capture and Present Antigens by Platt, Craig D., Ma, Jessica K., Chalouni, Cécile, Ebersold, Melanie, Bou-Reslan, Hani, Carano, Richard A. D., Mellman, Ira, Delamarre, Lélia, Steinman, Ralph M.

“…In response to inflammatory stimuli, dendritic cells (DCs) trigger the process of maturation, a terminal differentiation program required to initiate…”
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Multi-arm U-Net with dense input and skip connectivity for T2 lesion segmentation in clinical trials of multiple sclerosis by Krishnan, Anitha Priya, Song, Zhuang, Clayton, David, Jia, Xiaoming, de Crespigny, Alex, Carano, Richard A. D.

“…T2 lesion quantification plays a crucial role in monitoring disease progression and evaluating treatment response in multiple sclerosis (MS). We developed a…”
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Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia by Wu, Ai-Luen, Feng, Bo, Chen, Mark Z, Kolumam, Ganesh, Zavala-Solorio, Jose, Wyatt, Shelby K, Gandham, Vineela D, Carano, Richard A D, Sonoda, Junichiro

“…The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate…”
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Deep Ensembles Are Robust to Occasional Catastrophic Failures of Individual DNNs for Organs Segmentations in CT Images by Petrov, Yury, Malik, Bilal, Fredrickson, Jill, Jemaa, Skander, Carano, Richard A. D.

“…Deep neural networks (DNNs) have recently showed remarkable performance in various computer vision tasks, including classification and segmentation of medical…”
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Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies by Dejanovic, Borislav, Huntley, Melanie A., De Mazière, Ann, Meilandt, William J., Wu, Tiffany, Srinivasan, Karpagam, Jiang, Zhiyu, Gandham, Vineela, Friedman, Brad A., Ngu, Hai, Foreman, Oded, Carano, Richard A.D., Chih, Ben, Klumperman, Judith, Bakalarski, Corey, Hanson, Jesse E., Sheng, Morgan

“…Synapse loss and Tau pathology are hallmarks of Alzheimer’s disease (AD) and other tauopathies, but how Tau pathology causes synapse loss is unclear. We used…”
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Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology by Lee, Seung-Hye, Meilandt, William J., Xie, Luke, Gandham, Vineela D., Ngu, Hai, Barck, Kai H., Rezzonico, Mitchell G., Imperio, Jose, Lalehzadeh, Guita, Huntley, Melanie A., Stark, Kimberly L., Foreman, Oded, Carano, Richard A.D., Friedman, Brad A., Sheng, Morgan, Easton, Amy, Bohlen, Christopher J., Hansen, David V.

“…Loss-of-function TREM2 mutations strongly increase Alzheimer’s disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models…”
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Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor by Seidel, Kerstin, Ahn, Christina P, Lyons, David, Nee, Alexander, Ting, Kevin, Brownell, Isaac, Cao, Tim, Carano, Richard A D, Curran, Tom, Schober, Markus, Fuchs, Elaine, Joyner, Alexandra, Martin, Gail R, de Sauvage, Frederic J, Klein, Ophir D

“…In many organ systems such as the skin, gastrointestinal tract and hematopoietic system, homeostasis is dependent on the continuous generation of…”
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Death Receptors DR6 and TROY Regulate Brain Vascular Development by Tam, Stephen J., Richmond, David L., Kaminker, Joshua S., Modrusan, Zora, Martin-McNulty, Baby, Cao, Tim C., Weimer, Robby M., Carano, Richard A.D., van Bruggen, Nick, Watts, Ryan J.

“…Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By…”
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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models by Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D

“…Genetically engineered mouse models of cancer simulate the spontaneous development of tumors in their native tissue environment. Singh et al . establish their…”
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Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation by Long, Jason E., Wongchenko, Matthew J., Nickles, Dorothee, Chung, Wei-Jen, Wang, Bu-er, Riegler, Johannes, Li, Ji, Li, Qingling, Sandoval, Wendy, Eastham-Anderson, Jeff, Modrusan, Zora, Junttila, Teemu, Carano, Richard A. D., Foreman, Oded, Yan, Yibing, Junttila, Melissa R.

“…Emerging research suggests that multiple tumor compartments can influence treatment responsiveness and relapse, yet the search for therapeutic resistance…”
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Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection by Carlsson, Fredric, Kim, Janice, Dumitru, Calin, Barck, Kai H, Carano, Richard A D, Sun, Mei, Diehl, Lauri, Brown, Eric J

“…The Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular…”
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Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies by Gong, Yan, Bourhis, Eric, Chiu, Cecilia, Stawicki, Scott, DeAlmeida, Venita I, Liu, Bob Y, Phamluong, Khanhky, Cao, Tim C, Carano, Richard A D, Ernst, James A, Solloway, Mark, Rubinfeld, Bonnee, Hannoush, Rami N, Wu, Yan, Polakis, Paul, Costa, Mike

“…β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the…”
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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease by Le Pichon, Claire E, Meilandt, William J, Dominguez, Sara, Solanoy, Hilda, Lin, Han, Ngu, Hai, Gogineni, Alvin, Sengupta Ghosh, Arundhati, Jiang, Zhiyu, Lee, Seung-Hye, Maloney, Janice, Gandham, Vineela D, Pozniak, Christine D, Wang, Bei, Lee, Sebum, Siu, Michael, Patel, Snahel, Modrusan, Zora, Liu, Xingrong, Rudhard, York, Baca, Miriam, Gustafson, Amy, Kaminker, Josh, Carano, Richard A D, Huang, Eric J, Foreman, Oded, Weimer, Robby, Scearce-Levie, Kimberly, Lewcock, Joseph W

“…Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these…”
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USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma by Williams, Samuel A., Maecker, Heather L., French, Dorothy M., Liu, Jinfeng, Gregg, Andrew, Silverstein, Leah B., Cao, Tim C., Carano, Richard A.D., Dixit, Vishva M.

“…Inhibitors of DNA binding (IDs) antagonize basic-helix-loop-helix (bHLH) transcription factors to inhibit differentiation and maintain stem cell fate. ID…”
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Clinical translation of ferumoxytol‐based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population by Fredrickson, Jill, Serkova, Natalie J., Wyatt, Shelby K., Carano, Richard A.D., Pirzkall, Andrea, Rhee, Ina, Rosen, Lee S., Bessudo, Alberto, Weekes, Colin, de Crespigny, Alex

“…Purpose To assess the feasibility of acquiring vessel size imaging (VSI) metrics using ferumoxytol injections and stock pulse sequences in a multicenter Phase…”
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Heart and bladder detection and segmentation on FDG PET/CT by deep learning by Wang, Xiaoyong, Jemaa, Skander, Fredrickson, Jill, Coimbra, Alexandre Fernandez, Nielsen, Tina, De Crespigny, Alex, Bengtsson, Thomas, Carano, Richard A D

“…Positron emission tomography (PET)/ computed tomography (CT) has been extensively used to quantify metabolically active tumors in various oncology indications…”
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Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor by Keshari, Kayvan R., Wilson, David M., Van Criekinge, Mark, Sriram, Renuka, Koelsch, Bertram L., Wang, Zhen J., VanBrocklin, Henry F., Peehl, Donna M., O'Brien, Tom, Sampath, Deepak, Carano, Richard A. D., Kurhanewicz, John

“…BACKGROUND Metabolic shifts in disease are of great interest for the development of novel therapeutics. In cancer treatment, these therapies exploit the…”
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Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse by Wilson, Deanna G, Phamluong, Khanhky, Li, Li, Sun, Mei, Cao, Tim C, Liu, Peter S, Modrusan, Zora, Sandoval, Wendy N, Rangell, Linda, Carano, Richard A D, Peterson, Andrew S, Solloway, Mark J

“…Melanoma inhibitory activity member 3 (MIA3/TANGO1) [corrected] is an evolutionarily conserved endoplasmic reticulum resident transmembrane protein. Recent in…”
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