Search Results - "CAPURRO, Valeria"

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules by Stravalaci, Matteo, Pagani, Isabel, Paraboschi, Elvezia Maria, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N., Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Invernizzi, Pietro, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Asselta, Rosanna, Vicenzi, Elisa, Mantovani, Alberto, Garlanda, Cecilia

“…The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus…”
Get full text

Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism by Sala, Mariaelvina, Braida, Daniela, Lentini, Daniela, Busnelli, Marta, Bulgheroni, Elisabetta, Capurro, Valeria, Finardi, Annamaria, Donzelli, Andrea, Pattini, Linda, Rubino, Tiziana, Parolaro, Daniela, Nishimori, Katsuhiko, Parenti, Marco, Chini, Bice

“…Background Oxytocin (OT) has been suggested as a treatment to improve social behavior in autistic patients. Accordingly, the OT ( Oxt −/− ) and the OT receptor…”
Get full text

Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment by Capurro, Valeria, Tomati, Valeria, Sondo, Elvira, Renda, Mario, Borrelli, Anna, Pastorino, Cristina, Guidone, Daniela, Venturini, Arianna, Giraudo, Alessandro, Mandrup Bertozzi, Sine, Musante, Ilaria, Bertozzi, Fabio, Bandiera, Tiziano, Zara, Federico, Galietta, Luis J. V., Pedemonte, Nicoletta

“…Deletion of phenylalanine at position 508 (F508del) in the CFTR chloride channel is the most frequent mutation in cystic fibrosis (CF) patients. F508del…”
Get full text

SUMOylation Inhibition Enhances Protein Transcription under CMV Promoter: A Lesson from a Study with the F508del-CFTR Mutant by Borgo, Christian, D'Amore, Claudio, Capurro, Valeria, Tomati, Valeria, Pedemonte, Nicoletta, Bosello Travain, Valentina, Salvi, Mauro

“…Cystic fibrosis (CF) is a genetic disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator ( ), a selective…”
Get full text

Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene by Venturini, Arianna, Borrelli, Anna, Musante, Ilaria, Scudieri, Paolo, Capurro, Valeria, Renda, Mario, Pedemonte, Nicoletta, Galietta, Luis J V

“…Cystic fibrosis (CF) is caused by loss of function of the CFTR chloride channel. A substantial number of CF patients carry nonsense mutations in the gene…”
Get full text

Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish by Braida, Daniela, Donzelli, Andrea, Martucci, Roberta, Capurro, Valeria, Busnelli, Marta, Chini, Bice, Sala, Mariaelvina

“…Rationale O xytocin (OT) and arginine-vasopressin (AVP) regulate social behavior in mammals. Zebrafish ( Danio rerio ) allows higher throughput and ease in…”
Get full text

The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs by Sondo, Elvira, Cresta, Federico, Pastorino, Cristina, Tomati, Valeria, Capurro, Valeria, Pesce, Emanuela, Lena, Mariateresa, Iacomino, Michele, Baffico, Ave Maria, Coviello, Domenico, Bandiera, Tiziano, Zara, Federico, Galietta, Luis J V, Bocciardi, Renata, Castellani, Carlo, Pedemonte, Nicoletta

“…Loss-of-function mutations of the gene cause cystic fibrosis (CF) through a variety of molecular mechanisms involving altered expression, trafficking, and/or…”
Get full text

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia by Gianotti, Ambra, Capurro, Valeria, Delpiano, Livia, Mielczarek, Marcin, García-Valverde, María, Carreira-Barral, Israel, Ludovico, Alessandra, Fiore, Michele, Baroni, Debora, Moran, Oscar, Quesada, Roberto, Caci, Emanuela

“…Cystic fibrosis (CF) is a genetic disease characterized by the lack of cystic fibrosis transmembrane conductance regulator (CFTR) protein expressed in…”
Get full text

Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators by Terlizzi, Vito, Pesce, Emanuela, Capurro, Valeria, Tomati, Valeria, Lena, Mariateresa, Pastorino, Cristina, Bocciardi, Renata, Zara, Federico, Centrone, Claudia, Taccetti, Giovanni, Castellani, Carlo, Pedemonte, Nicoletta

“…S737F is a Cystic Fibrosis (CF) transmembrane conductance regulator (CFTR) missense variant. The aim of our study was to describe the clinical features of a…”
Get full text

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity by Hernando, Elsa, Capurro, Valeria, Cossu, Claudia, Fiore, Michele, García-Valverde, María, Soto-Cerrato, Vanessa, Pérez-Tomás, Ricardo, Moran, Oscar, Zegarra-Moran, Olga, Quesada, Roberto

“…Anion selective ionophores, anionophores, are small molecules capable of facilitating the transmembrane transport of anions. Inspired in the structure of…”
Get full text

The Application of Bicarbonate Recovers the Chemical-Physical Properties of Airway Surface Liquid in Cystic Fibrosis Epithelia Models by Ferrera, Loretta, Capurro, Valeria, Delpiano, Livia, Gianotti, Ambra, Moran, Oscar

“…Cystic fibrosis (CF) is a genetic disease associated with the defective function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that…”
Get full text

Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease by Capurro, Valeria, Busquet, Perrine, Lopes, Joao Pedro, Bertorelli, Rosalia, Tarozzo, Glauco, Bolognesi, Maria Laura, Piomelli, Daniele, Reggiani, Angelo, Cavalli, Andrea

“…Alzheimer's disease (AD) is characterized by progressive loss of cognitive function, dementia and altered behavior. Over 30 million people worldwide suffer…”
Get full text

Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents by Braida, Daniela, Capurro, Valeria, Zani, Alessia, Rubino, Tiziana, Viganò, Daniela, Parolaro, Daniela, Sala, Mariaelvina

“…Background and purpose:  Drugs targeting brain κ‐opioid receptors produce profound alterations in mood. In the present study we investigated the possible…”
Get full text

Functional analysis of acid-activated Cl− channels: Properties and mechanisms of regulation by Capurro, Valeria, Gianotti, Ambra, Caci, Emanuela, Ravazzolo, Roberto, Galietta, Luis J.V., Zegarra-Moran, Olga

“…Cl− channels activated by acidic extracellular pH have been observed in various mammalian cells but their molecular identity and mechanisms of regulation are…”
Get full text

The mood stabilizing properties of AF3581, a novel potent GSK-3β inhibitor by Capurro, Valeria, Lanfranco, Massimiliano, Summa, Maria, Porceddu, Pier Francesca, Ciampoli, Mariasole, Margaroli, Natasha, Durando, Lucia, Garrone, Beatrice, Ombrato, Rosella, Tongiani, Serena, Reggiani, Angelo

“…[Display omitted] •The novel GSK-3β inhibitor AF3581 has remarkable stabilizing properties on mood cycling, in animal models of mood disorders.•AF3581…”
Get full text

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy by Cossu, Claudia, Fiore, Michele, Baroni, Debora, Capurro, Valeria, Caci, Emanuela, Garcia-Valverde, Maria, Quesada, Roberto, Moran, Oscar

“…Cystic fibrosis (CF) is a genetic lethal disease, originated from the defective function of the CFTR protein, a chloride and bicarbonate permeable…”
Get full text

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators by Tomati, Valeria, Capurro, Valeria, Pesce, Emanuela, Pastorino, Cristina, Sondo, Elvira, Lena, Mariateresa, Borrelli, Anna, Cresta, Federico, Pantano, Stefano, Collini, Francesca, Ripani, Pietro, Terlizzi, Vito, Fevola, Cristina, Costa, Stefano, Lucanto, Maria Cristina, Zara, Federico, Bandiera, Tiziano, Bocciardi, Renata, Castellani, Carlo, Galietta, Luis J. V., Pedemonte, Nicoletta

“…Introduction Cystic Fibrosis (CF) is a genetic disease due to loss-of-function mutations of the CFTR channel. F508del is the most frequent mutation (70% of…”
Get full text

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice by Busquet, Perrine, Capurro, Valeria, Cavalli, Andrea, Piomelli, Daniele, Reggiani, Angelo, Bertorelli, Rosalia

“…We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model…”
Get full text

Neuroprotective Effects of Genistein in Mongolian Gerbils: Estrogen Receptor–β Involvement by Donzelli, Andrea, Braida, Daniela, Finardi, Annamaria, Capurro, Valeria, Valsecchi, Anna Elisa, Colleoni, Mariapia, Sala, Mariaelvina

“…Genistein is a naturally occurring plant-derived phytoestrogen, present in the human diet, known to possess some beneficial effects. The present study…”
Get full text

CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium by Braccia, Clarissa, Christopher, Josie A, Crook, Oliver M, Breckels, Lisa M, Queiroz, Rayner M L, Liessi, Nara, Tomati, Valeria, Capurro, Valeria, Bandiera, Tiziano, Baldassari, Simona, Pedemonte, Nicoletta, Lilley, Kathryn S, Armirotti, Andrea

“…Cystic Fibrosis (CF) is a genetic disorder affecting around 1 in every 3000 newborns. In the most common mutation, F508del, the defective anion channel, CFTR,…”
Get full text