Search Results - "CAPRIOLI, Antonio"
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Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety
Published in PloS one (11-09-2015)“…Anxiety disorders are among the most prevalent psychiatric diseases with high personal costs and a remarkable socio-economic burden. However, current treatment…”
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2
The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations
Published in Neuroscience and Biobehavioral Reviews (01-11-2003)“…Attention-deficit hyperactivity disorder (ADHD) is a neuropsychiatric syndrome, affecting human infants and adolescents. Two main behavioural features are…”
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3
Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease
Published in Behavioural brain research (30-01-2005)“…Transgenic mouse models of Alzheimer’s disease (AD) have been recently advanced. Tg2576 mice have been shown to develop progressive β-amyloid (Aβ) neuritic…”
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4
Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice
Published in The Journal of pharmacology and experimental therapeutics (01-09-2008)“…A mouse model of atypical antipsychotic-associated adverse effects was used to compare the liability to induce weight gain, food intake, and metabolic…”
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5
Valproate and Acetyl-l-carnitine Prevent Methamphetamine-Induced Behavioral Sensitization in Mice
Published in Annals of the New York Academy of Sciences (01-12-2007)“…This study deals with the possible inhibitory role played by acetyl‐l‐carnitine (ALC) against methamphetamine (METH)‐induced behavioral sensitization. Because…”
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The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models
Published in The Journal of pharmacology and experimental therapeutics (01-07-2012)“…The effect of the enol carbamate 1-biphenyl-4-ylethenyl piperidine-1-carboxylate (ST4070), a novel reversible inhibitor of fatty acid amide hydrolase (FAAH),…”
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7
Sporadic Autonomic Dysregulation and Death Associated with Excessive Serotonin Autoinhibition
Published in Science (American Association for the Advancement of Science) (04-07-2008)“…Sudden infant death syndrome is the leading cause of death in the postneonatal period in developed countries. Postmortem studies show alterations in serotonin…”
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8
Non-native glyceraldehyde-3-phosphate dehydrogenase can be an intrinsic component of amyloid structures
Published in Biochimica et biophysica acta (01-12-2008)“…Interactions between different forms of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and amyloid-beta peptide (1–42) were investigated by direct (surface…”
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9
Social encounter with a novel partner in adolescent rats: Activation of the central endocannabinoid system
Published in Behavioural brain research (20-06-2011)“…► The endocannabinoid system is critically involved in social emotion. ► Striatal anandamide levels increased upon encounter with a novel partner. ►…”
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10
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases
Published in Journal of medicinal chemistry (09-08-2012)“…Fatty acid amide hydrolase (FAAH, EC 3.5.1.99) is the main enzyme catabolizing endocannabinoid fatty acid amides. FAAH inactivation promotes beneficial effects…”
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11
Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535)
Published in European journal of pharmacology (15-08-2015)“…Antagonism of the adenosine A2A receptor represents a promising strategy for non-dopaminergic treatment of Parkinson׳s disease (PD). Previously, the adenosine…”
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12
Litter Gender Composition Affects Maternal Behavior of the Primiparous Mouse Dam (Mus musculus )
Published in Journal of comparative psychology (1983) (01-03-1989)“…Thirty-nine litters of the outbred Swiss CD-1 mouse strain were reduced at birth to 6 pups, according to three conditions: MM (all males), MF (3 males and 3…”
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13
30 Days of Continuous Olanzapine Infusion Determines Energy Imbalance, Glucose Intolerance, Insulin Resistance, and Dyslipidemia in Mice
Published in Journal of clinical psychopharmacology (01-12-2009)“…The aim of this study was to model in mice the association between metabolic syndrome and the administration of atypical antipsychotic (AAP). Two dosages (4…”
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14
The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice
Published in Progress in neuro-psychopharmacology & biological psychiatry (01-07-2008)“…The reeler heterozygous (HZ) mice have provided a model for studying the relationship between reelin (a protein of extracellular matrix) haploinsufficiency and…”
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15
Spatial learning and memory in the radial maze: a longitudinal study in rats from 4 to 25 months of age
Published in Neurobiology of aging (01-09-1991)“…This longitudinal study was designed to investigate whether previous experience may influence performances and strategies of rats tested in the radial maze…”
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A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
Published in Bioorganic & medicinal chemistry letters (01-08-2010)“…A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the…”
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17
Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
Published in ChemMedChem (01-03-2010)“…FAAH inhibitors: This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high…”
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Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice
Published in Psychopharmacologia (01-05-2010)“…Rationale Neurons detect free fatty acids (FFAs) availability and use this nutritional status to modulate feeding and control body weight. Objectives The work…”
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19
An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain
Published in The Journal of pharmacology and experimental therapeutics (01-06-2012)“…Small peptides patterned after the N terminus of the synaptosomal protein of 25 kDa, a member of the protein complex implicated in Ca(2+)-dependent neuronal…”
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20
Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease
Published in Biochimica et biophysica acta (01-05-2007)“…Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the β-amyloid precursor protein (βAPP) in relationship with the…”
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