Search Results - "CAPRA, Valérie"

Transcellular biosynthesis of eicosanoid lipid mediators by Capra, Valérie, Rovati, G. Enrico, Mangano, Paolo, Buccellati, Carola, Murphy, Robert C., Sala, Angelo

“…The synthesis of oxygenated eicosanoids is the result of the coordinated action of several enzymatic activities, from phospholipase A2 that releases the…”
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The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor by Ciana, Paolo, Fumagalli, Marta, Trincavelli, Maria Letizia, Verderio, Claudia, Rosa, Patrizia, Lecca, Davide, Ferrario, Silvia, Parravicini, Chiara, Capra, Valérie, Gelosa, Paolo, Guerrini, Uliano, Belcredito, Silvia, Cimino, Mauro, Sironi, Luigi, Tremoli, Elena, Rovati, G Enrico, Martini, Claudia, Abbracchio, Maria P

“…Nucleotides and cysteinyl‐leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G‐protein‐coupled receptors: the…”
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Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents by Capra, Valérie, Rovati, G. Enrico

“…Abstract Background The concept of permanent narrowing of the airways resulting from chronic inflammation and fibrosis is called remodeling and is a common…”
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Eicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke by Capra, Valérie, Bäck, Magnus, Barbieri, Silvia S., Camera, Marina, Tremoli, Elena, Rovati, G. Enrico

“…Eicosanoids are biologically active lipids in both physiologic and pathophysiologic situations. These mediators rapidly generate at sites of inflammation and…”
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Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends by Capra, Valérie, Thompson, Miles D., Sala, Angelo, Cole, David E., Folco, Giancarlo, Rovati, G. Enrico

“…Cysteinyl‐leukotrienes (cysteinyl‐LTs), that is, LTC4, LTD4, and LTE4, trigger contractile and inflammatory responses through the specific interaction with G…”
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Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo by Capra, Valérie, Mauri, Mario, Guzzi, Francesca, Busnelli, Marta, Accomazzo, Maria Rosa, Gaussem, Pascale, Nisar, Shaista P., Mundell, Stuart J., Parenti, Marco, Rovati, G. Enrico

“…[Display omitted] Thromboxane A2 is a potent mediator of inflammation and platelet aggregation exerting its effects through the activation of a G…”
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The DRY motif and the four corners of the cubic ternary complex model by Rovati, G. Enrico, Capra, Valérie, Shaw, Vincent S., Malik, Rabia U., Sivaramakrishnan, Sivaraj, Neubig, Richard R.

“…Recent structural data on GPCRs using a variety of spectroscopic approaches suggest that GPCRs adopt a dynamic conformational landscape, with ligands…”
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Cysteinyl-leukotriene receptors and cellular signals by Rovati, G Enrico, Capra, Valérie

“…Cysteinyl-leukotrienes (cysteinyl-LTs) exert a range of proinflammatory effects, such as constriction of airways and vascular smooth muscle, increase of…”
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In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition by Hoxha, Malvina, Buccellati, Carola, Capra, Valérie, Garella, Davide, Cena, Clara, Rolando, Barbara, Fruttero, Roberta, Carnevali, Silvia, Sala, Angelo, Rovati, G.Enrico, Bertinaria, Massimo

“…[Display omitted] Patients with high cardiovascular risk due to ageing and/or comorbidity (diabetes, atherosclerosis) that require effective management of…”
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Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation by Capra, Valérie, Busnelli, Marta, Perenna, Alessandro, Ambrosio, Manuela, Accomazzo, Maria Rosa, Galés, Celine, Chini, Bice, Rovati, G Enrico

“…The intrahelical salt bridge between E/D(3.49) and R(3.50) within the E/DRY motif on helix 3 (H3) and the interhelical hydrogen bonding between the E/DRY and…”
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Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk by Rovati, G. Enrico, Sala, Angelo, Capra, Valérie, Dahlén, Sven-Erik, Folco, Giancarlo

“…In the 1990s, after identification of two cyclo-oxygenase (COX) isoforms catalyzing the synthesis of prostaglandins and thromboxane A2 (TXA2 ), a new class of…”
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CysLT₁ receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation by Capra, Valérie, Ravasi, Saula, Accomazzo, Maria Rosa, Citro, Simona, Grimoldi, Monica, Abbracchio, Maria P, Rovati, G. Enrico

“…Both cysteinyl-leukotrienes and extracellular nucleotides mediate inflammatory responses via specific G-protein-coupled receptors, the CysLT and the P2Y…”
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Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants by Ambrosio, Manuela, Fanelli, Francesca, Brocchetti, Silvia, Raimondi, Francesco, Mauri, Mario, Rovati, G. Enrico, Capra, Valérie

“…In class A GPCRs the E/DRY motif is critical for receptor activation and function. According to experimental and computational data, R3.50 forms a double salt…”
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Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors by Bertinaria, Massimo, Shaikh, Mohammed Abrar Abdul Gaffar, Buccellati, Carola, Cena, Clara, Rolando, Barbara, Lazzarato, Loretta, Fruttero, Roberta, Gasco, Alberto, Hoxha, Malvina, Capra, Valérie, Sala, Angelo, Rovati, G. Enrico

“…A series of lumiracoxib derivatives were designed to explore the influence of isosteric substitution on balancing COX‐2 inhibition and thromboxane A2…”
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Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT2 receptor by Capra, Valérie, Carnini, Chiara, Accomazzo, Maria Rosa, Di Gennaro, Antonio, Fiumicelli, Marco, Borroni, Emanuele, Brivio, Ivan, Buccellati, Carola, Mangano, Paolo, Carnevali, Silvia, Rovati, Gianenrico, Sala, Angelo

“…We evaluated the autocrine activities of cysteinyl leukotrienes (cysteinyl-LTs) in HUVEC and studied the signaling and the pharmacological profile of the…”
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A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes by Capra, Valérie, Accomazzo, Maria Rosa, Gardoni, Fabrizio, Barbieri, Silvia, Rovati, G. Enrico

“…Cysteinyl-leukotrienes (cysteinyl-LT) are rapidly generated at sites of inflammation and, in addition to their role in asthma, rhinitis, and other immune…”
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CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors by Mamedova, Liaman, Capra, Valérie, Accomazzo, Maria Rosa, Gao, Zhan-Guo, Ferrario, Silvia, Fumagalli, Marta, Abbracchio, Maria P, Rovati, G Enrico, Jacobson, Kenneth A

“…Montelukast and pranlukast are orally active leukotriene receptor antagonists selective for the CysLT1 receptor. Conversely, the hP2Y(1,2,4,6,11,12,13,14)…”
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The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state by Rovati, G Enrico, Capra, Valérie, Neubig, Richard R

“…Despite extensive study of heptahelical G protein-coupled receptors (GPCRs), the precise mechanism of G protein activation is unknown. The role of one highly…”
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CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras by CAPRA, Valérie, RAVASI, Saula, ACCOMAZZO, Maria Rosa, PARENTI, Marco, ROVATI, G. Enrico

“…We investigated the signal transduction pathway(s) of leukotriene D(4) (LTD(4)) in the human promonocytic U937 cells, a cell line known to constitutively…”
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Leukotrienes and atherosclerosis by Riccioni, Graziano, Bäck, Magnus, Capra, Valérie

“…Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the…”
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