Search Results - "CAPPELLA, Paolo"

Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study by Redaelli, Veronica, Bosi, Alice, Luzi, Fabio, Cappella, Paolo, Zerbi, Pietro, Ludwig, Nicola, Di Lernia, Daniele, Roughan, John Vincent, Porcu, Luca, Soranna, Davide, Parati, Gianfranco, Calvillo, Laura

“…Animal models used to study pathologies requiring rehabilitation therapy, such as cardiovascular and neurologic disorders or oncologic disease, must be as…”
Get full text

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer by Carpinelli, Patrizia, Ceruti, Roberta, Giorgini, Maria Laura, Cappella, Paolo, Gianellini, Laura, Croci, Valter, Degrassi, Anna, Texido, Gemma, Rocchetti, Maurizio, Vianello, Paola, Rusconi, Luisa, Storici, Paola, Zugnoni, Paola, Arrigoni, Claudio, Soncini, Chiara, Alli, Cristina, Patton, Veronica, Marsiglio, Aurelio, Ballinari, Dario, Pesenti, Enrico, Fancelli, Daniele, Moll, Jürgen

“…PHA-739358 is a small-molecule 3-aminopyrazole derivative with strong activity against Aurora kinases and cross-reactivities with some receptor tyrosine…”
Get full text

FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients by Tassi, Renata A, Todeschini, Paola, Siegel, Eric R, Calza, Stefano, Cappella, Paolo, Ardighieri, Laura, Cadei, Moris, Bugatti, Mattia, Romani, Chiara, Bandiera, Elisabetta, Zanotti, Laura, Tassone, Laura, Guarino, Donatella, Santonocito, Concetta, Capoluongo, Ettore D, Beltrame, Luca, Erba, Eugenio, Marchini, Sergio, D'Incalci, Maurizio, Donzelli, Carla, Santin, Alessandro D, Pecorelli, Sergio, Sartori, Enrico, Bignotti, Eliana, Odicino, Franco, Ravaggi, Antonella

“…Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly…”
Get full text

In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation by Scabini, Matteo, Stellari, Fabio, Cappella, Paolo, Rizzitano, Sara, Texido, Gemma, Pesenti, Enrico

“…In vivo imaging of apoptosis in a preclinical setting in anticancer drug development could provide remarkable advantages in terms of translational medicine. So…”
Get full text

novel method based on click chemistry, which overcomes limitations of cell cycle analysis by classical determination of BrdU incorporation, allowing multiplex antibody staining by Cappella, Paolo, Gasparri, Fabio, Pulici, Maurizio, Moll, Jürgen

“…Quantification of BrdU incorporation into DNA is a widely used technique to assess the cell cycle status of cells. DNA denaturation is required for BrdU…”
Get full text

Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

“…Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is…”
Get full text

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity by Soncini, Chiara, Carpinelli, Patrizia, Gianellini, Laura, Fancelli, Daniele, Vianello, Paola, Rusconi, Luisa, Storici, Paola, Zugnoni, Paola, Pesenti, Enrico, Croci, Valter, Ceruti, Roberta, Giorgini, Maria Laura, Cappella, Paolo, Ballinari, Dario, Sola, Francesco, Varasi, Mario, Bravo, Rodrigo, Moll, Jürgen

“…Purpose: Aurora kinases play critical roles during mitosis in chromosome segregation and cell division. The aim of this study was to determine the preclinical…”
Get full text

A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds by Durlak, Marta, Fugazza, Cristina, Elangovan, Sudharshan, Marini, Maria Giuseppina, Marongiu, Maria Franca, Moi, Paolo, Fraietta, Ivan, Cappella, Paolo, Barbarani, Gloria, Font-Monclus, Isaura, Mauri, Mario, Ottolenghi, Sergio, Gasparri, Fabio, Ronchi, Antonella

“…The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin…”
Get full text

Cell Proliferation Method: Click Chemistry Based on BrdU Coupling for Multiplex Antibody Staining by Cappella, Paolo, Gasparri, Fabio, Pulici, Maurizio, Moll, Jürgen

“…Determination of incorporation of the thymidine analog 5-bromo-2'-deoxyuridine (BrdU) into DNA is a widely used method to analyze the cell cycle. However, DNA…”
Get more information

Interpreting cell cycle effects of drugs : the case of melphalan by LUPI, Monica, CAPPELLA, Paolo, MATERA, Giada, NATOLI, Claudia, UBEZIO, Paolo

“…Multiple effects usually occur in the cell cycle, during and after the exposure to a drug, while treated cells flowing through the cycle encounter G1, S and…”
Get full text

Highly multiplexed phenotypic imaging for cell proliferation studies by Cappella, Paolo, Gasparri, Fabio

“…The application of multiplexed imaging technologies in phenotypic drug discovery (PDD) enables profiling of complex cellular perturbations in response to drug…”
Get more information

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase by Colombo, Riccardo, Caldarelli, Marina, Mennecozzi, Milena, Giorgini, Maria Laura, Sola, Francesco, Cappella, Paolo, Perrera, Claudia, Depaolini, Stefania Re, Rusconi, Luisa, Cucchi, Ulisse, Avanzi, Nilla, Bertrand, Jay Aaron, Bossi, Roberto Tiberio, Pesenti, Enrico, Galvani, Arturo, Isacchi, Antonella, Colotta, Francesco, Donati, Daniele, Moll, Jürgen

“…MPS1 kinase is a key regulator of the spindle assembly checkpoint (SAC), a mitotic mechanism specifically required for proper chromosomal alignment and…”
Get full text

NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies by Valsasina, Barbara, Beria, Italo, Alli, Cristina, Alzani, Rachele, Avanzi, Nilla, Ballinari, Dario, Cappella, Paolo, Caruso, Michele, Casolaro, Alessia, Ciavolella, Antonella, Cucchi, Ulisse, De Ponti, Anna, Felder, Eduard, Fiorentini, Francesco, Galvani, Arturo, Gianellini, Laura M, Giorgini, Maria L, Isacchi, Antonella, Lansen, Jaqueline, Pesenti, Enrico, Rizzi, Simona, Rocchetti, Maurizio, Sola, Francesco, Moll, Jürgen

“…Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase considered to be the master player of cell-cycle regulation during mitosis. It is indeed…”
Get full text

Multiparametric cell cycle analysis by automated microscopy by Gasparri, Fabio, Cappella, Paolo, Galvani, Arturo

“…Cell cycle analysis using flow cytometry (FC) to measure cellular DNA content is a common procedure in drug mechanism of action studies. Although this…”
Get more information

1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles:  Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile by Fancelli, Daniele, Moll, Jürgen, Varasi, Mario, Bravo, Rodrigo, Artico, Roberta, Berta, Daniela, Bindi, Simona, Cameron, Alexander, Candiani, Ilaria, Cappella, Paolo, Carpinelli, Patrizia, Croci, Walter, Forte, Barbara, Giorgini, Maria Laura, Klapwijk, Jan, Marsiglio, Aurelio, Pesenti, Enrico, Rocchetti, Maurizio, Roletto, Fulvia, Severino, Dino, Soncini, Chiara, Storici, Paola, Tonani, Roberto, Zugnoni, Paola, Vianello, Paola

“…The optimization of a series of 5-phenylacetyl 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives toward the inhibition of Aurora kinases led to the…”
Get full text

From “Click” to “Fenton” chemistry for 5‐bromo‐2′‐deoxyuridine determination by Cappella, Paolo, Giansanti, Vincenzo, Pulici, Maurizio, Gasparri, Fabio

“…Ascorbic acid (AA) and copper have been increasingly employed in flow cytometry (FCM) and high content analysis (HCA) since the introduction of “click…”
Get full text

CyTOF Mass Cytometry for Click Proliferation Assays by Tosevski, Vinko, Ulashchik, Egor, Trovato, Andrea, Cappella, Paolo

“…Novel cell analyzers, including polychromatic flow cytometers and isotopical cytometry by time of flight (CyTOF) mass cytometers, enable simultaneous…”
Get more information

Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

Get full text

Application of click chemistry conditions for 5-bromo-2'-deoxyuridine determination through Fenton and related reactions by Cappella, Paolo, Pulici, Maurizio, Gasparri, Fabio

“…Mixtures of ascorbate and copper used in certain click chemistry experimental conditions act as oxidizing agents, catalyzing the formation of reactive oxygen…”
Get more information

Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study by Veronica Redaelli, Alice Bosi, Fabio Luzi, Paolo Cappella, Pietro Zerbi, Nicola Ludwig, Daniele Di Lernia, John Vincent Roughan, Luca Porcu, Davide Soranna, Gianfranco Parati, Laura Calvillo

“…BackgroundAnimal models used to study pathologies requiring rehabilitation therapy, such as cardiovascular and neurologic disorders or oncologic disease, must…”
Get full text