Search Results - "CAPPARELLI, Edmund"

Population pharmacokinetics of siltuximab: impact of disease state by Nikanjam, Mina, Yang, Jin, Capparelli, Edmund V.

“…Purpose To characterize the effects of disease type and clinical characteristics on the pharmacokinetics of siltuximab, an IL-6 inhibiting monoclonal antibody…”
Get full text

Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent by Capparelli, Edmund V, Bricker-Ford, Robin, Rogers, M John, McKerrow, James H, Reed, Sharon L

“…Under an NIH priority to identify new drugs to treat class B parasitic agents, we performed high-throughput screens, which identified the activity of auranofin…”
Get full text

Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir by Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella, den Anker, John N., Green, Dionna J., Burckart, Gilbert J., Best, Brookie M., Mirochnick, Mark, Capparelli, Edmund V., Dallmann, André

“…Pregnancy is associated with physiological changes that may impact drug pharmacokinetics (PK). The goals of this study were to build maternal‐fetal…”
Get full text

Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life by Maswabi, Kenneth, Ajibola, Gbolahan, Bennett, Kara, Capparelli, Edmund V, Jean-Philippe, Patrick, Moyo, Sikhulile, Mohammed, Terence, Batlang, Oganne, Sakoi, Maureen, Lockman, Shahin, Makhema, Joseph, Lichterfeld, Mathias, Kuritzkes, Daniel R, Hughes, Michael D, Shapiro, Roger L

“…Abstract Background Early antiretroviral therapy (ART) is recommended for infants with human immunodeficiency virus (HIV) infection. However, few…”
Get full text

Anakinra Treatment in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysms: A Phase I/IIa Trial by Yang, Jincheng, Jain, Sonia, Capparelli, Edmund V., Best, Brookie M., Son, Mary Beth, Baker, Annette, Newburger, Jane W., Franco, Alessandra, Printz, Beth F., He, Feng, Shimizu, Chisato, Hoshino, Shinsuke, Bainto, Emelia, Moreno, Elizabeth, Pancheri, Joan, Burns, Jane C., Tremoulet, Adriana H.

“…To determine the safety, pharmacokinetics, and immunomodulatory effects of 2-6 weeks of anakinra therapy in patients with acute Kawasaki disease with a…”
Get full text

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants by Jacqz-Aigrain, Evelyne, Leroux, Stéphanie, Thomson, Alison H, Allegaert, Karel, Capparelli, Edmund V, Biran, Valérie, Simon, Nicolas, Meibohm, Bernd, Lo, Yoke-Lin, Marques, Remedios, Peris, José-Esteban, Lutsar, Irja, Saito, Jumpei, Nakamura, Hidefumi, van den Anker, Johannes N, Sharland, Mike, Zhao, Wei

“…In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. A 'meta-model' with…”
Get full text

Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients by Kawakatsu, Sonoko, Nikanjam, Mina, Lin, Mark, Le, Sonny, Saunders, Ila, Kuo, Dennis John, Capparelli, Edmund V.

“…Purpose High-dose methotrexate (HD-MTX) is widely used in pediatric and adult oncology treatment regimens. This study aimed to develop a population…”
Get full text

Intraperitoneal vancomycin for peritoneal dialysis-associated peritonitis in children: Evaluation of loading dose guidelines by Hennessy, Kathleen, Capparelli, Edmund V, Romanowski, Gale, Alejandro, Lawrence, Murray, William, Benador, Nadine

“…Background: Current pediatric International Society for Peritoneal Dialysis guidelines for initial treatment of peritoneal dialysis (PD)-associated peritonitis…”
Get full text

Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV by Mulligan, Nikki, Best, Brookie M, Wang, Jiajia, Capparelli, Edmund V, Stek, Alice, Barr, Emily, Buschur, Shelley L, Acosta, Edward P, Smith, Elizabeth, Chakhtoura, Nahida, Burchett, Sandra, Mirochnick, Mark

“…OBJECTIVE:To evaluate dolutegravir pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery. DESIGN:Ongoing,…”
Get full text

Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure by Béranger, Agathe, Bekker, Adrie, Solans, Belén P, Cotton, Mark F, Mirochnick, Mark, Violari, Avy, Wang, Jiajia, Cababasay, Mae, Wiesner, Lubbe, Browning, Renee, Moye, Jack, Capparelli, Edmund V, Savic, Radojka M

“…Abstract Background Isoniazid (INH) metabolism depends on the N-acetyl transferase 2 (NAT2) enzyme, whose maturation process remains unknown in low birth…”
Get full text

Optimizing Pharmacology Studies in Pregnant and Lactating Women Using Lessons From HIV: A Consensus Statement by Eke, Ahizechukwu C., Olagunju, Adeniyi, Momper, Jeremiah, Penazzato, Martina, Abrams, Elaine J., Best, Brookie M., Capparelli, Edmund V., Bekker, Adrie, Belew, Yodit, Kiser, Jennifer J., Struble, Kimberly, Taylor, Graham, Waitt, Catriona, Mirochnick, Mark, Cressey, Tim R., Colbers, Angela, Abrams, Elaine, Aldrovandi, Grace, Bekker, Adrie, Belew, Yodit, Best, Brookie, Black, Roberta, Boffito, Marta, Bremer, Andrew, Brooks, Kristina, Burger, David, Capparelli, Edmund, Chakhtoura, Nahida, Chinula, Lamek, Chokephaibulkit, Kulkanya, Clarke, Diana, Colbers, Angela, Court, Richard, Cressey, Tim R, Eke, Ahizechukwu, El Gaaloul, Myriam, Fenton, Terrence, Hazra, Rohan, Jean‐Philippe, Patrick, Kinuthia, John, Kiser, Jennifer, Kreitchman, Regis, Lamorde, Mohammed, Lewis, Linda, Little, Maggie

“…Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of…”
Get full text

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy by Glauser, Tracy A, Cnaan, Avital, Shinnar, Shlomo, Hirtz, Deborah G, Dlugos, Dennis, Masur, David, Clark, Peggy O, Capparelli, Edmund V, Adamson, Peter C

“…In this randomized trial of three common treatments for childhood absence epilepsy, ethosuximide and valproic acid were more effective than lamotrigine, and…”
Get full text

Improved vancomycin dosing in children using area under the curve exposure by Le, Jennifer, Bradley, John S, Murray, William, Romanowski, Gale L, Tran, Tu T, Nguyen, Natalie, Cho, Susan, Natale, Stephanie, Bui, Ivilynn, Tran, Tri M, Capparelli, Edmund V

“…: Our objectives were to (1) determine the pharmacokinetic indices of vancomycin in pediatric patients; and (2) compare attainment of 2 target exposures: area…”
Get full text

Maraviroc Population Pharmacokinetics Within the First 6 Weeks of Life by Liyanage, Marlon, Nikanjam, Mina, McFadyen, Lynn, Vourvahis, Manoli, Rogg, Luise, Moye, John, Chadwick, Ellen G., Jean-Philippe, Patrick, Mirochnick, Mark, Whitson, Kyle, Bradford, Sarah, Capparelli, Edmund V., Best, Brookie M.

“…Treatment and prophylaxis options for neonatal HIV are limited. This study aimed to develop a population pharmacokinetic model to characterize the disposition…”
Get full text

Safety, Tolerability, and Pharmacokinetics of a Long-Acting Broadly Neutralizing Human Immunodeficiency Virus Type 1 (HIV-1) Monoclonal Antibody VRC01LS in HIV-1–Exposed Newborn Infants by McFarland, Elizabeth J, Cunningham, Coleen K, Muresan, Petronella, Capparelli, Edmund V, Perlowski, Charlotte, Morgan, Patricia, Smith, Betsy, Hazra, Rohan, Purdue, Lynette, Harding, Paul A, Theron, Gerhard, Mujuru, Hilda, Agwu, Allison, Purswani, Murli, Rathore, Mobeen H, Flach, Britta, Taylor, Alison, Lin, Bob C, McDermott, Adrian B, Mascola, John R, Graham, Barney S

“…Abstract Background Perinatal human immunodeficiency virus type 1 (HIV-1) continues to occur due to barriers to effective antiretroviral prevention that might…”
Get full text

Population Pharmacokinetics of Tenofovir in Pregnant and Postpartum Women Using Tenofovir Disoproxil Fumarate by Eke, Ahizechukwu C, Shoji, Kensuke, Best, Brookie M, Momper, Jeremiah D, Stek, Alice M, Cressey, Tim R, Mirochnick, Mark, Capparelli, Edmund V

“…Pharmacokinetics of drugs can be affected by physiologic changes during pregnancy. Our aim was to assess the influence of covariates on tenofovir (TFV)…”
Get full text

Optimizing Dolutegravir Initiation in Neonates Using Population Pharmacokinetic Modeling and Simulation by Piscitelli, Joseph, Nikanjam, Mina, Best, Brookie M., Acosta, Edward, Mirochnick, Mark, Clarke, Diana F., Capparelli, Edmund V., Momper, Jeremiah D.

“…A knowledge gap exists for dolutegravir (DTG) pharmacokinetics and safety during the first 4 weeks of life, preventing safe and effective DTG use in neonates…”
Get full text

Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection by Funderburg, Nicholas T, Shive, Carey L, Chen, Zhengyi, Tatsuoka, Curtis, Bowman, Emily R, Longenecker, Chris T, McComsey, Grace A, Clagett, Brian M, Dorazio, Dominic, Freeman, Michael L, Sieg, Scott F, Moisi, Daniela, Anthony, Donald D, Jacobson, Jeffrey M, Stein, Sharon L, Calabrese, Leonard H, Landay, Alan, Flexner, Charles, Crawford, Keith W, Capparelli, Edmund V, Rodriguez, Benigno, Lederman, Michael M

“…Abstract Background People with human immunodeficiency virus (PWH) are at increased risk for comorbidities, and plasma interleukin 6 (IL-6) levels are among…”
Get full text

Pharmacokinetics of darunavir and cobicistat in pregnant and postpartum women with HIV by Momper, Jeremiah D., Wang, Jiajia, Stek, Alice, Shapiro, David E., Scott, Gwendolyn B., Paul, Mary E., Febo, Irma L., Burchett, Sandra, Smith, Elizabeth, Chakhtoura, Nahida, Denson, Kayla, Rungruengthanakit, Kittipong, George, Kathleen, Yang, Derek Z., Capparelli, Edmund V., Mirochnick, Mark, Best, Brookie M.

“…To evaluate darunavir and cobicistat pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery. Nonrandomized,…”
Get full text

Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies by Silmore, Lucy H., Willmer, Andrew R., Capparelli, Edmund V., Rosania, Gus R.

“…Cannabidiol (CBD), a non‐psychotropic phytocannabinoid from the Cannabis plant, is increasingly being pursued as a treatment for differing ailments. The…”
Get full text