Search Results - "CAPOWSKI, E. E"

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines by Capowski, Elizabeth E, Samimi, Kayvan, Mayerl, Steven J, Phillips, M Joseph, Pinilla, Isabel, Howden, Sara E, Saha, Jishnu, Jansen, Alex D, Edwards, Kimberly L, Jager, Lindsey D, Barlow, Katherine, Valiauga, Rasa, Erlichman, Zachary, Hagstrom, Anna, Sinha, Divya, Sluch, Valentin M, Chamling, Xitiz, Zack, Donald J, Skala, Melissa C, Gamm, David M

“…Numerous protocols have been described for producing neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D…”
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Modeling early retinal development with human embryonic and induced pluripotent stem cells by Meyer, Jason S, Shearer, Rebecca L, Capowski, Elizabeth E, Wright, Lynda S, Wallace, Kyle A, McMillan, Erin L, Zhang, Su-Chun, Gamm, David M

“…Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity,…”
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Optic Vesicle‐like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment by Meyer, Jason S., Howden, Sara E., Wallace, Kyle A., Verhoeven, Amelia D., Wright, Lynda S., Capowski, Elizabeth E., Pinilla, Isabel, Martin, Jessica M., Tian, Shulan, Stewart, Ron, Pattnaik, Bikash, Thomson, James A., Gamm, David M.

“…Differentiation methods for human induced pluripotent stem cells (hiPSCs) typically yield progeny from multiple tissue lineages, limiting their use for drug…”
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Generation of a rod-specific NRL reporter line in human pluripotent stem cells by Phillips, M. Joseph, Capowski, Elizabeth E., Petersen, Andrew, Jansen, Alex D., Barlow, Katherine, Edwards, Kimberly L., Gamm, David M.

“…Reporter lines generated in human pluripotent stem cells can be highly useful for the analysis of specific cell types and lineages in live cultures. We created…”
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A Novel Approach to Single Cell RNA‐Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell‐Derived Retinal Cell Types by Phillips, M. Joseph, Jiang, Peng, Howden, Sara, Barney, Patrick, Min, Jee, York, Nathaniel W., Chu, Li‐Fang, Capowski, Elizabeth E., Cash, Abigail, Jain, Shivani, Barlow, Katherine, Tabassum, Tasnia, Stewart, Ron, Pattnaik, Bikash R., Thomson, James A., Gamm, David M.

“…Cell type‐specific investigations commonly use gene reporters or single‐cell analytical techniques. However, reporter line development is arduous and generally…”
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A combined RNA-seq and whole genome sequencing approach for identification of non-coding pathogenic variants in single families by Bronstein, Revital, Capowski, Elizabeth E, Mehrotra, Sudeep, Jansen, Alex D, Navarro-Gomez, Daniel, Maher, Mathew, Place, Emily, Sangermano, Riccardo, Bujakowska, Kinga M, Gamm, David M, Pierce, Eric A

“…Abstract Inherited retinal degenerations (IRDs) are at the focus of current genetic therapeutic advancements. For a genetic treatment such as gene therapy to…”
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Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells by Capowski, Elizabeth E., Wright, Lynda S., Liang, Kun, Phillips, M. Joseph, Wallace, Kyle, Petelinsek, Anna, Hagstrom, Anna, Pinilla, Isabel, Borys, Katarzyna, Lien, Jessica, Min, Jee Hong, Keles, Sunduz, Thomson, James A., Gamm, David M.

“…Few gene targets of Visual System Homeobox 2 (VSX2) have been identified despite its broad and critical role in the maintenance of neural retina (NR) fate…”
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Investigating cone photoreceptor development using patient-derived NRL null retinal organoids by Kallman, Alyssa, Capowski, Elizabeth E., Wang, Jie, Kaushik, Aniruddha M., Jansen, Alex D., Edwards, Kimberly L., Chen, Liben, Berlinicke, Cynthia A., Joseph Phillips, M., Pierce, Eric A., Qian, Jiang, Wang, Tza-Huei, Gamm, David M., Zack, Donald J.

“…Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would…”
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Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates by BEHRSTOCK, S, EBERT, A, SVENDSEN, C. N, MCHUGH, J, VOSBERG, S, MOORE, J, SCHNEIDER, B, CAPOWSKI, E, HEI, D, KORDOWER, J, AEBISCHER, P

“…Glial cell line-derived neurotrophic factor (GDNF) has been shown to increase the survival and functioning of dopamine neurons in a variety of animal models…”
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VSX2 and ASCL1 Are Indicators of Neurogenic Competence in Human Retinal Progenitor Cultures by Wright, Lynda S, Pinilla, Isabel, Saha, Jishnu, Clermont, Joshua M, Lien, Jessica S, Borys, Katarzyna D, Capowski, Elizabeth E, Phillips, M Joseph, Gamm, David M

“…Three dimensional (3D) culture techniques are frequently used for CNS tissue modeling and organoid production, including generation of retina-like tissues. A…”
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Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation by Schneider, Bernard L., Seehus, Corey R., Capowski, Elizabeth E., Aebischer, Patrick, Zhang, Su-Chun, Svendsen, Clive N.

“…Missense mutations and extra copies of the α-Synuclein gene result in Parkinson disease (PD). Human stem and progenitor cells can be expanded from embryonic…”
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Y Box-Binding Factor Promotes Eosinophil Survival by Stabilizing Granulocyte-Macrophage Colony-Stimulating Factor mRNA by Capowski, Elizabeth E, Esnault, Stephane, Bhattacharya, Saswati, Malter, James S

“…Short-lived peripheral blood eosinophils are recruited to the lungs of asthmatics after allergen challenge, where they become long-lived effector cells central…”
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Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy by Capowski, Elizabeth E., Schneider, Bernard L., Ebert, Allison D., Seehus, Corey R., Szulc, Jolanta, Zufferey, Romain, Aebischer, Patrick, Svendsen, Clive N.

“…Human neural progenitor cells (hNPC) hold great potential as an ex vivo system for delivery of therapeutic proteins to the central nervous system. When…”
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The Role of FGF9 in the Production of Neural Retina and RPE in a Pluripotent Stem Cell Model of Early Human Retinal Development by Gamm, David M., Clark, Eric, Capowski, Elizabeth E., Singh, Ruchira

“…To investigate the role of fibroblast growth factors (FGFs) in the production of neural retina (NR) and retinal pigmented epithelium (RPE) in a human…”
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Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1 by Gamm, David M., Wright, Lynda S., Capowski, Elizabeth E., Shearer, Rebecca L., Meyer, Jason S., Kim, Hyun‐Jung, Schneider, Bernard L., Melvan, John Nicholas, Svendsen, Clive N.

“…During development of the central nervous system, stem and progenitor cell proliferation and differentiation are controlled by complex inter‐ and intracellular…”
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Identification of Grandchildless Loci Whose Products Are Required for Normal Germ-Line Development in the Nematode Caenorhabditis elegans by Capowski, E. E, Martin, P, Garvin, C, Strome, S

“…To identify genes that encode maternal components required for development of the germ line in the nematode Caenorhabditis elegans, we have screened for…”
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DPY-26, a Link between Dosage Compensation and Meiotic Chromosome Segregation in the Nematode by Lieb, Jason D., Capowski, Elizabeth E., Meneely, Philip, Meyer, Barbara J.

“…The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome…”
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iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration by Singh, Ruchira, Shen, Wei, Kuai, David, Martin, Jessica M, Guo, Xiangrong, Smith, Molly A, Perez, Enio T, Phillips, M Joseph, Simonett, Joseph M, Wallace, Kyle A, Verhoeven, Amelia D, Capowski, Elizabeth E, Zhang, Xiaoqing, Yin, Yingnan, Halbach, Patrick J, Fishman, Gerald A, Wright, Lynda S, Pattnaik, Bikash R, Gamm, David M

“…Best disease (BD) is an inherited degenerative disease of the human macula that results in progressive and irreversible central vision loss. It is caused by…”
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Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses by Phillips, M Joseph, Wallace, Kyle A, Dickerson, Sarah J, Miller, Michael J, Verhoeven, Amelia D, Martin, Jessica M, Wright, Lynda S, Shen, Wei, Capowski, Elizabeth E, Percin, E Ferda, Perez, Enio T, Zhong, Xiufeng, Canto-Soler, Maria V, Gamm, David M

“…We sought to determine if human induced pluripotent stem cells (iPSCs) derived from blood could produce optic vesicle-like structures (OVs) with the capacity…”
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Functional analysis of serially expanded human iPS cell-derived RPE cultures by Singh, Ruchira, Phillips, M Joseph, Kuai, David, Meyer, Jackelyn, Martin, Jessica M, Smith, Molly A, Perez, Enio T, Shen, Wei, Wallace, Kyle A, Capowski, Elizabeth E, Wright, Lynda S, Gamm, David M

“…To determine the effects of serial expansion on the cellular, molecular, and functional properties of human iPS cell (hiPSC)-derived RPE cultures. Fibroblasts…”
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