Search Results - "CAPETTINI, Luciano"

Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation by Silva, Irismara Sousa, Almeida, Aline D., Lima Filho, Antônio C. M., Fernandes-Braga, Weslley, Barra, Ayslan, Oliveira, Hortência M. C., Cassali, Geovanni D., Capettini, Luciano S. A., Menezes, Gustavo B., Alvarez-Leite, Jacqueline I., Leite, Maria F., Klein, André

“…Although it is well established that platelet-activated receptor (PAF) and protease-activated receptor 2 (PAR2) play a pivotal role in the pathophysiology of…”
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Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress by Dardi, Patrizia, Perazza, Laís Rossi, Couto, Gisele Kruger, Campos, Gianne Paul, Capettini, Luciano Dos Santos Aggum, Rossoni, Luciana Venturini

“…Arterial endothelial dysfunction has been extensively studied in heart failure (HF). However, little is known about the adjustments shown by the venous system…”
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Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells by Aguilar, Edenil C., Santos, Lana Claudinez dos, Leonel, Alda J., de Oliveira, Jamil Silvano, Santos, Elândia Aparecida, Navia-Pelaez, Juliana M., da Silva, Josiane Fernandes, Mendes, Bárbara Pinheiro, Capettini, Luciano S.A., Teixeira, Lilian G., Lemos, Virginia S., Alvarez-Leite, Jacqueline I.

“…Butyrate is a 4-carbon fatty acid that has antiinflammatory and antioxidative properties. It has been demonstrated that butyrate is able to reduce…”
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Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine by Campos-Mota, Gianne P, Navia-Pelaez, Juliana M, Araujo de Souza, Jessica Cristina, Stergiopulos, Nikos, Capettini, Luciano S.A

“…Abstract Background and aims Lysophosphatidylcholine (LPC) – a main component of oxidized LDL - is involved in endothelial dysfunction that precedes…”
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Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta by Capettini, Luciano S.A., Cortes, Steyner F., Lemos, Virginia S.

“…In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial nitric oxide synthase (eNOS)-derived NO production. However, we have…”
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Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain by Navia-Pelaez, Juliana M, Choi, Soo-Ho, Dos Santos Aggum Capettini, Luciano, Xia, Yining, Gonen, Ayelet, Agatisa-Boyle, Colin, Delay, Lauriane, Gonçalves Dos Santos, Gilson, Catroli, Glaucilene F, Kim, Jungsu, Lu, Jenny W, Saylor, Benjamin, Winkels, Holger, Durant, Christopher P, Ghosheh, Yanal, Beaton, Graham, Ley, Klaus, Kufareva, Irina, Corr, Maripat, Yaksh, Tony L, Miller, Yury I

“…Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation of TLR4,…”
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Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques by Fraga-Silva, Rodrigo A, Savergnini, Silvia Q, Montecucco, Fabrizio, Nencioni, Alessio, Caffa, Irene, Soncini, Debora, Costa-Fraga, Fabiana P, De Sousa, Frederico B, Sinisterra, Ruben D, Capettini, Luciano A S, Lenglet, Sébastien, Galan, Katia, Pelli, Graziano, Bertolotto, Maria, Pende, Aldo, Spinella, Giovanni, Pane, Bianca, Dallegri, Franco, Palombo, Domenico, Mach, François, Stergiopulos, Nikolaos, Santos, Robson A S, da Silva, Rafaela F

“…Angiotensin (Ang)-(1-7), acting through the receptor Mas, has atheroprotective effects; however, its role on plaque vulnerability has been poorly studied…”
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The atheroprotective role of fucoidan involves the reduction of foam cell formation by altering cholesterol flux-associated factors in macrophages by Fernandes-Braga, Weslley, Aguilar, Edenil Costa, Navia-Pelaez, Juliana Maria, Ávila, Danielle Lima, Rezende, Luisa, Andrade, Luciana de Oliveira, Miranda, Sued Eustáquio Mendes, Barros, Andre Luis Branco de, Capettini, Luciano dos Santos Aggum, Alvarez-Leite, Jacqueline Isaura

“…Atherosclerosis is characterized by the accumulation of lipid-laden cells in the arterial walls, resulting from dysregulation of cholesterol homeostasis in the…”
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Resistance exercise mediates remote ischemic preconditioning by limiting cardiac eNOS uncoupling by Santana, Michael Nadson Santos, Souza, Diego Santos, Miguel-dos-Santos, Rodrigo, Rabelo, Thallita Kelly, Vasconcelos, Carla Maria Lins de, Navia-Pelaez, Juliana Maria, Jesus, Itamar Couto Guedes de, Silva-Neto, Julio Alves da, Lauton-Santos, Sandra, Capettini, Luciano dos Santos Aggum, Guatimosim, Silvia, Rogers, Russell G., Santos, Márcio Roberto Viana dos, Santana-Filho, Valter Joviniano, Mesquita, Thássio Ricardo Ribeiro

“…Currently viewed as a complementary non-pharmacological intervention for preventing cardiac disorders, long-term aerobic training produces cardioprotection…”
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Protease-activated receptor 2 enhances innate and inflammatory mechanisms induced by lipopolysaccharide in macrophages from C57BL/6 mice by Barra, Ayslan, Brasil, Amanda Ferreira, Ferreira, Thaís Lemos, Fernandes-Braga, Weslley, Marconato, Danielle Gomes, Faria-Pinto, Priscila, Alvarez-Leite, Jacqueline Isaura, dos Santos Aggum Capettini, Luciano, Klein, André

“…Objective This study was conducted to investigate the effects of the synthetic PAR2 agonist peptide (PAR2-AP) SLIGRL-NH 2 on LPS-induced inflammatory…”
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Role of renin-angiotensin system in inflammation, immunity and aging by Capettini, Luciano S A, Montecucco, Fabrizio, Mach, Francois, Stergiopulos, Nikos, Santos, Robson A S, da Silva, Rafaela F

“…Recent data support the idea that the effects of RAS are not restricted to the cardiovascular and renal systems. Importantly, RAS modulates free radical…”
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Mechanisms of vascular dysfunction in acute phase of Trypanosoma cruzi infection in mice by Silva, Josiane F, Capettini, Luciano S.A, da Silva, José F.P, Sales-Junior, Policarpo, Cruz, Jader Santos, Cortes, Steyner F, Lemos, Virginia S

“…Abstract Vascular disorders have a direct link to mortality in the acute phase of Trypanosoma cruzi infection. However, the underlying mechanisms of vascular…”
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Contribution of RAS, ROS and COX-1-derived prostanoids to the contractile profile of perivascular adipose tissue in cafeteria diet-induced obesity by dos Reis Costa, Daniela Esteves Ferreira, de Araújo, Natália Ferreira, Nóbrega, Natália Ribeiro Cabacinha, de Assis Rabelo Ribeiro, Naiara, de Oliveira, Amanda Carla Clemente, dos Santos Aggum Capettini, Luciano, Ferreira, Adaliene Versiani Matos, Bonaventura, Daniella

“…AIMSObesity can lead to the loss of the anticontractile properties of perivascular adipose tissue (PVAT). Given that cafeteria (CAF) diet reflects the variety…”
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Paraquat poisoning induces TNF-α-dependent iNOS/NO mediated hyporesponsiveness of the aorta to vasoconstrictors in rats by Aires, Rosária D, Capettini, Luciano S A, Silva, Josiane F, Rodrigues-Machado, Maria da Glória, Pinho, Vanessa, Teixeira, Mauro M, Cortes, Steyner F, Lemos, Virginia S

“…Paraquat is a toxic herbicide that may induce acute lung injury, circulatory failure and death. The present work aimed at investigating whether there is…”
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Gluten worsens non-alcoholic fatty liver disease by affecting lipogenesis and fatty acid oxidation in diet-induced obese apolipoprotein E-deficient mice by Aguilar, Edenil Costa, Fernandes-Braga, Weslley, Santos, Elandia Aparecida, Leocádio, Paola Caroline Lacerda, dos Santos Aggum Capettini, Luciano, Orellano, Laura Alejandra Ariza, Campos, Paula Peixoto, Lemos, Virginia Soares, Soares, Fabíola Lacerda Pires, Navia-Pelaez, Juliana Maria, Alvarez-Leite, Jacqueline I.

“…Obesity is closely associated with non-alcoholic fatty liver disease (NAFLD), characterized by hepatic fat accumulation and hepatocyte injury. Preclinical…”
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Sodium butyrate modulates adipocyte expansion, adipogenesis, and insulin receptor signaling by upregulation of PPAR-γ in obese Apo E knockout mice by Aguilar, Edenil Costa, da Silva, Josiane Fernandes, Navia-Pelaez, Juliana Maria, Leonel, Alda Jusceline, Lopes, Lorrayne Gonçalves, Menezes-Garcia, Zélia, Ferreira, Adaliene Versiani Matos, Capettini, Luciano dos Santos Aggum, Teixeira, Lilian G., Lemos, Virginia Soares, Alvarez-Leite, Jacqueline I.

“…Studies suggest that sodium butyrate reduces obesity-associated inflammation and insulin resistance in in vitro and in vivo models. Apo E−/− mice have high…”
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Wheat gluten intake increases the severity of experimental colitis and bacterial translocation by weakening of the proteins of the junctional complex by Menta, Penélope L. R., Andrade, Maria E. R., Leocádio, Paola C. L., Fraga, Júlia R., Dias, Melissa T. S., Cara, Denise C., Cardoso, Valbert N., Borges, Luciano F., Capettini, Luciano S. A., Aguilar, Edenil C., Alvarez-Leite, Jacqueline I.

“…Gluten is only partially digested by intestinal enzymes and can generate peptides that can alter intestinal permeability, facilitating bacterial translocation,…”
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Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein) by Low, Hann, Mukhamedova, Nigora, Capettini, Luciano dos Santos Aggum, Xia, Yining, Carmichael, Irena, Cody, Stephen H, Huynh, Kevin, Ditiatkovski, Michael, Ohkawa, Ryunosuke, Bukrinsky, Michael, Meikle, Peter J, Choi, Soo-Ho, Field, Seth, Miller, Yury I, Sviridov, Dmitri

“…OBJECTIVE:AIBP (apolipoprotein A-I binding protein) is an effective and selective regulator of lipid rafts modulating many metabolic pathways originating from…”
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Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice by Scheuermann, Karina, Orellano, Laura Alejandra Ariza, Viana, Celso Tarso Rodrigues, Machado, Clara Tolentino, Lazari, Marcela Guimarães Takahashi, Capettini, Luciano Santos Aggum, Andrade, Silvia Passos, Campos, Paula Peixoto

“…Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects…”
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Age-related changes in vascular responses to angiotensin-(1-7) in female mice by Costa-Fraga, Fabiana P, Goncalves, Gleisy K, Souza-Neto, Fernando P, Reis, Adelina M, Capettini, Luciano AS, Santos, Robson AS, Fraga-Silva, Rodrigo A, Stergiopulos, Nikolaos, da Silva, Rafaela F

“…The vasodilatory effect of angiotensin-(1-7) seems to vary between sexes, and estradiol (E2) can modulate the magnitude of the Ang-(1-7) vasodilatory response…”
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