Search Results - "CAPALDI, R. A"

Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis by Hagiwara, M., Yamagata, K., Capaldi, R.A., Koyama, A.

“…Focal segmental glomerular sclerosis (FSGS) is a major renal complication of mitochondrial (mt) cytopathies. The present study was designed to investigate the…”
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Structure and Function of Cytochrome c Oxidase by Capaldi, R A

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A Missense Mutation of Cytochrome Oxidase Subunit II Causes Defective Assembly and Myopathy by Rahman, Shamima, Taanman, Jan-Willem, Cooper, J. Mark, Nelson, Isabelle, Hargreaves, Ian, Meunier, Brigitte, Hanna, Michael G, García, José J., Capaldi, Roderick A., Lake, Brian D., Leonard, James V., Schapira, Anthony H.V.

“…We report the first missense mutation in the mtDNA gene for subunit II of cytochrome c oxidase (COX). The mutation was identified in a 14-year-old boy with a…”
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The changing face of mitochondrial research by Capaldi, R A

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The T9176G mutation of human mtDNA gives a fully assembled but inactive ATP synthase when modeled in Escherichia coli by Carrozzo, R., Murray, J., Santorelli, F.M., Capaldi, R.A.

“…A new mutation in human F 1F 0 ATPase6, T9176G, which changes Leu 217 to an Arg, has been described in two siblings with Leigh syndrome [Carrozzo et al. (2000)…”
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Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme by TAANMAN, J.-W, CAPALDI, R. A

“…Yeast cytochrome c oxidase has been isolated by ion exchange chromatography using lauryl maltoside (n-dodecyl beta-D-maltoside) as the solubilizing detergent…”
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Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry by Murray, James, Taylor, Steven W, Zhang, Bing, Ghosh, Soumitra S, Capaldi, Roderick A

“…There is growing evidence that oxidative phosphorylation (OXPHOS) generates reactive oxygen and nitrogen species within mitochondria as unwanted byproducts…”
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Characterization of the human heart mitochondrial proteome by Glenn, Gary M, Taylor, Steven W, Gibson, Bradford W, Murphy, Anne N, Capaldi, Roderick A, Fahy, Eoin, Ghosh, Soumitra S, Warnock, Dale E, Zhang, Bing, Wiley, Sandra, Gaucher, Sara P

“…To gain a better understanding of the critical role of mitochondria in cell function, we have compiled an extensive catalogue of the mitochondrial proteome…”
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ATP hydrolysis-driven structural changes in the gamma-subunit of Escherichia coli ATPase monitored by fluorescence from probes bound at introduced cysteine residues by TURINA, P, CAPALDI, R. A

“…Four mutants of the Escherichia coli F1ATPase, gamma S8-C, gamma T106-C, gamma S179-C, and gamma V286-C, which have a cysteine introduced at different sites in…”
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Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration by Nadanaciva, Sashi, Dykens, James A., Bernal, Autumn, Capaldi, Roderick A., Will, Yvonne

“…Mitochondrial impairment is increasingly implicated in the etiology of toxicity caused by some thiazolidinediones, fibrates, and statins. We examined the…”
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Structure and assembly of cytochrome c oxidase by Capaldi, R A

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Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays by Willis, J.H., Capaldi, R.A., Huigsloot, M., Rodenburg, R.J.T., Smeitink, J., Marusich, M.F.

“…OXPHOS deficits are associated with most reported cases of inherited, degenerative and acquired mitochondrial disease. Traditional methods of measuring OXPHOS…”
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Subunit VIa of yeast cytochrome c oxidase is not necessary for assembly of the enzyme complex but modulates the enzyme activity. Isolation and characterization of the nuclear-coded gene by Taanman, J.W., Capaldi, R.A.

“…COX13, the nuclear gene for cytochrome c oxidase subunit VIa of Saccharomyces cerevisiae, has been isolated in two steps. First, the partial amino acid…”
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Ligand-dependent structural variations in Escherichia coli F1 ATPase revealed by cryoelectron microscopy by GOGOL, E. P, JOHNSTON, E, AGGELER, R, CAPALDI, R. A

“…The Escherichia coli F1 ATPase, ECF1, has been examined by cryoelectron microscopy after reaction with Fab' fragments generated from monoclonal antibodies to…”
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Analysis of Steady-state Protein Phosphorylation in Mitochondria Using a Novel Fluorescent Phosphosensor Dye by Schulenberg, Birte, Aggeler, Robert, Beechem, Joseph M., Capaldi, Roderick A., Patton, Wayne F.

“…The phosphorylation of mitochondrial proteins is pivotal to the regulation of respiratory activity in the cell and to signaling pathways leading to apoptosis,…”
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Cross-linking of the gamma subunit of the Escherichia coli ATPase (ECF1) via cysteines introduced by site-directed mutagenesis by Aggeler, R, Capaldi, R.A.

“…The gamma subunit of the Escherichia coli F1 ATPase (ECF1) has been altered by site-directed mutagenesis to create five different mutants, gamma-S8C,…”
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Introduction of reactive cysteine residues in the ε subunit of Escherichia coli F1 ATPase, modification of these sites with tetrafluorophenyl azide-maleimides, and examination of changes in the binding of the ε subunit when different nucleotides are in catalytic sites by AGGELER, R, CHICAS-CRUZ, K, SUI-XIONG CAI, KEANA, J. F. W, CAPALDI, R. A

“…Cysteine residues have been exchanged for serine residues at positions 10 and 108 in the epsilon subunit of the Escherichia coli F1 ATPase by site-directed…”
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ATP hydrolysis-linked structural changes in the N-terminal part of the gamma subunit of Escherichia coli F1-ATPase examined by cross-linking studies by AGGELER, R, CAPALDI, R. A

“…A mutant of Escherichia coli F1-ATPase (ECF1) in which the serine residue in position 8 of the gamma subunit has been replaced by a cysteine residue (gamma…”
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Switching of bovine cytochrome c oxidase subunit VIa isoforms in skeletal muscle during development by Ewart, G.D., Zhang, Y.-Z., Capaldi, R.A.

“…A cDNA encoding the liver isoform of bovine cytochrome c oxidase subunit VIa (VIaL) was cloned from bovine liver RNA by reverse transcription and the…”
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Large conformational changes of the epsilon subunit in the bacterial F1F0 ATP synthase provide a ratchet action to regulate this rotary motor enzyme by Tsunoda, S P, Rodgers, A J, Aggeler, R, Wilce, M C, Yoshida, M, Capaldi, R A

“…The F(1)F(0) ATP synthase is the smallest motor enzyme known. Previous studies had established that the central stalk, made of the gamma and epsilon subunits…”
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