Search Results - "CANNE, Lynne E"

Extending the Applicability of Native Chemical Ligation by Canne, Lynne E, Bark, Steven J, Kent, Stephen B. H

“…A more general approach to native (amide-forming) chemical ligation of unprotected peptide segments is described that extends the technique beyond the…”
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Chemical Protein Synthesis by Solid Phase Ligation of Unprotected Peptide Segments by Canne, Lynne E, Botti, Paolo, Simon, Reyna J, Chen, Yijun, Dennis, Edward A, Kent, Stephen B. H

“…In this paper we describe “solid phase chemical ligation” (SPCL), the application of the principles of polymer-supported organic synthesis to the construction…”
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Total Chemical Synthesis of a Unique Transcription Factor-Related Protein: cMyc-Max by Canne, Lynne E, Ferre- D'Amare, Adrian R, Burley, Stephen K, Kent, Stephen B. H

“…cMyc and Max are proteins that regulate gene expression by associating to form noncovalent dimers that bind to specific regions of double-stranded DNA, thus…”
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Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1 by FOLKES, Adrian, BROWN, S. David, LEAHY, James W, MACH, Morrison, MATTHEWS, David, PRISBYLLA, Michael P, SANDERSON, Jason, SIMON, Reyna J, TESFAI, Zerom, VICKER, Nigel, WANG, Shouming, WEBB, Robert R, CANNE, Lynne E, CHARLTON, Peter, CHAN, Jocelyn, ENGELHARDT, Erin, EPSHTEYN, Sergey, FAINT, Richard, GOLEC, Julian, HANEL, Art, KEARNEY, Patrick

“…We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These…”
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A general method for the synthesis of thioester resin linkers for use in the solid phase synthesis of peptide-α-thioacids by Canne, Lynne E., Walker, Sharon M., Kent, Stephen B.H.

“…A generalized procedure for the synthesis of thioester linkers for use in stepwise solid phase peptide synthesis is reported. The linkers are compatible with…”
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Synthesis of a versatile purification handle for use with Boc chemistry solid phase peptide synthesis by Canne, Lynne E., Winston, Rachel L., Ken, Stephen B.H.

“…The synthesis of a versatile handle for the purification of synthetic peptides is described. The Boc-aminoethylsulfonylethyloxycarbonyl handle is coupled to…”
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