Search Results - "CANE, P. A"

The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease by OHUMA, E. O, OKIRO, E. A, OCHOLA, R, SANDE, C. J, CANE, P. A, MEDLEY, G. F, BOTTOMLEY, C, NOKES, D. J

“…This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the…”
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Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding by MUNYWOKI, P. K., KOECH, D. C., AGOTI, C. N., KIBIRIGE, N., KIPKOECH, J., CANE, P. A., MEDLEY, G. F., NOKES, D. J.

“…RSV is the most important viral cause of pneumonia and bronchiolitis in children worldwide and has been associated with significant disease burden. With the…”
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Emergence and Evolution of Enfuvirtide Resistance following Long-Term Therapy Involves Heptad Repeat 2 Mutations within gp41 by Xu, L, Pozniak, A, Wildfire, A, Stanfield-Oakley, S A, Mosier, S M, Ratcliffe, D, Workman, J, Joall, A, Myers, R, Smit, E, Cane, P A, Greenberg, M L, Pillay, D

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Kinetics of the Neutralizing Antibody Response to Respiratory Syncytial Virus Infections in a Birth Cohort by Sande, C.J., Mutunga, M.N., Okiro, E.A., Medley, G.F., Cane, P.A., Nokes, D.J.

“…The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the…”
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Respiratory Syncytial Virus Infection and Disease in Infants and Young Children Observed from Birth in Kilifi District, Kenya by Nokes, D. James, Okiro, Emelda A., Ngama, Mwanajuma, Ochola, Rachel, White, Lisa J., Scott, Paul D., English, Michael, Cane, Patricia A., Medley, Graham F.

“…Background. In developing countries, there are few data that characterize the disease burden attributable to respiratory syncytial virus (RSV) and clearly…”
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The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection by WHITE, L. J., WARIS, M., CANE, P. A., NOKES, D. J., MEDLEY, G. F.

“…Human respiratory syncytial virus (hRSV) transmission dynamics are inherently cyclical, and the observed genetic diversity (between groups A and B) also…”
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Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease by CANE, P. A, VAN DEN HOOGEN, B. G, CHAKRABARTI, S, FEGAN, C. D, OSTERHAUS, A. D. M. E

“…Respiratory viruses are increasingly recognized as a cause of pneumonitis following haematopoietic stem cell transplantation (HSCT). However, frequently, no…”
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Resistance to Antiviral Drugs in Herpes Simplex Virus Infections among Allogeneic Stem Cell Transplant Recipients: Risk Factors and Prognostic Significance by Chakrabarti, Suparno, Pillay, Deenan, Ratcliffe, Daina, Cane, Patricia A., Collingham, Kathryn E., Milligan, Donald W.

“…Herpes simplex virus (HSV) infections in 75 allogeneic stem cell transplant recipients were analyzed. Sixteen patients developed HSV disease following…”
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Evaluating the extent of potential resistance to pre‐exposure prophylaxis within the UK HIV‐1‐infectious population of men who have sex with men by Dolling, D, Phillips, AN, Delpech, V, Pillay, D, Cane, PA, Crook, AM, Shepherd, J, Fearnhill, E, Hill, T, Dunn, D

“…Objectives Recent studies have shown that pre‐exposure prophylaxis (PrEP) can substantially reduce the chance of acquiring HIV infection. However, PrEP…”
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Increased detection of the HIV‐1 reverse transcriptase M184V mutation using mutation‐specific minority assays in a UK surveillance study suggests evidence of unrecognized transmitted drug resistance by Buckton, AJ, Prabhu, D, Motamed, C, Harris, RJ, Hill, C, Murphy, G, Parry, JV, Johnson, JA, Lowndes, CM, Gill, N, Pillay, D, Cane, PA

“…Objectives The aim of the study was to estimate the levels of transmitted drug resistance (TDR) in HIV‐1 using very sensitive assays to detect minority…”
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Evolution of subgroup A respiratory syncytial virus: evidence for progressive accumulation of amino acid changes in the attachment protein by Cane, P A, Pringle, C R

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Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein by Melero, J A, García-Barreno, B, Martínez, I, Pringle, C R, Cane, P A

“…Human respiratory syncytial virus (HRSV) is a major cause of lower respiratory tract disease in babies and vulnerable adults. A characteristic feature of HRSV…”
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Resistance-Associated Mutations in the Human Immunodeficiency Virus Type 1 Subtype C Protease Gene from Treated and Untreated Patients in the United Kingdom by CANE, Patricia A, DE RUITER, Annemiek, RICH, Philip, WISELKA, Martin, FOX, Ray, PILLARY, Deenan

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Analysis of respiratory syncytial virus strain variation in successive epidemics in one city by CANE, P. A, MATTHEWS, D. A, PRINGLE, C. R

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Genotypic antiretroviral drug resistance testing at low viral loads in the UK by Cane, PA, Kaye, S, Smit, E, Tilston, P, Kirk, S, Shepherd, J, Hopkins, M, Zhang, H, Geretti, AM

“…Background Antiretroviral drug resistance testing is recommended in HIV‐1 infected patients failing therapy in order to inform treatment selection. Although…”
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Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses by Cane, P. A, Matthews, D. A, Pringle, C. R

“…Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K. We have previously classified isolates from a respiratory syncytial (RS) virus…”
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Poor penetration of the male genital tract by HIV-1 protease inhibitors by TAYLOR, S, BACK, D. J, WORKMAN, J, DRAKE, S. M, WHITE, D. J, CHOUDHURY, B, CANE, P. A, BEARDS, G. M, HALIFAX, K, PILLAY, D

“…In conclusion, the poor penetration of antivirals may contribute to a 'compartmental' effect, whereby HIV replication and evolution in the genital tract is…”
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Evolution of lamivudine-resistant hepatitis B virus and HIV-1 in co-infected individuals : an analysis of the CAESAR study by PILLAY, D, CANE, P. A, RATCLIFFE, D, ATKINS, M, COOPER, D

“…Objectives: Lamivudine has potent activity against HIV-1 and hepatitis B virus (HBV). Co-infection with these two viruses is common, and this may therefore…”
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Selection of Multiresistant Hepatitis B Virus during Sequential Nucleoside-Analogue Therapy by Mutimer, David, Pillay, Deenan, Cook, Pamela, Ratcliffe, Daina, O'Donnell, Katharina, Dowling, Damien, Shaw, Jean, Elias, Elwyn, Cane, Patricia A.

“…Hepatitis B virus (HBV) drug resistance to lamivudine is always accompanied by mutations in the viral polymerase gene at position 550, termed group 1 (M550V…”
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Recombinant strains of HIV type 1 in the United Kingdom by Barlow, K L, Tatt, I D, Cane, P A, Pillay, D, Clewley, J P

“…Twenty-five recombinant (mosaic) HIV-1 genomes were detected among 151 samples comprising 118 non-B subtype sequences and 33 samples containing subtype B…”
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