Search Results - "CAMPOCHIARO, P. A"

Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders by Campochiaro, P A

“…The eye is a relatively isolated tissue compartment, which provides advantages for utilization of small interfering RNA (siRNA). Feasibility of using siRNA for…”
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Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1 by SHEN, J, SAMUL, R, VARGEESE, C, GOMEZ, A, BOUHANA, K, AITCHISON, R, PAVCO, P, CAMPOCHIARO, P. A, SILVA, R. L, AKIYAMA, H, LIU, H, SAISHIN, Y, HACKETT, S. F, ZINNEN, S, KOSSEN, K, FOSNAUGH, K

“…In this study, we used small interfering RNA (siRNA) directed against vascular endothelial growth factor receptor 1 (vegfr1) mRNA to investigate the role of…”
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Month-6 primary outcomes of the READ-3 study (Ranibizumab for Edema of the mAcula in Diabetes—Protocol 3 with high dose) by Do, D V, Sepah, Y J, Boyer, D, Callanan, D, Gallemore, R, Bennett, M, Marcus, D M, Halperin, L, Sadiq, M A, Rajagopalan, N, Campochiaro, P A, Nguyen, Q D

“…Purpose To compare 2.0 mg ranibizumab (RBZ) injections with 0.5 mg RBZ for eyes with center-involved diabetic macular edema (DME) and a central subfield…”
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An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema by Do, D V, Nguyen, Q D, Shah, S M, Browning, D J, Haller, J A, Chu, K, Yang, K, Cedarbaum, J M, Vitti, R L, Ingerman, A, Campochiaro, P A

“…The aim of the study was to assess the safety and bioactivity of a single intravitreal injection of vascular endothelial growth factor (VEGF) Trap-Eye in…”
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Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier by NAMBU, H, NAMBU, R, OSHIMA, Y, HACKETT, S. F, OKOYE, G, WIEGAND, S, YANCOPOULOS, G, ZACK, D. J, CAMPOCHIARO, P. A

“…Several retinal and choroidal diseases are potentially treatable by intraocular delivery of genes whose products may counter or neutralize abnormal gene…”
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VEGF Is Major Stimulator in Model of Choroidal Neovascularization by Kwak, Nohoon, Okamoto, Naoyuki, Wood, Jeanette M, Campochiaro, Peter A

“…Vascular endothelial growth factor (VEGF) is upregulated by hypoxia and is a major stimulatory factor for retinal neovascularization in ischemic retinopathies…”
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Nonviral ocular gene transfer by KACHI, S, OSHIMA, Y, ESUMI, N, KACHI, M, ROGERS, B, ZACK, D. J, CAMPOCHIARO, P. A

“…In this study, we explored the use of electroporation or media that promote lipoplex formation for nonviral gene transfer in the eye. There was no detectable…”
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Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization by Okamoto, N, Tobe, T, Hackett, SF, Ozaki, H, Vinores, MA, LaRochelle, W, Zack, DJ, Campochiaro, PA

“…Vascular endothelial growth factor (VEGF) has been implicated in retinal neovascularization (NV), but it has been difficult to produce retinal NV with…”
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Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization by GEHLBACH, P, DEMETRIADES, A. M, YAMAMOTO, S, DEERING, T, DUH, E. J, YANG, H. S, CINGOLANI, C, LAI, H, WEI, L, CAMPOCHIARO, P. A

“…Gene transfer provides an exciting new approach for the treatment of retinal and choroidal diseases. Two areas of concern are the potential for vector-related…”
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Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization by Ozaki, Hiroaki, Seo, Man-Seong, Ozaki, Keiko, Yamada, Haruhiko, Yamada, Eri, Okamoto, Naoyuki, Hofmann, Francesco, Wood, Jeanette M., Campochiaro, Peter A.

“…Retinal vasculogenesis and ischemic retinopathies provide good model systems for study of vascular development and neovascularization (NV), respectively…”
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Neurotrophic Factors Cause Activation of Intracellular Signaling Pathways in Muller Cells and Other Cells of the Inner Retina, but Not Photoreceptors by Wahlin, Karl J, Campochiaro, Peter A, Zack, Donald J, Adler, Ruben

“…Intravitreal injection of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast growth factor (FGF2) promotes…”
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Sustained expression after nonviral ocular gene transfer using mammalian promoters by KACHI, S, ESUMI, N, ZACK, D. J, CAMPOCHIARO, P. A

“…The CMV promoter drives high transgene expression and is one of the most commonly used promoters for gene transfer. Tissue-specific mammalian promoters provide…”
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Gene transfer for ocular neovascularization and macular edema by Campochiaro, P A

“…Diseases complicated by abnormal growth of vessels or excessive leakage are the most prevalent cause of moderate or severe vision loss in developed countries…”
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Targeted Disruption of the FGF2 Gene Does Not Prevent Choroidal Neovascularization in a Murine Model by Tobe, Takao, Ortega, Sagrario, Luna, Jose D., Ozaki, Hiroaki, Okamoto, Naoyuki, Derevjanik, Nancy L., Vinores, Stanley A., Basilico, Claudio, Campochiaro, Peter A.

“…Choroidal neovascularization (CNV) is the major cause of severe visual loss in patients with age-related macular degeneration. Laser treatment is helpful for a…”
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Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor by Seo, Man Seong, Kwak, Nohoon, Ozaki, Hiroaki, Yamada, Haruhiko, Okamoto, Naoyuki, Yamada, Eri, Fabbro, Doriano, Hofmann, Francesco, Wood, Jeanette M., Campochiaro, Peter A.

“…The most common cause of new blindness in young patients is retinal neovascularization, and in the elderly is choroidal neovascularization. Therefore, there…”
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Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab by Channa, R, Sophie, R, Khwaja, A A, Do, D V, Hafiz, G, Nguyen, Q D, Campochiaro, P A

“…Purpose To identify factors associated with visual outcomes in patients with diabetic macular edema (DME) treated with ranibizumab (RBZ) in the Ranibizumab for…”
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Cloning and Characterization of a Secreted Frizzled-Related Protein that is Expressed by the Retinal Pigment Epithelium by Chang, Jinghua T., Esumi, Noriko, Moore, Kathryn, Li, Yuanyuan, Zhang, Suiyuan, Chew, Christina, Goodman, Barbara, Rattner, Amir, Moody, Sally, Stetten, Gail, Campochiaro, Peter A., Zack, Donald J.

“…The Wnt/frizzled cell signaling pathway has been implicated in the determination of polarity in a number of systems, including the Drosophila retina. The…”
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Intravitreal Sustained Release of VEGF Causes Retinal Neovascularization in Rabbits and Breakdown of the Blood– Retinal Barrier in Rabbits and Primates by OZAKI, HIROAKI, HAYASHI, HIDEYUKI, VINORES, STANLEY A., MOROMIZATO, YASUFUMI, CAMPOCHIARO, PETER A., OSHIMA, KENJI

“…Vascular endothelial growth factor (VEGF) has been identified as a possible mediator of retinal neovascularization (NV), but it is not certain if VEGF alone is…”
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The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration by Campochiaro, P A, Soloway, P, Ryan, S J, Miller, J W

“…Laser photocoagulation and several experimental treatments for choroidal neovascularization (CNV) in patients with age-related macular degeneration attempt to…”
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Oxidative damage in age-related macular degeneration by Shen, J K, Dong, A, Hackett, S F, Bell, W R, Green, W R, Campochiaro, P A

“…Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with…”
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