Search Results - "CAMONIS, Jacques"

A review and perspective paper: Ras oncogene gets modest, from kingpin to mere henchman by Camonis, Jacques H., Aushev, Vasily N., Zueva, Elina, Zalcman, Gérard

“…The concomitant activation of both the YAP1 co-transcription factor and RAS GTPases is a hallmark of several aggressive cancers, though the intricacies of…”
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RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly by Bodemann, Brian O., Orvedahl, Anthony, Cheng, Tzuling, Ram, Rosalyn R., Ou, Yi-Hung, Formstecher, Etienne, Maiti, Mekhala, Hazelett, C. Clayton, Wauson, Eric M., Balakireva, Maria, Camonis, Jacques H., Yeaman, Charles, Levine, Beth, White, Michael A.

“…The study of macroautophagy in mammalian cells has described induction, vesicle nucleation, and membrane elongation complexes as key signaling intermediates…”
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RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway by Dubois, Fatéméh, Keller, Maureen, Calvayrac, Olivier, Soncin, Fabrice, Hoa, Lily, Hergovich, Alexander, Parrini, Maria-Carla, Mazières, Julien, Vaisse-Lesteven, Mélissa, Camonis, Jacques, Levallet, Guénaëlle, Zalcman, Gérard

“…Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer…”
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The hippo kinase STK38 ensures functionality of XPO1 by Martin, Alexandre PJ, Camonis, Jacques H

“…The proper segregation of basic elements such as the compartmentalization of the genome and the shuttling of macromolecules between the nucleus and the…”
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Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers by Lefort, Sylvain, Joffre, Carine, Kieffer, Yann, Givel, Anne-Marie, Bourachot, Brigitte, Zago, Giulia, Bieche, Ivan, Dubois, Thierry, Meseure, Didier, Vincent-Salomon, Anne, Camonis, Jacques, Mechta-Grigoriou, Fatima

“…The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with…”
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An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation by Rosse, Carine, Formstecher, Etienne, Boeckeler, Katrina, Zhao, Yingming, Kremerskothen, Joachim, White, Michael D, Camonis, Jacques H, Parker, Peter J

“…Atypical protein kinase C (aPKC) isoforms have been implicated in cell polarisation and migration through association with Cdc42 and Par6. In distinct…”
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Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments by Nguyen, Marie, De Ninno, Adele, Mencattini, Arianna, Mermet-Meillon, Fanny, Fornabaio, Giulia, Evans, Sophia S., Cossutta, Mélissande, Khira, Yasmine, Han, Weijing, Sirven, Philémon, Pelon, Floriane, Di Giuseppe, Davide, Bertani, Francesca Romana, Gerardino, Annamaria, Yamada, Ayako, Descroix, Stéphanie, Soumelis, Vassili, Mechta-Grigoriou, Fatima, Zalcman, Gérard, Camonis, Jacques, Martinelli, Eugenio, Businaro, Luca, Parrini, Maria Carla

“…A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging…”
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The STK38–XPO1 axis, a new actor in physiology and cancer by Martin, Alexandre PJ, Aushev, Vasily N., Zalcman, Gérard, Camonis, Jacques H.

“…The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as…”
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STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes by Martin, Alexandre PJ, Jacquemyn, Maarten, Lipecka, Joanna, Chhuon, Cerina, Aushev, Vasily N, Meunier, Brigitte, Singh, Manish K, Carpi, Nicolas, Piel, Matthieu, Codogno, Patrice, Hergovich, Alexander, Parrini, Maria Carla, Zalcman, Gerard, Guerrera, Ida Chiara, Daelemans, Dirk, Camonis, Jacques H

“…STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context‐dependent…”
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NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells by Keller, Maureen, Dubois, Fatéméh, Teulier, Sylvain, Martin, Alexandre P J, Levallet, Jérôme, Maille, Elodie, Brosseau, Solenn, Elie, Nicolas, Hergovich, Alexander, Bergot, Emmanuel, Camonis, Jacques, Zalcman, Gérard, Levallet, Guénaëlle

“…RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are…”
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The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy by Joffre, Carine, Dupont, Nicolas, Hoa, Lily, Gomez, Valenti, Pardo, Raul, Gonçalves-Pimentel, Catarina, Achard, Pauline, Bettoun, Audrey, Meunier, Brigitte, Bauvy, Chantal, Cascone, Ilaria, Codogno, Patrice, Fanto, Manolis, Hergovich, Alexander, Camonis, Jacques

“…Autophagy plays key roles in development, oncogenesis, cardiovascular, metabolic, and neurodegenerative diseases. Hence, understanding how autophagy is…”
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RalB directly triggers invasion downstream Ras by mobilizing the Wave complex by Zago, Giulia, Veith, Irina, Singh, Manish Kumar, Fuhrmann, Laetitia, De Beco, Simon, Remorino, Amanda, Takaoka, Saori, Palmeri, Marjorie, Berger, Frédérique, Brandon, Nathalie, El Marjou, Ahmed, Vincent-Salomon, Anne, Camonis, Jacques, Coppey, Mathieu, Parrini, Maria Carla

“…The two Ral GTPases, RalA and RalB, have crucial roles downstream Ras oncoproteins in human cancers; in particular, RalB is involved in invasion and…”
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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells by Colland, Frédéric, Formstecher, Etienne, Jacq, Xavier, Reverdy, Céline, Planquette, Cécile, Conrath, Susan, Trouplin, Virginie, Bianchi, Julie, Aushev, Vasily N, Camonis, Jacques, Calabrese, Alessandra, Borg-Capra, Catherine, Sippl, Wolfgang, Collura, Vincent, Boissy, Guillaume, Rain, Jean-Christophe, Guedat, Philippe, Delansorne, Rémi, Daviet, Laurent

“…Deregulation of the ubiquitin/proteasome system has been implicated in the pathogenesis of many human diseases, including cancer. Ubiquitin-specific proteases…”
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Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death by Veith, Irina, Mencattini, Arianna, Picant, Valentin, Serra, Marco, Leclerc, Marine, Comes, Maria Colomba, Mami-Chouaib, Fathia, Camonis, Jacques, Descroix, Stéphanie, Shirvani, Hamasseh, Mechta-Grigoriou, Fatima, Zalcman, Gérard, Parrini, Maria Carla, Martinelli, Eugenio

“…The emerging tumor-on-chip (ToC) approaches allow to address biomedical questions out of reach with classical cell culture techniques: in biomimetic 3D…”
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Localization of RalB signaling at endomembrane compartments and its modulation by autophagy by Singh, Manish Kumar, Martin, Alexandre P. J., Joffre, Carine, Zago, Giulia, Camonis, Jacques, Coppey, Mathieu, Parrini, Maria Carla

“…The monomeric GTPase RalB controls crucial physiological processes, including autophagy and invasion, but it still remains unclear how this multi-functionality…”
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RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases by O Santos, Adriana, Parrini, Maria Carla, Camonis, Jacques

“…The human genome contains six genes coding for proteins validated in vitro as specific activators of the small GTPases "Ras-related protein Ral-A" and…”
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Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs by Cascone, Ilaria, Selimoglu, Rasim, Ozdemir, Cafer, Del Nery, Elaine, Yeaman, Charles, White, Michael, Camonis, Jacques

“…The Ras family G‐proteins RalA and RalB make critical non‐overlapping contributions to the generation of a tumorigenic regulatory network, supporting bypass of…”
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The Epsin Family of Endocytic Adaptors Promotes Fibrosarcoma Migration and Invasion by Coon, Brian G., Burgner, John, Camonis, Jacques H., Aguilar, R. Claudio

“…Abnormalities in the process of endocytosis are classically linked to malignant transformation through the deficient down-regulation of signaling receptors…”
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VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX by Bonin, Florian, Taouis, Karim, Azorin, Paula, Petitalot, Ambre, Tariq, Zakia, Nola, Sebastien, Bouteille, Nadège, Tury, Sandrine, Vacher, Sophie, Bièche, Ivan, Rais, Khadija Ait, Pierron, Gaelle, Fuhrmann, Laetitia, Vincent-Salomon, Anne, Formstecher, Etienne, Camonis, Jacques, Lidereau, Rosette, Lallemand, François, Driouch, Keltouma

“…The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its…”
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Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras by Singh, Manish Kumar, Zago, Giulia, Veith, Irina, Camonis, Jacques, Coppey, Mathieu, Parrini, Maria Carla

“…Autophagy is a physiological degradation process that removes unnecessary or dysfunctional components of cells. It is important for normal cellular homeostasis…”
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