Search Results - "CAMDEN, JEAN M."

Purinergic receptors as potential therapeutic targets in Alzheimer's disease by Woods, Lucas T., Ajit, Deepa, Camden, Jean M., Erb, Laurie, Weisman, Gary A.

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive ability and is a serious cause of…”
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Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation by Woods, Lucas T, Camden, Jean M, El-Sayed, Farid G, Khalafalla, Mahmoud G, Petris, Michael J, Erb, Laurie, Weisman, Gary A

“…Transforming growth factor-β (TGF-β) is a multi-functional cytokine with a well-described role in the regulation of tissue fibrosis and regeneration in the…”
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P2X7 receptor activation induces inflammatory responses in salivary gland epithelium by Woods, Lucas T, Camden, Jean M, Batek, Josef M, Petris, Michael J, Erb, Laurie, Weisman, Gary A

“…Inflammation of the salivary gland is a well-documented aspect of salivary gland dysfunction that occurs in Sjogren's syndrome (SS), an autoimmune disease, and…”
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P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction by Khalafalla, Mahmoud G, Woods, Lucas T, Jasmer, Kimberly J, Forti, Kevin Muñoz, Camden, Jean M, Jensen, Janicke L, Limesand, Kirsten H, Galtung, Hilde K, Weisman, Gary A

“…Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral…”
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Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling by Gilman, Kristy E., Camden, Jean M., Woods, Lucas T., Weisman, Gary A., Limesand, Kirsten H.

“…Annually, >600,000 new cases of head and neck cancer (HNC) are diagnosed worldwide with primary treatment being surgery and radiotherapy. During ionizing…”
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P2Y2 Nucleotide Receptors Mediate Metalloprotease-dependent Phosphorylation of Epidermal Growth Factor Receptor and ErbB3 in Human Salivary Gland Cells by Ratchford, Ann M., Baker, Olga J., Camden, Jean M., Rikka, Shivaji, Petris, Michael J., Seye, Cheikh I., Erb, Laurie, Weisman, Gary A.

“…The G protein-coupled receptor P2Y2 nucleotide receptor (P2Y2R) has been shown to be up-regulated in a variety of tissues in response to stress or injury…”
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Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland by Catalán, Marcelo A., Nakamoto, Tetsuji, Gonzalez‐Begne, Mireya, Camden, Jean M., Wall, Susan M., Clarke, Lane L., Melvin, James E.

“…Cystic fibrosis is caused by mutations in CFTR, the cystic fibrosis transmembrane conductance regulator gene. Disruption of CFTR-mediated anion conductance…”
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Cell Sheets Restore Secretory Function in Wounded Mouse Submandibular Glands by Dos Santos, Harim T, Kim, Kyungsook, Okano, Teruo, Camden, Jean M, Weisman, Gary A, Baker, Olga J, Nam, Kihoon

“…Thermoresponsive cell culture plates release cells as confluent living sheets in response to small changes in temperature, with recovered cell sheets retaining…”
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P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications by Woods, Lucas T., Forti, Kevin Muñoz, Shanbhag, Vinit C., Camden, Jean M., Weisman, Gary A.

“…Purinergic receptors for extracellular nucleotides and nucleosides contribute to a vast array of cellular and tissue functions, including cell proliferation,…”
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P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy by Khalafalla, Mahmoud G., Woods, Lucas T., Camden, Jean M., Khan, Aslam A., Limesand, Kirsten H., Petris, Michael J., Erb, Laurie, Weisman, Gary A.

“…Salivary gland inflammation is a hallmark of Sjögren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary…”
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Nucleotides released from Aβ1-42-treated microglial cells increase cell migration and Aβ1-42 uptake through P2Y2 receptor activation by Kim, Hye Jung, Ajit, Deepa, Peterson, Troy S., Wang, Yanfang, Camden, Jean M., Gibson Wood, W., Sun, Grace Y., Erb, Laurie, Petris, Michael, Weisman, Gary A.

“…J. Neurochem. (2012) 121, 228–238. Amyloid β‐protein (Aβ) deposits in brains of Alzheimer’s disease patients generate proinflammatory cytokines and chemokines…”
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P2X7 receptor deletion suppresses γ-radiation-induced hyposalivation by Gilman, Kristy E, Camden, Jean M, Klein, Rob R, Zhang, Qionghui, Weisman, Gary A, Limesand, Kirsten H

“…Head and neck cancer treatments typically involve a combination of surgery and radiotherapy, often leading to collateral damage to nearby tissues causing…”
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Early Dry Eye Disease Onset in a NOD.H-2h4 Mouse Model of Sjögren's Syndrome by Li, Lili, Jasmer, Kimberly J, Camden, Jean M, Woods, Lucas T, Martin, Adam L, Yang, Yong, Layton, Maria, Petris, Michael J, Baker, Olga J, Weisman, Gary A, Petris, Carisa K

“…PurposeTo develop a mouse model of human dry eye disease (DED) for investigation of sex differences in autoimmune-associated dry eye pathology. MethodsOcular…”
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Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer by Forti, Kevin Muñoz, Woods, Lucas T., Jasmer, Kimberly J., Camden, Jean M., Weisman, Gary A.

“…Head and neck squamous cell carcinomas (HNSCCs) are a heterogenous group of tumors and among the top 10 most common cancers and they arise from the epithelial…”
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P2Y2 receptors mediate nucleotide-induced EGFR phosphorylation and stimulate proliferation and tumorigenesis of head and neck squamous cell carcinoma cell lines by Woods, Lucas T., Jasmer, Kimberly J., Muñoz Forti, Kevin, Shanbhag, Vinit C., Camden, Jean M., Erb, Laurie, Petris, Michael J., Weisman, Gary A.

“…•P2Y2Rs mediate EGFR and ERK1/2 phosphorylation in CAL27 and FaDu HNSCC cells.•Metalloprotease or Src inhibition blocks nucleotide-induced EGFR…”
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P2Y2 receptor antagonism resolves sialadenitis and improves salivary flow in a Sjögren’s syndrome mouse model by Jasmer, Kimberly J., Woods, Lucas T., Forti, Kevin Muñoz, Martin, Adam L., Camden, Jean M., Colonna, Marco, Weisman, Gary A.

“…•Systemic or localized delivery of the selective P2Y2R antagonist, AR-C118925, were evaluated in the NOD.H-2h4,IFNγ−/−,CD28−/− SS mouse model.•Systemic…”
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P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation by Weisman, Gary A., Camden, Jean M., Peterson, Troy S., Ajit, Deepa, Woods, Lucas T., Erb, Laurie

“…Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y…”
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New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland by Kayes, Timothy Daniel, Weisman, Gary A, Camden, Jean M, Woods, Lucas T, Bredehoeft, Cole, Downey, Edward F, Cole, James, Braley-Mullen, Helen

“…Sixty to seventy percent of IFN-γ(-/-) NOD.H-2h4 mice given sodium iodide (NaI)-supplemented water develop a slow onset autoimmune thyroid disease,…”
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Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line by Baker, Olga J, Camden, Jean M, Redman, Robert S, Jones, Jonathan E, Seye, Cheikh I, Erb, Laurie, Weisman, Gary A

“…Sjögren's syndrome (SS) is an autoimmune disorder characterized by inflammation and dysfunction of salivary glands, resulting in impaired secretory function…”
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Loss of P2Y2 Nucleotide Receptors Enhances Early Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease by Ajit, Deepa, Woods, Lucas T., Camden, Jean M., Thebeau, Christina N., El-Sayed, Farid G., Greeson, Glen W., Erb, Laurie, Petris, Michael J., Miller, Douglas C., Sun, Grace Y., Weisman, Gary A.

“…Neuroinflammation is a prominent feature in Alzheimer's disease (AD) and activation of the brain's innate immune system, particularly microglia, has been…”
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