Search Results - "CALVO, JUAN R."

The role of melatonin in the cells of the innate immunity: a review by Calvo, Juan R., González-Yanes, C., Maldonado, M. D.

“…Melatonin is the major secretory product synthesized and secreted by the pineal gland and shows both a wide distribution within phylogenetically distant…”
Get full text

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance by Carrillo‐Vico, Antonio, Calvo, Juan R., Abreu, Pedro, Lardone, Patricia J., García‐Mauriño, Sofía, Reiter, Russel J., Guerrero, Juan M.

“…It has been historically assumed that the pineal gland is the major source of melatonin (N‐acetyl‐ 5‐methoxytryptamine) in vertebrates. Melatonin plays a…”
Get full text

Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects by Carrillo-Vico, Antonio, Lardone, Patricia J., Naji, Latifa, Fernández-Santos, José M., Martín-Lacave, Inés, Guerrero, Juan M., Calvo, Juan R.

“…:  Septic shock, the most severe problem of sepsis, is a lethal condition caused by the interaction of a pathogen‐induced long chain of sequential…”
Get full text

Expression of membrane and nuclear melatonin receptors in mouse peripheral organs by Naji, Latifa, Carrillo-Vico, Antonio, Guerrero, Juan M, Calvo, Juan R

“…Previous studies have shown that melatonin acts through specific receptors, including MT 1 and MT 2 membrane receptors as well as a nuclear receptor belonging…”
Get full text

Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro by Leon-Blanco, Mercedes M., Guerrero, Juan M., Reiter, Russel J., Calvo, Juan R., Pozo, David

“…: In this study for the first time the relationship between melatonin and telomerase activity was investigated. Melatonin exhibits oncostatic properties, but…”
Get full text

Immunoregulatory properties of melatonin in the humoral immune system: A narrative review by Calvo, Juan R., Maldonado, María D.

“…•B lymphocytes express both membrane and nuclear receptors for melatonin.•Melatonin modulates different biological actions in B lymphocytes.•Melatonin…”
Get full text

Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines by García-Mauriño, Sofía, Pozo, David, Calvo, Juan R., Guerrero, Juan M.

“…The report shows that melatonin enhances IL‐2 and IL‐6 production by two human lymphocytic (Jurkat) and monocytic (U937) cell lines via a nuclear…”
Get full text

Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum by Maldonado, Maria D, Moreno, Hector, Calvo, Juan R

“…Summary Background & aim Melatonin is a molecule with antioxidative properties including direct free radical scavenging and indirect stimulatory actions on a…”
Get full text

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide modulate endotoxin-induced IL-6 production by murine peritoneal macrophages by Martínez, Carmen, Delgado, Mario, Pozo, David, Leceta, Javier, Calvo, Juan R., Ganea, Doina, Gomariz, Rosa P.

“…Vasoactive intestinal peptide (VIP) is a neuropeptide synthesized by immune cells that can modulate several immune aspects, including the function of cells…”
Get full text

Melatonin and Its Relation to the Immune System and Inflammation by REITER, RUSSEL J., CALVO, JUAN R., KARBOWNIK, MALGORZATA, QI, WENBO, TAN, DUN XIAN

“…: Melatonin (N‐acetyl‐5‐methoxytryptamine) was initially thought to be produced exclusively in the pineal gland. Subsequently its synthesis was demonstrated in…”
Get full text

Human Lymphocyte-Synthesized Melatonin Is Involved in the Regulation of the Interleukin-2/Interleukin-2 Receptor System by Carrillo-Vico, Antonio, Lardone, Patricia J., Fernández-Santos, José M., Martín-Lacave, Inés, Calvo, Juan R., Karasek, Michal, Guerrero, Juan M.

“…Since melatonin was first isolated in 1958 up to the last few years, this substance was considered a hormone exclusive to the pineal gland. Although melatonin…”
Get full text

Melatonin counteracts the inhibitory effect of PGE2 on IL‐2 production in human lymphocytes via its mt1 membrane receptor by Carrillo‐Vico, Antonio, García‐Mauriño, Sofía, Calvo, Juan R., Guerrero, Juan M.

“…ABSTRACT It is well known that melatonin plays a fundamental role in human neuro‐immunomodulation. Thus, melatonin regulates the production of a large number…”
Get full text

Significance of melatonin in antioxidative defense system: reactions and products by Tan, D X, Manchester, L C, Reiter, R J, Qi, W B, Karbownik, M, Calvo, J R

“…Melatonin is a potent endogenous free radical scavenger, actions that are independent of its many receptor-mediated effects. In the last several years,…”
Get more information

Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo by Reiter, R J, Tan, D X, Qi, W, Manchester, L C, Karbownik, M, Calvo, J R

“…This brief resume summarizes the evidence which shows that melatonin is a significant free radical scavenger and antioxidant at both physiological and…”
Get more information

Chromium(III)-Induced 8-Hydroxydeoxyguanosine in DNA and Its Reduction by Antioxidants: Comparative Effects of Melatonin, Ascorbate, and Vitamin E by Qi, Wenbo, Reiter, Russel J., Tan, Dun-Xian, Garcia, Joaquin J., Manchester, Lucien C., Karbownik, Malgorzata, Calvo, Juan R.

“…Chromium compounds are well documented carcinogens. Cr(III) is more reactive than Cr(VI) toward DNA under in vitro conditions. In the present study, we…”
Get full text

Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells by Garcia-Mauriño, Sofia, Gonzalez-Haba, Maria G, Calvo, Juan R, Goberna, Raimundo, Guerrero, Juan M

“…Many functional studies show that melatonin plays a fundamental role in neuroimmunomodulation. In this paper, we have extended our studies on the influence of…”
Get full text

Melatonin triggers Crohn's disease symptoms by Calvo, Juan R, Guerrero, Juan M, Osuna, Carmen, Molinero, Patrocinio, Carrillo-Vico, Antonio

Get full text

N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid peroxidation by Garcı́a, Joaquı́n J, Reiter, Russel J, Karbownik, Malgorzata, Calvo, Juan R, Ortiz, Genaro G, Tan, Dun-Xian, Martı́nez-Balları́n, Enrique, Acuña-Castroviejo, Darı́o

“…N-acetylserotonin, the immediate precursor of melatonin in the tryptophan metabolic pathway in the pineal gland, has been reported to be an antioxidant. The…”
Get full text

Immunomodulatory role of melatonin: specific binding sites in human and rodent lymphoid cells by Calvo, J R, Rafii-el-Idrissi, M, Pozo, D, Guerrero, J M

“…This paper reviews the evidence that supports the hypothesis of the existence of specific binding sites for melatonin on immune cells. These binding sites have…”
Get more information

Specific binding of melatonin by purified cell nuclei from spleen and thymus of the rat by Rafii-El-Idrissi, Mohammed, Calvo, Juan R, Harmouch, Ahmed, Garcı́a-Mauriño, Sofia, Guerrero, Juan M

“…In the present paper, we show that pineal hormone melatonin interacts with purified cell nuclei from rat spleen and thymus. Binding of 2-[ 125 I ]iodomelatonin…”
Get full text