Search Results - "CALVERT, John W"

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number by Naqvi, Nawazish, Li, Ming, Calvert, John W., Tejada, Thor, Lambert, Jonathan P., Wu, Jianxin, Kesteven, Scott H., Holman, Sara R., Matsuda, Torahiro, Lovelock, Joshua D., Howard, Wesley W., Iismaa, Siiri E., Chan, Andrea Y., Crawford, Brian H., Wagner, Mary B., Martin, David I.K., Lefer, David J., Graham, Robert M., Husain, Ahsan

“…It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby causing binucleation and limiting regenerative repair…”
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Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling by Calvert, John W, Jha, Saurabh, Gundewar, Susheel, Elrod, John W, Ramachandran, Arun, Pattillo, Christopher B, Kevil, Christopher G, Lefer, David J

“…RATIONALE:The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective…”
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H2S Protects Against Pressure Overload―Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase by KONDO, Kazuhisa, BHUSHAN, Shashi, RUI WANG, KARUSULA, Naveena, NICHOLSON, Chad K, CALVERT, John W, LEFER, David J, KING, Adrienne L, PRABHU, Sumanth D, HAMID, Tariq, KOENIG, Steven, MUROHARA, Toyoaki, PREDMORE, Benjamin L, GOJON, Gabriel

“…Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis. We investigated the…”
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Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent by King, Adrienne L., Polhemus, David J., Bhushan, Shashi, Otsuka, Hiroyuki, Kondo, Kazuhisa, Nicholson, Chad K., Bradley, Jessica M., Islam, Kazi N., Calvert, John W., Tao, Ya-Xiong, Dugas, Tammy R., Kelley, Eric E., Elrod, John W., Huang, Paul L., Wang, Rui, Lefer, David J.

“…Previous studies have demonstrated that hydrogen sulfide (H ₂S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide…”
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Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism by Hayashida, Ryo, Kondo, Kazuhisa, Morita, Sumio, Unno, Kazumasa, Shintani, Satoshi, Shimizu, Yuuki, Calvert, John W., Shibata, Rei, Murohara, Toyoaki

“…Background:Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic…”
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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function by Elrod, John W, Calvert, John W, Morrison, Joanna, Doeller, Jeannette E, Kraus, David W, Tao, Ling, Jiao, Xiangying, Scalia, Rosario, Kiss, Levente, Szabo, Csaba, Kimura, Hideo, Chow, Chi-Wing, Lefer, David J

“…The recent discovery that hydrogen sulfide (H₂S) is an endogenously produced gaseous second messenger capable of modulating many physiological processes, much…”
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Guidelines for in vivo mouse models of myocardial infarction by Lindsey, Merry L, Brunt, Keith R, Kirk, Jonathan A, Kleinbongard, Petra, Calvert, John W, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Del Re, Dominic P, Frangogiannis, Nikolaos G, Frantz, Stefan, Gumina, Richard J, Halade, Ganesh V, Jones, Steven P, Ritchie, Rebecca H, Spinale, Francis G, Thorp, Edward B, Ripplinger, Crystal M, Kassiri, Zamaneh

“…Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI…”
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Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice by CALVERT, John W, ELSTON, Marah, NICHOLSON, Chad K, GUNDEWAR, Susheel, JHA, Saurabh, ELROD, John W, RAMACHANDRAN, Arun, LEFER, David J

“…Hydrogen sulfide (H(2)S) is an endogenous signaling molecule with potent cytoprotective effects. The present study evaluated the therapeutic potential of H(2)S…”
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Adipose‐Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA‐31 by Kang, Ting, Jones, Tia M., Naddell, Clayton, Bacanamwo, Methode, Calvert, John W., Thompson, Winston E., Bond, Vincent C., Chen, Y. Eugene, Liu, Dong

“…The potential effects of stem cell‐released microvesicles (MVs) in proangiogenic therapy were explored. MVs were released from adipose‐derived stem cells…”
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Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling by Jha, Saurabh, Calvert, John W, Duranski, Mark R, Ramachandran, Arun, Lefer, David J

“…Hydrogen sulfide (H(2)S) is an endogenously produced gaseous signaling molecule with diverse physiological activity. The potential protective effects of H(2)S…”
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Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure by Gundewar, Susheel, Calvert, John W, Jha, Saurabh, Toedt-Pingel, Iris, Ji, Sang Yong, Nunez, Denise, Ramachandran, Arun, Anaya-Cisneros, Mauricio, Tian, Rong, Lefer, David J

“…Clinical studies have reported that the widely used antihyperglycemic drug metformin significantly reduces cardiac risk factors and improves clinical outcomes…”
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Bax regulates primary necrosis through mitochondrial dynamics by Whelan, Russell S, Konstantinidis, Klitos, Wei, An-Chi, Chen, Yun, Reyna, Denis E, Jha, Saurabh, Yang, Ying, Calvert, John W, Lindsten, Tullia, Thompson, Craig B, Crow, Michael T, Gavathiotis, Evripidis, Dorn, Gerald W. II, O'Rourke, Brian, Kitsis, Richard N

“…The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in…”
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DJ-1 protects the heart against ischemia–reperfusion injury by regulating mitochondrial fission by Shimizu, Yuuki, Lambert, Jonathan P, Nicholson, Chad K, Kim, Joshua J, Wolfson, David W, Cho, Hee Cheol, Husain, Ahsan, Naqvi, Nawazish, Chin, Li-Shen, Li, Lian, Calvert, John W

“…Abstract Recent data indicates that DJ-1 plays a role in the cellular response to stress. Here, we aimed to examine the underlying molecular mechanisms…”
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Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling by CALVERT, John W, GUNDEWAR, Susheel, JHA, Saurabh, GREER, James J. M, BESTERMANN, William H, TIAN, Rong, LEFER, David J

“…Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling John W. Calvert 1 , Susheel Gundewar 1 ,…”
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Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis by Polhemus, David, Kondo, Kazuhisa, Bhushan, Shashi, Bir, Shyamal C, Kevil, Christopher G, Murohara, Toyoaki, Lefer, David J, Calvert, John W

“…Hydrogen sulfide (H2S) has been shown to induce angiogenesis in in vitro models and to promote vessel growth in the setting of hindlimb ischemia. The goal of…”
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Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury by Bryan, Nathan S, Calvert, John W, Elrod, John W, Gundewar, Susheel, Ji, Sang Yong, Lefer, David J

“…Nitrite has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of nitrite are…”
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Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β3-Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols by Calvert, John W, Condit, Marah E, Aragón, Juan Pablo, Nicholson, Chad K, Moody, Bridgette F, Hood, Rebecca L, Sindler, Amy L, Gundewar, Susheel, Seals, Douglas R, Barouch, Lili A, Lefer, David J

“…RATIONALE:Exercise training confers sustainable protection against ischemia–reperfusion injury in animal models and has been associated with improved survival…”
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DJ-1 attenuates the glycation of mitochondrial complex I and complex III in the post-ischemic heart by Pantner, Yvanna, Polavarapu, Rohini, Chin, Lih-Shen, Li, Lian, Shimizu, Yuuki, Calvert, John W.

“…DJ-1 is a ubiquitously expressed protein that protects cells from stress through its conversion into an active protease. Recent work found that the active form…”
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Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer by Shiva, Sruti, Sack, Michael N, Greer, James J, Duranski, Mark, Ringwood, Lorna A, Burwell, Lindsay, Wang, Xunde, MacArthur, Peter H, Shoja, Amir, Raghavachari, Nalini, Calvert, John W, Brookes, Paul S, Lefer, David J, Gladwin, Mark T

“…Nitrite (NO(2)(-)) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the…”
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Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury by Grisanti, Laurel A, Gumpert, Anna M, Traynham, Christopher J, Gorsky, Joshua E, Repas, Ashley A, Gao, Erhe, Carter, Rhonda L, Yu, Daohai, Calvert, John W, García, Andrés Pun, Ibáñez, Borja, Rabinowitz, Joseph E, Koch, Walter J, Tilley, Douglas G

“…BACKGROUND:Immune cell–mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous…”
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