Differences in Neisseria gonorrhoeae population structure and antimicrobial resistance pattern between men who have sex with men and heterosexuals

Differences in Neisseria gonorrhoeae population structure and antimicrobial resistance pattern between men who have sex with men and heterosexuals

This study compared the antimicrobial susceptibility and genotypes of strains of Neisseria gonorrhoeae isolated from men who have sex with men (MSM) and from heterosexuals. One hundred and eleven strains were characterized from 107 patients, comprising 57 strains from 54 heterosexuals and 54 strains...

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Bibliographic Details
Published in:Epidemiology and infection Vol. 145; no. 2; pp. 379 - 385
Main Authors: SERRA-PLADEVALL, J., BARBERÁ, M. J., CALLARISA, A. E., BARTOLOMÉ-COMAS, R., ANDREU, A.
Format: Journal Article
Language:English
Published: England Cambridge University Press 01-01-2017
Subjects:
Adolescent
Adult
Anti-Bacterial Agents - pharmacology
Antigens
Antimicrobial agents
Drug resistance
Drug Resistance, Bacterial
Genetic Variation
Genotype
Gonorrhea
Gonorrhea - epidemiology
Gonorrhea - microbiology
Heterosexuality
Humans
Infections
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
Neisseria gonorrhoeae
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - isolation & purification
Patients
Population
Sexual and Gender Minorities
Sexually transmitted diseases
STD
STIs
Young Adult
Spain
Neisseria gonorrhoeae
sexual networks
Antimicrobial resistance
population structure
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Summary:This study compared the antimicrobial susceptibility and genotypes of strains of Neisseria gonorrhoeae isolated from men who have sex with men (MSM) and from heterosexuals. One hundred and eleven strains were characterized from 107 patients, comprising 57 strains from 54 heterosexuals and 54 strains from 53 MSM. Antimicrobial resistance rates were higher in strains from heterosexual patients, with resistance to cefixime (𝑃 = 0·0159) and ciprofloxacin (𝑃 = 0·002) being significantly higher. Typing by N. gonorrhoeae multi-antigen sequence typing (NG-MAST) showed that the most prevalent sequence types (ST) and genogroups (G) respectively were ST2400, ST2992, and ST5793, and G1407, G2992, and G2400. A statistically significant association was observed for MSM and genogroups G2400 (𝑃 = 0·0005) and G2992 (𝑃 = 0·0488), and G1407 with heterosexuals (𝑃 = 0·0002). We conclude that in our region distinct populations of gonococci are circulating among subjects with different sexual practices, with their corresponding transmission patterns. Furthermore, the high prevalence of genotype G2400 in MSM, has not to our knowledge been previously described.
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ISSN:0950-2688
1469-4409
DOI:10.1017/S095026881600234X