Search Results - "CALIGIURI, M"

Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia by Park, I-K, Mundy-Bosse, B, Whitman, S P, Zhang, X, Warner, S L, Bearss, D J, Blum, W, Marcucci, G, Caligiuri, M A

“…In acute myeloid leukemia (AML), about 25–30% of patients harbor a constitutively active receptor tyrosine kinase (RTK) FLT3 encoded by a FLT3 allele harboring…”
Get full text

CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma by Chu, J, Deng, Y, Benson, D M, He, S, Hughes, T, Zhang, J, Peng, Y, Mao, H, Yi, L, Ghoshal, K, He, X, Devine, S M, Zhang, X, Caligiuri, M A, Hofmeister, C C, Yu, J

“…Multiple myeloma (MM) is an incurable hematological malignancy. Chimeric antigen receptor (CAR)-expressing T cells have been demonstrated successfully in the…”
Get full text

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring by Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., Bloomfield, C. D., Lander, E. S.

“…Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or…”
Get full text

A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes by Nicoletti, G, Caligiuri, M E, Cherubini, A, Morelli, M, Novellino, F, Arabia, G, Salsone, M, Quattrone, A

“…The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with…”
Get full text

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation by Tarighat, S S, Santhanam, R, Frankhouser, D, Radomska, H S, Lai, H, Anghelina, M, Wang, H, Huang, X, Alinari, L, Walker, A, Caligiuri, M A, Croce, C M, Li, L, Garzon, R, Li, C, Baiocchi, R A, Marcucci, G

“…Changes in the enzymatic activity of protein arginine methyltransferase (PRMT) 5 have been associated with cancer; however, the protein’s role in acute myeloid…”
Get full text

Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia by Chen, L, Mao, H, Zhang, J, Chu, J, Devine, S, Caligiuri, M A, Yu, J

Get full text

THE BIG FIVE PERSONALITY CHARACTERISTICS AS PREDICTORS OF EXPATRIATE'S DESIRE TO TERMINATE THE ASSIGNMENT AND SUPERVISOR-RATED PERFORMANCE by CALIGIURI, PAULA M.

“…Applying the evolutionary theory of personality, this study proposed and tested the hypotheses that each of the Big Five personality characteristics…”
Get full text

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia by Park, I-K, Blum, W, Baker, S D, Caligiuri, M A

Get full text

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia by Khalife, J, Radomska, H S, Santhanam, R, Huang, X, Neviani, P, Saultz, J, Wang, H, Wu, Y-Z, Alachkar, H, Anghelina, M, Dorrance, A, Curfman, J, Bloomfield, C D, Medeiros, B C, Perrotti, D, Lee, L J, Lee, R J, Caligiuri, M A, Pichiorri, F, Croce, C M, Garzon, R, Guzman, M L, Mendler, J H, Marcucci, G

“…High levels of microRNA-155 ( miR-155 ) are associated with poor outcome in acute myeloid leukemia (AML). In AML, miR-155 is regulated by NF-κB, the activity…”
Get full text

Identification of blood biomarkers for psychosis using convergent functional genomics by Kurian, S M, Le-Niculescu, H, Patel, S D, Bertram, D, Davis, J, Dike, C, Yehyawi, N, Lysaker, P, Dustin, J, Caligiuri, M, Lohr, J, Lahiri, D K, Nurnberger, J I, Faraone, S V, Geyer, M A, Tsuang, M T, Schork, N J, Salomon, D R, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for psychotic disease states. We provide proof of principle for a convergent functional genomics…”
Get full text

Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia by Dorrance, A M, Neviani, P, Ferenchak, G J, Huang, X, Nicolet, D, Maharry, K S, Ozer, H G, Hoellarbauer, P, Khalife, J, Hill, E B, Yadav, M, Bolon, B N, Lee, R J, Lee, L J, Croce, C M, Garzon, R, Caligiuri, M A, Bloomfield, C D, Marcucci, G

“…Current treatments for acute myeloid leukemia (AML) are designed to target rapidly dividing blast populations with limited success in eradicating the…”
Get full text

Somatic mutational landscape of AML with inv(16) or t(8;21) identifies patterns of clonal evolution in relapse leukemia by Sood, R, Hansen, N F, Donovan, F X, Carrington, B, Bucci, D, Maskeri, B, Young, A, Trivedi, N S, Kohlschmidt, J, Stone, R M, Caligiuri, M A, Chandrasekharappa, S C, Marcucci, G, Mullikin, J C, Bloomfield, C D, Liu, P

Get full text

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study by WHITMAN, Susan P, ARCHER, Kellie J, KOLITZ, Jonathan E, LARSON, Richard A, BLOOMFIELD, Clara D, CALIGIURI, Michael A, LAN FENG, BALDUS, Claudia, BECKNELL, Brian, CARLSON, Brian D, CARROLL, Andrew J, MROZEK, Krzysztof, VARDIMAN, James W, GEORGE, Stephen L

“…The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age…”
Get full text

A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia by Metzeler, K H, Maharry, K, Kohlschmidt, J, Volinia, S, Mrózek, K, Becker, H, Nicolet, D, Whitman, S P, Mendler, J H, Schwind, S, Eisfeld, A-K, Wu, Y-Z, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Baer, M R, Carroll, A J, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D

“…Acute myeloid leukemia (AML) is hypothesized to be sustained by self-renewing leukemia stem cells (LSCs). Recently, gene expression signatures (GES) from…”
Get full text

3-T magnetic resonance imaging simultaneous automated multimodal approach improves detection of ambiguous visual hippocampal sclerosis by Vasta, R., Caligiuri, M. E., Labate, A., Cherubini, A., Mumoli, L., Ferlazzo, E., Perrotta, P., Lanza, P. L., Augimeri, A., Aguglia, U., Quattrone, A., Gambardella, A.

“…Background and purpose To evaluate if an automatic magnetic resonance imaging (MRI) processing system may improve detection of hippocampal sclerosis (Hs) in…”
Get full text

Motor and cognitive aspects of motor retardation in depression by Caligiuri, Michael P., Ellwanger, Joel

“…Background: Motor retardation is a common feature of major depressive disorder having potential prognostic and etiopathological significance. According to…”
Get full text

Testing a Theoretical Model for Examining the Relationship Between Family Adjustment and Expatriates' Work Adjustment by Caligiuri, Paula M, Hyland, MaryAnne M, Joshi, Aparna, Bross, Allon S

“…Based on theoretical perspectives from the work/family literature, this study tested a model for examining expatriate families' adjustment while on global…”
Get full text

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy by Whitman, S P, Kohlschmidt, J, Maharry, K, Volinia, S, Mrózek, K, Nicolet, D, Schwind, S, Becker, H, Metzeler, K H, Mendler, J H, Eisfeld, A-K, Carroll, A J, Powell, B L, Carter, T H, Baer, M R, Kolitz, J E, Park, I-K, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D

“…Emerging data demonstrate important roles for the TYRO3/AXL/MERTK receptor tyrosine kinase (TAM RTK) family in diverse cancers. We investigated the prognostic…”
Get full text

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells by MROZEK, E, ANDERSON, P, CALIGIURI, M. A

“…Human natural killer (NK) cells are bone marrow (BM)-derived CD2+CD16+CD56+ large granular lymphocytes (LGL) that lack CD3 yet contain the T-cell receptor…”
Get full text

Escalation of daunorubicin and addition of etoposide in the ADE regimen in acute myeloid leukemia patients aged 60 years and older: Cancer and Leukemia Group B Study 9720 by Baer, M R, George, S L, Sanford, B L, Mrózek, K, Kolitz, J E, Moore, J O, Stone, R M, Powell, B L, Caligiuri, M A, Bloomfield, C D, Larson, R A

“…Untreated de novo ( n =421) and secondary ( n =189) acute myeloid leukemia (AML) patients ⩾60 years received intensified chemotherapy, including daunorubicin…”
Get full text