Search Results - "CALE, Evan M"

Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings by Boswell, Kristin L, Watkins, Timothy A, Cale, Evan M, Samsel, Jakob, Andrews, Sarah F, Ambrozak, David R, Driscoll, Jefferson I, Messina, Michael A, Narpala, Sandeep, Hopp, Christine S, Cagigi, Alberto, Casazza, Joseph P, Yamamoto, Takuya, Zhou, Tongqing, Schief, William R, Crompton, Peter D, Ledgerwood, Julie E, Connors, Mark, Gama, Lucio, Kwong, Peter D, McDermott, Adrian, Mascola, John R, Koup, Richard A

“…The isolation and characterization of neutralizing antibodies from infection and vaccine settings informs future vaccine design, and methodologies that…”
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A diverse collection of B cells responded to HIV infection in infant BG505 by Simonich, Cassandra, Shipley, Mackenzie M., Doepker, Laura, Gobillot, Theodore, Garrett, Meghan, Cale, Evan M., Hennessy, Brianna, Itell, Hannah, Chohan, Vrasha, Doria-Rose, Nicole, Nduati, Ruth, Overbaugh, Julie

“…Increasing evidence suggests infants develop unique neutralizing antibody (nAb) responses to HIV compared to adults. Here, we dissected the nAb response of an…”
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Epitope-Specific CD8+ T Lymphocytes Cross-Recognize Mutant Simian Immunodeficiency Virus (SIV) Sequences but Fail To Contain Very Early Evolution and Eventual Fixation of Epitope Escape Mutations during SIV Infection by CALE, Evan M, HRABER, Peter, KORBER, Bette, LETVIN, Norman L, GIORGI, Elena E, FISCHER, Will, BHATTACHARYA, Tanmoy, LEITNER, Thomas, YEH, Wendy W, GLEASNER, Cheryl, GREEN, Lance D, HAN, Cliff S

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Direct Binding of Hepatitis C Virus Core to gC1qR on CD4+ and CD8+ T Cells Leads to Impaired Activation of Lck and Akt by Yao, Zhi Qiang, Eisen-Vandervelde, Audrey, Waggoner, Stephen N, Cale, Evan M, Hahn, Young S

“…Erratum ( vol. 81 , p. 3673 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Hepatitis C Virus Core Selectively Suppresses Interleukin-12 Synthesis in Human Macrophages by Interfering with AP-1 Activation by Eisen-Vandervelde, Audrey L, Waggoner, Stephen N, Yao, Zhi Qiang, Cale, Evan M, Hahn, Chang S, Hahn, Young S

“…Hepatitis C virus (HCV) is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading…”
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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants by Wang, Lingshu, Zhou, Tongqing, Zhang, Yi, Yang, Eun Sung, Schramm, Chaim A, Shi, Wei, Pegu, Amarendra, Oloniniyi, Olamide K, Henry, Amy R, Darko, Samuel, Narpala, Sandeep R, Hatcher, Christian, Martinez, David R, Tsybovsky, Yaroslav, Phung, Emily, Abiona, Olubukola M, Antia, Avan, Cale, Evan M, Chang, Lauren A, Choe, Misook, Corbett, Kizzmekia S, Davis, Rachel L, DiPiazza, Anthony T, Gordon, Ingelise J, Hait, Sabrina Helmold, Hermanus, Tandile, Kgagudi, Prudence, Laboune, Farida, Leung, Kwanyee, Liu, Tracy, Mason, Rosemarie D, Nazzari, Alexandra F, Novik, Laura, O'Connell, Sarah, O'Dell, Sijy, Olia, Adam S, Schmidt, Stephen D, Stephens, Tyler, Stringham, Christopher D, Talana, Chloe Adrienna, Teng, I-Ting, Wagner, Danielle A, Widge, Alicia T, Zhang, Baoshan, Roederer, Mario, Ledgerwood, Julie E, Ruckwardt, Tracy J, Gaudinski, Martin R, Moore, Penny L, Doria-Rose, Nicole A, Baric, Ralph S, Graham, Barney S, McDermott, Adrian B, Douek, Daniel C, Kwong, Peter D, Mascola, John R, Sullivan, Nancy J, Misasi, John

“…The emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) that are resistant to therapeutic antibodies highlights the need for continuing…”
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Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody by Kong, Rui, Xu, Kai, Zhou, Tongqing, Acharya, Priyamvada, Lemmin, Thomas, Liu, Kevin, Ozorowski, Gabriel, Soto, Cinque, Taft, Justin D., Bailer, Robert T., Cale, Evan M., Chen, Lei, Choi, Chang W., Chuang, Gwo-Yu, Doria-Rose, Nicole A., Druz, Aliaksandr, Georgiev, Ivelin S., Gorman, Jason, Huang, Jinghe, Joyce, M. Gordon, Louder, Mark K., Ma, Xiaochu, McKee, Krisha, O'Dell, Sijy, Pancera, Marie, Yang, Yongping, Blanchard, Scott C., Mothes, Walther, Burton, Dennis R., Koff, Wayne C., Connors, Mark, Ward, Andrew B., Kwong, Peter D., Mascola, John R.

“…The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the Env-gp41 subunit, is a critical component of the virus-cell entry…”
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New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency by Doria-Rose, Nicole A, Bhiman, Jinal N, Roark, Ryan S, Schramm, Chaim A, Gorman, Jason, Chuang, Gwo-Yu, Pancera, Marie, Cale, Evan M, Ernandes, Michael J, Louder, Mark K, Asokan, Mangaiarkarasi, Bailer, Robert T, Druz, Aliaksandr, Fraschilla, Isabella R, Garrett, Nigel J, Jarosinski, Marissa, Lynch, Rebecca M, McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Schmidt, Stephen D, Staupe, Ryan P, Sutton, Matthew S, Wang, Keyun, Wibmer, Constantinos Kurt, Haynes, Barton F, Abdool-Karim, Salim, Shapiro, Lawrence, Kwong, Peter D, Moore, Penny L, Morris, Lynn, Mascola, John R

“…The epitopes defined by HIV-1 broadly neutralizing antibodies (bNAbs) are valuable templates for vaccine design, and studies of the immunological development…”
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Compensatory Substitutions Restore Normal Core Assembly in Simian Immunodeficiency Virus Isolates with Gag Epitope Cytotoxic T-Lymphocyte Escape Mutations by YEH, Wendy W, CALE, Evan M, JARU-AMPORNPAN, Pimkwan, LORD, Carol I, PEYERL, Fred W, LETVIN, Norman L

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Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual by Krebs, Shelly J., Kwon, Young D., Schramm, Chaim A., Law, William H., Donofrio, Gina, Zhou, Kenneth H., Gift, Syna, Dussupt, Vincent, Georgiev, Ivelin S., Schätzle, Sebastian, McDaniel, Jonathan R., Lai, Yen-Ting, Sastry, Mallika, Zhang, Baoshan, Jarosinski, Marissa C., Ransier, Amy, Chenine, Agnes L., Asokan, Mangaiarkarasi, Bailer, Robert T., Bose, Meera, Cagigi, Alberto, Cale, Evan M., Chuang, Gwo-Yu, Darko, Samuel, Driscoll, Jefferson I., Druz, Aliaksandr, Gorman, Jason, Laboune, Farida, Louder, Mark K., McKee, Krisha, Mendez, Letzibeth, Moody, M. Anthony, O’Sullivan, Anne Marie, Owen, Christopher, Peng, Dongjun, Rawi, Reda, Sanders-Buell, Eric, Shen, Chen-Hsiang, Shiakolas, Andrea R., Stephens, Tyler, Tsybovsky, Yaroslav, Tucker, Courtney, Verardi, Raffaello, Wang, Keyun, Zhou, Jing, Zhou, Tongqing, Georgiou, George, Alam, S. Munir, Haynes, Barton F., Rolland, Morgane, Matyas, Gary R., Polonis, Victoria R., McDermott, Adrian B., Douek, Daniel C., Shapiro, Lawrence, Tovanabutra, Sodsai, Michael, Nelson L., Mascola, John R., Robb, Merlin L., Kwong, Peter D., Doria-Rose, Nicole A.

“…Lineage-based vaccine design is an attractive approach for eliciting broadly neutralizing antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied…”
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Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2 by Cale, Evan M., Driscoll, Jefferson I., Lee, Myungjin, Gorman, Jason, Zhou, Tongqing, Lu, Maolin, Geng, Hui, Lai, Yen-Ting, Chuang, Gwo-Yu, Doria-Rose, Nicole A., Mothes, Walther, Kwong, Peter D., Mascola, John R.

“…The conformationally dynamic HIV-1 envelope trimer (Env) is the target of broadly neutralizing antibodies (bnAbs) that block viral entry. Single-molecule…”
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Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop by Cale, Evan M., Gorman, Jason, Radakovich, Nathan A., Crooks, Ema T., Osawa, Keiko, Tong, Tommy, Li, Jiaqi, Nagarajan, Raju, Ozorowski, Gabriel, Ambrozak, David R., Asokan, Mangai, Bailer, Robert T., Bennici, Anthony K., Chen, Xuejun, Doria-Rose, Nicole A., Druz, Aliaksandr, Feng, Yu, Joyce, M. Gordon, Louder, Mark K., O’Dell, Sijy, Oliver, Courtney, Pancera, Marie, Connors, Mark, Hope, Thomas J., Kepler, Thomas B., Wyatt, Richard T., Ward, Andrew B., Georgiev, Ivelin S., Kwong, Peter D., Mascola, John R., Binley, James M.

“…Most HIV-1-specific neutralizing antibodies isolated to date exhibit unusual characteristics that complicate their elicitation. Neutralizing antibodies that…”
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Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound by Cale, Evan M, Bai, Hongjun, Bose, Meera, Messina, Michael A, Colby, Donn J, Sanders-Buell, Eric, Dearlove, Bethany, Li, Yifan, Engeman, Emily, Silas, Daniel, O'Sullivan, Anne Marie, Mann, Brendan, Pinyakorn, Suteeraporn, Intasan, Jintana, Benjapornpong, Khunthalee, Sacdalan, Carlo, Kroon, Eugène, Phanuphak, Nittaya, Gramzinski, Robert, Vasan, Sandhya, Robb, Merlin L, Michael, Nelson L, Lynch, Rebecca M, Bailer, Robert T, Pagliuzza, Amélie, Chomont, Nicolas, Pegu, Amarendra, Doria-Rose, Nicole A, Trautmann, Lydie, Crowell, Trevor A, Mascola, John R, Ananworanich, Jintanat, Tovanabutra, Sodsai, Rolland, Morgane

“…Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions…”
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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide by Alam, S Munir, Aussedat, Baptiste, Vohra, Yusuf, Meyerhoff, R Ryan, Cale, Evan M, Walkowicz, William E, Radakovich, Nathan A, Anasti, Kara, Armand, Lawrence, Parks, Robert, Sutherland, Laura, Scearce, Richard, Joyce, M Gordon, Pancera, Marie, Druz, Aliaksandr, Georgiev, Ivelin S, Von Holle, Tarra, Eaton, Amanda, Fox, Christopher, Reed, Steven G, Louder, Mark, Bailer, Robert T, Morris, Lynn, Abdool-Karim, Salim S, Cohen, Myron, Liao, Hua-Xin, Montefiori, David C, Park, Peter K, Fernández-Tejada, Alberto, Wiehe, Kevin, Santra, Sampa, Kepler, Thomas B, Saunders, Kevin O, Sodroski, Joseph, Kwong, Peter D, Mascola, John R, Bonsignori, Mattia, Moody, M Anthony, Danishefsky, Samuel, Haynes, Barton F

“…A goal for an HIV-1 vaccine is to overcome virus variability by inducing broadly neutralizing antibodies (bnAbs). One key target of bnAbs is the…”
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Vaccine-induced CD8+ T lymphocytes of rhesus monkeys recognize variant forms of an HIV epitope but do not mediate optimal functional activity by Hulot, Sandrine L, Cale, Evan M, Korber, Bette T, Letvin, Norman L

“…The sequence diversity of HIV-1 presents a challenge for the development of an effective HIV-1 vaccine, because such a vaccine must confer protection against…”
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Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding by Cale, Evan M, Bazick, Heidi S, Rianprakaisang, Tony A, Alam, S Munir, Letvin, Norman L

“…Viruses like HIV and SIV escape from containment by CD8(+) T lymphocytes through generating mutations that interfere with epitope peptide:MHC class I binding…”
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Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial by Casazza, Joseph P., Cale, Evan M., Narpala, Sandeep, Yamshchikov, Galina V., Coates, Emily E., Hendel, Cynthia S., Novik, Laura, Holman, LaSonji A., Widge, Alicia T., Apte, Preeti, Gordon, Ingelise, Gaudinski, Martin R., Conan-Cibotti, Michelle, Lin, Bob C., Nason, Martha C., Trofymenko, Olga, Telscher, Shinyi, Plummer, Sarah H., Wycuff, Diane, Adams, William C., Pandey, Janardan P., McDermott, Adrian, Roederer, Mario, Sukienik, Avery N., O’Dell, Sijy, Gall, Jason G., Flach, Britta, Terry, Travis L., Choe, Misook, Shi, Wei, Chen, Xuejun, Kaltovich, Florence, Saunders, Kevin O., Stein, Judy A., Doria-Rose, Nicole A., Schwartz, Richard M., Balazs, Alejandro B., Baltimore, David, Nabel, Gary J., Koup, Richard A., Graham, Barney S., Ledgerwood, Julie E., Mascola, John R.

“…Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-HIV antibodies (bnAbs) offers an alternative to attempting to…”
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Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound by Cale, Evan M, Bai, Hongjun, Bose, Meera, Messina, Michael A, Colby, Donn J, Sanders-Buell, Eric, Dearlove, Bethany, Li, Yifan, Engeman, Emily, Silas, Daniel, O'Sullivan, Anne Marie, Mann, Brendan, Pinyakorn, Suteeraporn, Intasan, Jintana, Benjapornpong, Khunthalee, Sacdalan, Carlo, Kroon, Eugene, Phanuphak, Nittaya, Gramzinski, Robert, Vasan, Sandhya, Robb, Merlin L, Michael, Nelson L, Lynch, Rebecca M, Bailer, Robert T, Pagliuzza, Amelie, Chomont, Nicolas, Pegu, Amarendra, Doria-Rose, Nicole A, Trautmann, Lydie, Crowell, Trevor A, Mascola, John R, Ananworanich, Jintanat, Tovanabutra, Sodsai, Rolland, Morgane

“…Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions…”
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Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop by Cale, Evan M., Gorman, Jason, Radakovich, Nathan A., Crooks, Ema T., Osawa, Keiko, Tong, Tommy, Li, Jiaqi, Nagarajan, Raju, Ozorowski, Gabriel, Ambrozak, David R., Asokan, Mangai, Bailer, Robert T., Bennici, Anthony K., Chen, Xuejun, Doria-Rose, Nicole A., Druz, Aliaksandr, Feng, Yu, Joyce, M. Gordon, Louder, Mark K., O’Dell, Sijy, Oliver, Courtney, Pancera, Marie, Connors, Mark, Hope, Thomas J., Kepler, Thomas B., Wyatt, Richard T., Ward, Andrew B., Georgiev, Ivelin S., Kwong, Peter D., Mascola, John R., Binley, James M.

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Mutations in a dominant Nef epitope of SIVmac diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding1 by Cale, Evan M., Bazick, Heidi S., Rianprakaisang, Tony A., Alam, S. Munir, Letvin, Norman L.

“…Viruses like HIV and SIV escape from containment by CD8 + T lymphocytes through generating mutations that interfere with epitope peptide:MHC class I binding…”
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