Search Results - "CALDERONE, V"

Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs by Testai, L., Rapposelli, S., Martelli, A., Breschi, M.C., Calderone, V.

“…Brief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This…”
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Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies by Martelli, A., d’Emmanuele di Villa Bianca, R., Cirino, G., Sorrentino, R., Calderone, V., Bucci, M.

“…Hydrogen sulfide (H2S) has been extensively studied as a signal molecule in the body for the past 30 years. Researchers have conducted studies using both…”
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Large-conductance, ca(2+)-activated k(+) channels: function, pharmacology and drugs by Calderone, V

“…Because of the physiological role played by the hyperpolarisation process resulting from a K(+) outflow, it is not surprising that compounds able to activate…”
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Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia/reperfusion injury by Testai, L., Montanaro, R., Flori, L., Pagnotta, E., Vellecco, V., Gorica, E., Ugolini, L., Righetti, L., Brancaleone, V., Bucci, M., Piragine, E., Martelli, A., Di Cesare Mannelli, L., Ghelardini, C., Calderone, V.

“…[Display omitted] Hydrogen sulfide (H2S) is a gasotransmitter deeply involved in cardiovascular homeostasis and implicated in the myocardial protection against…”
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De Novo Design of Nanostructured Iron-Cobalt Fischer-Tropsch Catalysts by Calderone, V. Roberto, Shiju, N. Raveendran, Curulla-Ferré, Daniel, Chambrey, Stéphane, Khodakov, Andrei, Rose, Amadeus, Thiessen, Johannes, Jess, Andreas, Rothenberg, Gadi

“…Audio cassettes hold the key to enhancing Fischer–Tropsch catalysis. Catalysts based on ultra‐thin cobalt shells surrounding cheap iron oxide cores (see…”
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Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels by Martelli, A., Testai, L., Breschi, M.C., Lawson, K., McKay, N.G., Miceli, F., Taglialatela, M., Calderone, V.

“…Hydrogen sulphide (H2S) has been recently hypothesized to be an endogenous adipocyte-derived relaxing factor, evoking vasorelaxation of conductance and…”
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The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury by Testai, L., Martelli, A., Marino, A., D’Antongiovanni, V., Ciregia, F., Giusti, L., Lucacchini, A., Chericoni, S., Breschi, M.C., Calderone, V.

“…Naringenin (NAR), flavonoid abundant in the genus Citrus, has been reported to interact with the large-conductance calcium-activated potassium channels (BK)…”
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Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin by Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E

“…The inhibition of a subgroup of human serine/threonine protein phosphatases is responsible for the cytotoxicity of cantharidin and norcantharidin against tumor…”
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When molecular replacement has no trivial solution: The importance of model editing in human S100Z X-ray structure solution by Calderone, V., Fragai, M., Luchinat, C.

“…Overall view of the asymmetric unit containing the two physiological homodimers of human apo-S100Z. [Display omitted] •Molecular replacement is the most used…”
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Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds by Calderone, V., Fragai, M., Gallo, G., Luchinat, C.

“…The X-ray structure of human apo-S100Z has been solved and compared with that of the zebrafish calcium-bound S100Z, which is the closest in sequence. Human…”
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Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectives by Martelli, A, Testai, L, Marino, A, Breschi, M C, Da Settimo, F, Calderone, V

“…Hydrogen sulphide (H(2)S) is now viewed as an important endogenous gasotransmitter, which exhibits many beneficial effects on the cardiovascular system. H(2)S…”
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(+/−)‐Naringenin as large conductance Ca2+‐activated K+ (BKCa) channel opener in vascular smooth muscle cells by Saponara, S, Testai, L, Iozzi, D, Martinotti, E, Martelli, A, Chericoni, S, Sgaragli, G, Fusi, F, Calderone, V

“…Background and purpose. The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical and electrophysiological effects of…”
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(+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells by Saponara, S, Testai, L, Iozzi, D, Martinotti, E, Martelli, A, Chericoni, S, Sgaragli, G, Fusi, F, Calderone, V

“…BACKGROUND AND PURPOSE. The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical and electrophysiological effects of…”
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Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions by Testai, L., D'Antongiovanni, V., Piano, I., Martelli, A., Citi, V., Duranti, E., Virdis, A., Blandizzi, C., Gargini, C., Breschi, M.C., Calderone, V.

“…•Hypertensive coronary bed is hyporeactive to NO and H2S.•In normotension, H2S-induced coronary vasodilation obligatorily requires NO.•In normotension,…”
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Efficient alkyne homocoupling catalysed by copper immobilized on functionalized silica by van Gelderen, Laurens, Rothenberg, Gadi, Roberto Calderone, V., Wilson, Karen, Raveendran Shiju, N.

“…Copper immobilized on a functionalized silica support is a good catalyst for the homocoupling of terminal alkynes. The so‐called Glaser–Hay coupling reaction…”
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Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects by Kirby, R W, Martelli, A, Calderone, V, McKay, N G, Lawson, K

“…Large conductance calcium activated potassium channels (BKCa) are fundamental in the control of cellular excitability. Thus, compounds that activate BKCa…”
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The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction by Martelli, A., Testai, L., Anzini, M., Cappelli, A., Di Capua, A., Biava, M., Poce, G., Consalvi, S., Giordani, A., Caselli, G., Rovati, L., Ghelardini, C., Patrignani, P., Sautebin, L., Breschi, M.C., Calderone, V.

“…Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared…”
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NO-releasing hybrids of cardiovascular drugs by Martelli, A, Rapposelli, S, Calderone, V

“…Nitric oxide (NO) is an endogenous compound, which plays a fundamental role in the modulation of the function of the cardiovascular system, where it induces…”
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Large conductance Ca2+-activated K+ channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects by Kirby, R.W., Martelli, A., Calderone, V., McKay, N.G., Lawson, K.

“…Human Embryonic Kidney (HEK293) cells expressing human BKCa channel α-subunit (open symbol) alone or α+β1–subunit complex (filled symbol). Large conductance…”
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120 UNVEILING A NEW MECHANISM OF REGULATION OF ANGIOGENESIS IN PORTAL HYPERTENSION THROUGH TRANSLATIONAL CONTROL BY THE CPEB FAMILY OF PROTEINS by Gallego, J, Calderone, V, Garcia-Pras, E, Bosch, J, Mendez, R, Fernández, M

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