Search Results - "CALABRESE, David"

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex by Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S.

“…G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC , and regulate gene expression…”
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Evidence for ligandable sites in structured RNA throughout the Protein Data Bank by Hewitt, William M., Calabrese, David R., Schneekloth, John S.

“…[Display omitted] RNA has attracted considerable attention as a target for small molecules. However, methods to identify, study, and characterize suitable RNA…”
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Machine Learning Informs RNA‐Binding Chemical Space by Yazdani, Kamyar, Jordan, Deondre, Yang, Mo, Fullenkamp, Christopher R., Calabrese, David R., Boer, Robert, Hilimire, Thomas, Allen, Timothy E. H., Khan, Rabia T., Schneekloth, John S.

“…Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but compared to the protein targeting literature our understanding of…”
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Role of Backbone Chemistry and Monomer Sequence in Amphiphilic Oligopeptide- and Oligopeptoid-Functionalized PDMS- and PEO-Based Block Copolymers for Marine Antifouling and Fouling Release Coatings by Patterson, Anastasia L, Wenning, Brandon, Rizis, Georgios, Calabrese, David R, Finlay, John A, Franco, Sofia C, Zuckermann, Ronald N, Clare, Anthony S, Kramer, Edward J, Ober, Christopher K, Segalman, Rachel A

“…Poly­(dimethylsiloxane) (PDMS)- and poly­(ethylene oxide) (PEO)-based block copolymer coatings functionalized with amphiphilic, surface-active, and…”
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Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene by Yang, Mo, Carter, Sakereh, Parmar, Shaifaly, Bume, Desta D, Calabrese, David R, Liang, Xiao, Yazdani, Kamyar, Xu, Man, Liu, Zhihui, Thiele, Carol J, Schneekloth, John S

“…Abstract The MYCN gene encodes the transcription factor N-Myc, a driver of neuroblastoma (NB). Targeting G-quadruplexes (G4s) with small molecules is…”
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Investigating the NRAS 5' UTR as a target for small molecules by Balaratnam, Sumirtha, Torrey, Zachary R, Calabrese, David R, Banco, Michael T, Yazdani, Kamyar, Liang, Xiao, Fullenkamp, Christopher R, Seshadri, Srinath, Holewinski, Ronald J, Andresson, Thorkell, Ferré-D'Amaré, Adrian R, Incarnato, Danny, Schneekloth, Jr, John S

“…Neuroblastoma RAS (NRAS) is an oncogene that is deregulated and highly mutated in cancers including melanomas and acute myeloid leukemias. The 5' untranslated…”
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Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression by Felsenstein, Kenneth M., Saunders, Lindsey B., Simmons, John K., Leon, Elena, Calabrese, David R., Zhang, Shuling, Michalowski, Aleksandra, Gareiss, Peter, Mock, Beverly A., Schneekloth, John S.

“…The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small…”
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Ligand-observed NMR techniques to probe RNA-small molecule interactions by Calabrese, David R, Connelly, Colleen M, Schneekloth, Jr, John S

“…A growing understanding of the structure and function of RNA has revealed it as a key regulator of gene expression and disease. A multitude of noncoding…”
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Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence by Ferrari, Sélène, Ischer, Françoise, Calabrese, David, Posteraro, Brunella, Sanguinetti, Maurizio, Fadda, Giovanni, Rohde, Bettina, Bauser, Christopher, Bader, Oliver, Sanglard, Dominique

“…CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are…”
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Characterization of clinically used oral antiseptics as quadruplex-binding ligands by Calabrese, David R, Zlotkowski, Katherine, Alden, Stephanie, Hewitt, William M, Connelly, Colleen M, Wilson, Robert M, Gaikwad, Snehal, Chen, Lu, Guha, Rajarshi, Thomas, Craig J, Mock, Beverly A, Schneekloth, John S

“…Abstract Approaches to characterize the nucleic acid-binding properties of drugs and druglike small molecules are crucial to understanding the behavior of…”
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A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma by Gaikwad, Snehal M., Phyo, Zaw, Arteaga, Anaisa Quintanilla, Gorjifard, Sayeh, Calabrese, David R., Connors, Daniel, Huang, Jing, Michalowski, Aleksandra M., Zhang, Shuling, Liu, Zheng-Gang, Schneekloth, John S., Mock, Beverly A.

“…New approaches to target MYC include the stabilization of a guanine-rich, G-quadruplex (G4) tertiary DNA structure in the NHE III region of its promoter…”
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Amphiphilic triblock copolymers with PEGylated hydrocarbon structures as environmentally friendly marine antifouling and fouling-release coatings by Zhou, Zhaoli, Calabrese, David R., Taylor, Warren, Finlay, John A., Callow, Maureen E., Callow, James A., Fischer, Daniel, Kramer, Edward J., Ober, Christopher K.

“…The ideal marine antifouling (AF)/fouling-release (FR) coating should be non-toxic, while effectively either resisting the attachment of marine organisms (AF)…”
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Amphiphilic oligopeptides grafted to PDMS-based diblock copolymers for use in antifouling and fouling release coatings by Calabrese, David R., Wenning, Brandon, Finlay, John A., Callow, Maureen E., Callow, James A., Fischer, Daniel, Ober, Christopher K.

“…Amphiphilic surfaces, having both hydrophobic and hydrophilic properties, have been considered for marine antifouling and fouling release applications, as they…”
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High-resolution acoustic ejection mass spectrometry for high-throughput library screening by Hoxie, Nate, Calabrese, David R., Itkin, Zina, Gomba, Glenn, Shen, Min, Verma, Meghav, Janiszewski, John S., Shrimp, Jonathan H., Wilson, Kelli M., Michael, Sam, Hall, Matthew D., Burton, Lyle, Covey, Tom, Liu, Chang

“…An approach is described for high-throughput quality assessment of drug candidate libraries using high-resolution acoustic ejection mass spectrometry (AEMS)…”
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The ENTPD1 promoter polymorphism −860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk by Maloney, James P., Branchford, Brian R., Brodsky, Gary L., Cosmic, Maxwell S., Calabrese, David W., Aquilante, Christina L., Maloney, Kelly W., Gonzalez, Joseph R., Zhang, Weiming, Moreau, Kerrie L., Wiggins, Kerri L., Smith, Nicholas L., Broeckel, Ulrich, Di Paola, Jorge

“…ABSTRACT Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) degrades the purines ATP and ADP that are key regulators of inflammation and clotting. We…”
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Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension by Maloney, James P, Stearman, Robert S, Bull, Todd M, Calabrese, David W, Tripp-Addison, Megan L, Wick, Marilee J, Broeckel, Ulrich, Robbins, Ivan M, Wheeler, Lisa A, Cogan, Joy D, Loyd, James E

“…Most patients with familial pulmonary arterial hypertension (FPAH) carry mutations in the bone morphogenic protein receptor 2 gene (BMPR2). Yet carriers have…”
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Machine Learning Informs RNA‐Binding Chemical Space by Yazdani, Kamyar, Jordan, Deondre, Yang, Mo, Fullenkamp, Christopher R., Calabrese, David R., Boer, Robert, Hilimire, Thomas, Allen, Timothy E. H., Khan, Rabia T., Schneekloth, John S.

“…Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but compared to the protein targeting literature our understanding of…”
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Design, Synthesis, and Use of Y‑Shaped ATRP/NMP Surface Tethered Initiator by Calabrese, David R, Ditter, David, Liedel, Clemens, Blumfield, Amit, Zentel, Rudolf, Ober, Christopher K

“…Heterogeneous polymer brushes on surfaces can be easily formed from a binary initiator on a silicon oxide substrate where two different types of polymers can…”
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Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients by PEREA, Sofia, LOPEZ-RIBOT, José L, KIRKPATRICK, William R, MCATEE, Robert K, SANTILLAN, Rebecca A, MARTINEZ, Marcos, CALABRESE, David, SANGLARD, Dominique, PATTERSON, Thomas F

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Evolution of Drug Resistance in Experimental Populations of Candida albicans by Cowen, L E, Sanglard, D, Calabrese, D, Sirjusingh, C, Anderson, J B, Kohn, L M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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