Search Results - "CAKSA, SIGNE"

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma by Capparelli, Claudia, Purwin, Timothy J., Glasheen, McKenna, Caksa, Signe, Tiago, Manoela, Wilski, Nicole, Pomante, Danielle, Rosenbaum, Sheera, Nguyen, Mai Q., Cai, Weijia, Franco-Barraza, Janusz, Zheng, Richard, Kumar, Gaurav, Chervoneva, Inna, Shimada, Ayako, Rebecca, Vito W., Snook, Adam E., Hookim, Kim, Xu, Xiaowei, Cukierman, Edna, Herlyn, Meenhard, Aplin, Andrew E.

“…Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which enable adaptation to metastatic microenvironments and resistance…”
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Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas by Purwin, Timothy J., Caksa, Signe, Sacan, Ahmet, Capparelli, Claudia, Aplin, Andrew E.

“…Evidence is mounting for cross-resistance between immune checkpoint and targeted kinase inhibitor therapies in cutaneous melanoma patients. Since the loss of…”
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Total Calcium Intake Is Associated With Trabecular Bone Density in Adolescent Girls With Type 1 Diabetes by Saunders, Rylee K, Kilroe, Kathleen M, Joseph, Taïsha V., Caksa, Signe, Bouxsein, Mary L, Misra, Madhusmita, Mitchell, Deborah M

“…ABSTRACT Type 1 diabetes (T1D) confers an increased risk of fracture and is associated with lower bone mineral density (BMD) and altered microarchitecture…”
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The future of targeted kinase inhibitors in melanoma by Caksa, Signe, Baqai, Usman, Aplin, Andrew E.

“…Melanoma is a cancer of the pigment-producing cells of the body and its incidence is rising. Targeted inhibitors that act against kinases in the MAPK pathway…”
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Elevated HbA1c Is Associated with Altered Cortical and Trabecular Microarchitecture in Girls with Type 1 Diabetes by Mitchell, Deborah M, Caksa, Signe, Joseph, Taïsha, Bouxsein, Mary L, Misra, Madhusmita

“…Abstract Context Skeletal fragility is a significant complication of type 1 diabetes (T1D), with an increased risk of fracture observed starting in childhood…”
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Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma by Glasheen, McKenna Q., Caksa, Signe, Young, Amelia G., Wilski, Nicole A., Ott, Connor A., Chervoneva, Inna, Flaherty, Keith T., Herlyn, Meenhard, Xu, Xiaowei, Aplin, Andrew E., Capparelli, Claudia

“…Drug tolerance and minimal residual disease (MRD) are likely to prelude acquired resistance to targeted therapy. Mechanisms that allow persister cells to…”
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Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes by Joseph, Taïsha V, Caksa, Signe, Misra, Madhusmita, Mitchell, Deborah M

“…Abstract Context Among patients with type 1 diabetes (T1D), the risk of hip fracture is up to 6-fold greater than that of the general population. However, the…”
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Female Athletes With Multiple Bone Stress Injuries (BSI) Display Restrictive Eating Behaviors: 398 by Gehman, Sarah, Garrahan, Margaret, Rudolph, Sara, Caksa, Signe, Tenforde, Adam S., Ackerman, Kathryn E., Bouxsein, Mary L., Popp, Kristin L.

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Female Athletes With Multiple Bone Stress Injuries (BSI) Display Restrictive Eating Behaviors: 398 by Gehman, Sarah, Garrahan, Margaret, Rudolph, Sara, Caksa, Signe, Tenforde, Adam S., Ackerman, Kathryn E., Bouxsein, Mary L., Popp, Kristin L.

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Cortical Bone Material Strength Index and Bone Microarchitecture in Postmenopausal Women With Atypical Femoral Fractures by Popp, Kristin L, Caksa, Signe, Martinez‐Betancourt, Adriana, Yuan, Amy, Tsai, Joy, Yu, Elaine W, Bouxsein, Mary L

“…ABSTRACT Atypical femoral fractures are rare fractures that occur in the subtrochanteric or diaphyseal region of the femur with minimal or no trauma. Though…”
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Bone mass, microarchitecture and strength are influenced by race/ethnicity in young adult men and women by Popp, Kristin L., Hughes, Julie M., Martinez-Betancourt, Adriana, Scott, Matthew, Turkington, Victoria, Caksa, Signe, Guerriere, Katelyn I., Ackerman, Kathryn E., Xu, Chun, Unnikrishnan, Ginu, Reifman, Jaques, Bouxsein, Mary L.

“…Lower rates of fracture in both Blacks compared to Whites, and men compared to women are not completely explained by differences in bone mineral density (BMD)…”
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Female Runners With Multiple Bone Stress Injuries Have Smaller Bone Area Compared To Healthy Runners: 315 Board #131 May 27 10:30 AM - 12:00 PM by Popp, Kristin L., Rudolph, Sara, Caksa, Signe, Hughes, Julie M., Tenforde, Adam S., Ackerman, Kathryn E., Bouxsein, Mary L.

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Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography by Caksa, Signe, Yuan, Amy, Rudolph, Sara E., Yu, Elaine W., Popp, Kristin L., Bouxsein, Mary L.

“…High-resolution peripheral quantitative computed tomography (HR-pQCT) is a non-invasive method of measuring volumetric bone mineral density (vBMD) and…”
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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects by Rosenbaum, Sheera R., Tiago, Manoela, Caksa, Signe, Capparelli, Claudia, Purwin, Timothy J., Kumar, Gaurav, Glasheen, McKenna, Pomante, Danielle, Kotas, Daniel, Chervoneva, Inna, Aplin, Andrew E.

“…Developmental factors may regulate the expression of immune modulatory proteins in cancer, linking embryonic development and cancer cell immune evasion. This…”
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Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma by Glasheen, McKenna Q, Caksa, Signe, Young, Amelia G, Wilski, Nicole A, Ott, Connor A, Chervoneva, Inna, Flaherty, Keith T, Herlyn, Meenhard, Xu, Xiaowei, Aplin, Andrew E, Capparelli, Claudia

“…Drug tolerance and minimal residual disease (MRD) are likely to prelude acquired resistance to targeted therapy. Mechanisms that allow persister cells to…”
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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries by Rudolph, Sara E., Caksa, Signe, Gehman, Sarah, Garrahan, Maggie, Hughes, Julie M., Tenforde, Adam S., Ackerman, Kathryn E., Bouxsein, Mary L., Popp, Kristin L.

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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries by RUDOLPH, SARA E., CAKSA, SIGNE, GEHMAN, SARAH, GARRAHAN, MARGARET, HUGHES, JULIE M., TENFORDE, ADAM S., ACKERMAN, KATHRYN E., BOUXSEIN, MARY L., POPP, KRISTIN L.

“…To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of…”
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Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures by Rozental, Tamara D, Walley, Kempland C, Demissie, Serkalem, Caksa, Signe, Martinez‐Betancourt, Adriana, Parker, Amber M, Tsai, Joy N, Yu, Elaine W, Bouxsein, Mary L

“…ABSTRACT We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent…”
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SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death by Rosenbaum, Sheera R, Caksa, Signe, Stefanski, Casey D, Trachtenberg, Isabella V, Wilson, Haley P, Wilski, Nicole A, Ott, Connor A, Purwin, Timothy J, Haj, Jelan I, Pomante, Danielle, Kotas, Daniel, Chervoneva, Inna, Capparelli, Claudia, Aplin, Andrew E

“…The transcription factor, SOX10, plays an important role in the differentiation of neural crest precursors to the melanocytic lineage. Malignant transformation…”
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Abstract 4409: Cholesterol pathway determines ovarian cancer drug resistance through transcription factor SREBP2 by Karashchuk, Galina, Karashchuk, Nataliya, Caksa, Signe, Smith, Tyler S., Brodsky, Alexander S.

“…Ovarian cancer is the most common cause of gynecological cancer death in women in United States. Up to 70% of all ovarian cancer cases are high-grade serous…”
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