Search Results - "CAILLIEREZ, Raphaëlle"

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease by Richetin, Kevin, Steullet, Pascal, Pachoud, Mathieu, Perbet, Romain, Parietti, Enea, Maheswaran, Mathischan, Eddarkaoui, Sabiha, Bégard, Séverine, Pythoud, Catherine, Rey, Maria, Caillierez, Raphaëlle, Q Do, Kim, Halliez, Sophie, Bezzi, Paola, Buée, Luc, Leuba, Geneviève, Colin, Morvane, Toni, Nicolas, Déglon, Nicole

“…Alzheimer’s disease (AD) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. However, the role of…”
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Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease by Faivre, Emilie, Coelho, Joana E., Zornbach, Katja, Malik, Enas, Baqi, Younis, Schneider, Marion, Cellai, Lucrezia, Carvalho, Kevin, Sebda, Shéhérazade, Figeac, Martin, Eddarkaoui, Sabiha, Caillierez, Raphaëlle, Chern, Yijuang, Heneka, Michael, Sergeant, Nicolas, Müller, Christa E., Halle, Annett, Buée, Luc, Lopes, Luisa V., Blum, David

“…Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer’s disease (AD) and mitigates both…”
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Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology by Belarbi, Karim, Burnouf, Sylvie, Fernandez-Gomez, Francisco-Jose, Laurent, Cyril, Lestavel, Sophie, Figeac, Martin, Sultan, Audrey, Troquier, Laetitia, Leboucher, Antoine, Caillierez, Raphaëlle, Grosjean, Marie-Eve, Demeyer, Dominique, Obriot, Hélène, Brion, Ingrid, Barbot, Bérangère, Galas, Marie-Christine, Staels, Bart, Humez, Sandrine, Sergeant, Nicolas, Schraen-Maschke, Susanna, Muhr-Tailleux, Anne, Hamdane, Malika, Buée, Luc, Blum, David

“…Abstract Tau pathology is encountered in many neurodegenerative disorders known as tauopathies, including Alzheimer's disease. Physical activity is a lifestyle…”
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Encephalopathy induced by Alzheimer brain inoculation in a non-human primate by Gary, Charlotte, Lam, Suzanne, Hérard, Anne-Sophie, Koch, James E, Petit, Fanny, Gipchtein, Pauline, Sawiak, Stephen J, Caillierez, Raphaëlle, Eddarkaoui, Sabiha, Colin, Morvane, Aujard, Fabienne, Deslys, Jean-Philippe, Brouillet, Emmanuel, Buée, Luc, Comoy, Emmanuel E, Pifferi, Fabien, Picq, Jean-Luc, Dhenain, Marc

“…Alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of…”
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Ectosomes: a new mechanism for non-exosomal secretion of tau protein by Dujardin, Simon, Bégard, Séverine, Caillierez, Raphaëlle, Lachaud, Cédrick, Delattre, Lucie, Carrier, Sébastien, Loyens, Anne, Galas, Marie-Christine, Bousset, Luc, Melki, Ronald, Aurégan, Gwennaëlle, Hantraye, Philippe, Brouillet, Emmanuel, Buée, Luc, Colin, Morvane

“…Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be…”
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Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody by Albert, Marie, Mairet-Coello, Georges, Danis, Clément, Lieger, Sarah, Caillierez, Raphaëlle, Carrier, Sébastien, Skrobala, Emilie, Landrieu, Isabelle, Michel, Anne, Schmitt, Mathieu, Citron, Martin, Downey, Patrick, Courade, Jean-Philippe, Buée, Luc, Colin, Morvane

“…Tauopathies are neurodegenerative diseases characterized by the intraneuronal accumulation of aggregated tau. The staging of this neurodegenerative process is…”
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Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy by Laurent, Cyril, Dorothée, Guillaume, Hunot, Stéphane, Martin, Elodie, Monnet, Yann, Duchamp, Marie, Dong, Yuan, Légeron, François-Pierre, Leboucher, Antoine, Burnouf, Sylvie, Faivre, Emilie, Carvalho, Kévin, Caillierez, Raphaëlle, Zommer, Nadège, Demeyer, Dominique, Jouy, Nathalie, Sazdovitch, Veronique, Schraen-Maschke, Susanna, Delarasse, Cécile, Buée, Luc, Blum, David

“…Alzheimer's disease is characterized by the combined presence of amyloid plaques and tau pathology, the latter being correlated with the progression of…”
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The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory by Marciniak, Elodie, Faivre, Emilie, Dutar, Patrick, Alves Pires, Claire, Demeyer, Dominique, Caillierez, Raphaëlle, Laloux, Charlotte, Buée, Luc, Blum, David, Humez, Sandrine

“…Chemokines are signaling molecules playing an important role in immune regulations. They are also thought to regulate brain development, neurogenesis and…”
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Tau Phosphorylation and Sevoflurane Anesthesia by Le Freche, Hélène, Brouillette, Jonathan, Fernandez-Gomez, Francisco-José, Patin, Pauline, Caillierez, Raphaëlle, Zommer, Nadège, Sergeant, Nicolas, Buée-Scherrer, Valérie, Lebuffe, Gilles, Blum, David, Buée, Luc

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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment by Danis, Clément, Dupré, Elian, Zejneli, Orgeta, Caillierez, Raphaëlle, Arrial, Alexis, Bégard, Séverine, Mortelecque, Justine, Eddarkaoui, Sabiha, Loyens, Anne, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Buée, Luc, Landrieu, Isabelle

“…Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of…”
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Impact of chronic doxycycline treatment in the APP/PS1 mouse model of Alzheimer's disease by Gomez-Murcia, Victoria, Carvalho, Kevin, Thiroux, Bryan, Caillierez, Raphaëlle, Besegher, Melanie, Sergeant, Nicolas, Buée, Luc, Faivre, Emile, Blum, David

“…Due to the pathophysiological complexity of Alzheimer's disease, multitarget approaches able to mitigate several pathogenic mechanisms are of interest…”
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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease by Sergeant, Nicolas, Vingtdeux, Valérie, Eddarkaoui, Sabiha, Gay, Marion, Evrard, Caroline, Le Fur, Nicolas, Laurent, Cyril, Caillierez, Raphaelle, Obriot, Hélène, Larchanché, Paul-Emmanuel, Farce, Amaury, Coevoet, Mathilde, Carato, Pascal, Kouach, Mostafa, Descat, Amandine, Dallemagne, Patrick, Buée-Scherrer, Valérie, Blum, David, Hamdane, Malika, Buée, Luc, Melnyk, Patricia

“…Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment…”
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Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies by Dujardin, Simon, Lécolle, Katia, Caillierez, Raphaëlle, Bégard, Séverine, Zommer, Nadège, Lachaud, Cédrick, Carrier, Sébastien, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Colin, Morvane, Buée, Luc

“…In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain,…”
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Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology by Burlot, Marie-Anne, Braudeau, Jérôme, Michaelsen-Preusse, Kristin, Potier, Brigitte, Ayciriex, Sophie, Varin, Jennifer, Gautier, Benoit, Djelti, Fathia, Audrain, Mickael, Dauphinot, Luce, Fernandez-Gomez, Francisco-Jose, Caillierez, Raphaëlle, Laprévote, Olivier, Bièche, Ivan, Auzeil, Nicolas, Potier, Marie-Claude, Dutar, Patrick, Korte, Martin, Buée, Luc, Blum, David, Cartier, Nathalie

“…Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid component and altered cholesterol metabolism are closely linked, but…”
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Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies by Leroux, Elodie, Perbet, Romain, Caillierez, Raphaëlle, Richetin, Kevin, Lieger, Sarah, Espourteille, Jeanne, Bouillet, Thomas, Bégard, Séverine, Danis, Clément, Loyens, Anne, Toni, Nicolas, Déglon, Nicole, Deramecourt, Vincent, Schraen-Maschke, Susanna, Buée, Luc, Colin, Morvane

“…Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. Seed-competent tau species have been suggested to spread from cell…”
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Different tau species lead to heterogeneous tau pathology propagation and misfolding by Dujardin, Simon, Bégard, Séverine, Caillierez, Raphaëlle, Lachaud, Cédrick, Carrier, Sébastien, Lieger, Sarah, Gonzalez, Jose A, Deramecourt, Vincent, Déglon, Nicole, Maurage, Claude-Alain, Frosch, Matthew P, Hyman, Bradley T, Colin, Morvane, Buée, Luc

“…Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on…”
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Tau Phosphorylation and Sevoflurane Anesthesia: An Association to Postoperative Cognitive Impairment by FRECHE, Hélène Le, BROUILLETTE, Jonathan, BUEE, Luc, FERNANDEZ-GOMEZ, Francisco-Jose, PATIN, Pauline, CAILLIEREZ, Raphaëlle, ZOMMER, Nadège, SERGEANT, Nicolas, BUEE-SCHERRER, Valérie, LEBUFFE, Gilles, BLUM, David

“…There is a growing interest in the involvement of anesthetic agents in the etiology of postoperative cognitive dysfunction. Recent animal studies suggest that…”
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Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy by Ahmed, Tariq, Van der Jeugd, Ann, Caillierez, Raphaëlle, Buée, Luc, Blum, David, D’Hooge, Rudi, Balschun, Detlef

“…A major goal in diseases is identifying a potential therapeutic agent that is cost-effective and can remedy some, if not all, disease symptoms. In AD,…”
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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice by Gomez-Murcia, Victoria, Launay, Agathe, Carvalho, Kévin, Burgard, Anaëlle, Meriaux, Céline, Caillierez, Raphaëlle, Eddarkaoui, Sabiha, Kilinc, Devrim, Siedlecki-Wullich, Dolores, Besegher, Mélanie, Bégard, Séverine, Thiroux, Bryan, Jung, Matthieu, Nebie, Ouada, Wisztorski, Maxence, Déglon, Nicole, Montmasson, Claire, Bemelmans, Alexis-Pierre, Hamdane, Malika, Lebouvier, Thibaud, Vieau, Didier, Fournier, Isabelle, Buee, Luc, Lévi, Sabine, Lopes, Luisa V, Boutillier, Anne-Laurence, Faivre, Emilie, Blum, David

“…Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of…”
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Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice by Leboucher, Antoine, Laurent, Cyril, Fernandez-Gomez, Francisco-José, Burnouf, Sylvie, Troquier, Laetitia, Eddarkaoui, Sabiha, Demeyer, Dominique, Caillierez, Raphaëlle, Zommer, Nadège, Vallez, Emmanuelle, Bantubungi, Kadiombo, Breton, Christophe, Pigny, Pascal, Buée-Scherrer, Valérie, Staels, Bart, Hamdane, Malika, Tailleux, Anne, Buée, Luc, Blum, David

“…The τ pathology found in Alzheimer disease (AD) is crucial in cognitive decline. Midlife development of obesity, a major risk factor of insulin resistance and…”
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