Search Results - "CAIAFA, PAOLA"

DNA methylation dynamics in aging: how far are we from understanding the mechanisms? by Ciccarone, Fabio, Tagliatesta, Stefano, Caiafa, Paola, Zampieri, Michele

“…•Aging trajectories can be closely tracked down by changes in the DNA epigenetic modification patterns•We summarise current knowledge about DNA…”
Get full text

Reconfiguration of DNA methylation in aging by Zampieri, Michele, Ciccarone, Fabio, Calabrese, Roberta, Franceschi, Claudio, Bürkle, Alexander, Caiafa, Paola

“…•Methylated cytosines have a non-random distribution throughout the genome.•DNA methylation patterns are dynamic states balanced by methylation and…”
Get full text

CTCF and its protein partners: divide and rule? by Zlatanova, Jordanka, Caiafa, Paola

“…CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to,…”
Get full text

Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns by Caiafa, Paola, Guastafierro, Tiziana, Zampieri, Michele

“…In the postgenome era, attention is being focused on those epigenetic modifications that modulate chromatin structure to guarantee that information present on…”
Get full text

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme by Ciccarone, Fabio, Valentini, Elisabetta, Zampieri, Michele, Caiafa, Paola

“…5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation…”
Get full text

Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription by Verdone, Loredana, La Fortezza, Marco, Ciccarone, Fabio, Caiafa, Paola, Zampieri, Michele, Caserta, Micaela

“…Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family…”
Get full text

TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition by Bamezai, Shiva, Demir, Deniz, Pulikkottil, Alex Jose, Ciccarone, Fabio, Fischbein, Elena, Sinha, Amit, Borga, Chiara, te Kronnie, Geertruy, Meyer, Lüder-Hinrich, Mohr, Fabian, Götze, Maria, Caiafa, Paola, Debatin, Klaus-Michael, Döhner, Konstanze, Döhner, Hartmut, González-Menéndez, Irene, Quintanilla-Fend, Leticia, Herold, Tobias, Jeremias, Irmela, Feuring-Buske, Michaela, Buske, Christian, Rawat, Vijay P. S.

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer characterized by skewed epigenetic patterns, raising the possibility of…”
Get full text

ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites by Zampieri, Michele, Guastafierro, Tiziana, Calabrese, Roberta, Ciccarone, Fabio, Bacalini, Maria G, Reale, Anna, Perilli, Mariagrazia, Passananti, Claudio, Caiafa, Paola

“…PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dnmt1 [DNA…”
Get more information

Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles by Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola

“…Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA…”
Get full text

Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide by Tentori, Lucio, Ricci-Vitiani, Lucia, Muzi, Alessia, Ciccarone, Fabio, Pelacchi, Federica, Calabrese, Roberta, Runci, Daniele, Pallini, Roberto, Caiafa, Paola, Graziani, Grazia

“…Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM…”
Get full text

CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery by Guastafierro, Tiziana, Cecchinelli, Barbara, Zampieri, Michele, Reale, Anna, Riggio, Giuseppe, Sthandier, Olga, Zupi, Gabriella, Calabrese, Lilia, Caiafa, Paola

“…Our previous data have shown that in L929 mouse fibroblasts the control of methylation pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose…”
Get full text

CCCTC-binding factor meets poly(ADP-ribose) polymerase-1 by Caiafa, Paola, Zlatanova, Jordanka

“…CCCTC‐binding factor (CTCF) is a ubiquitous Zn‐finger‐containing protein with numerous recognized functions, including, but not limited to, gene activation and…”
Get full text

Essential role of poly(ADP-ribosyl)ation in cocaine action by Scobie, Kimberly N., Damez-Werno, Diane, Sun, HaoSheng, Shao, NingYi, Gancarz, Amy, Panganiban, Clarisse H., Dias, Caroline, Koo, JaWook, Caiafa, Paola, Kaufman, Lewis, Neve, Rachael L., Dietz, David M., Li Shen, Nestler, Eric J.

“…Many of the long-term effects of cocaine on the brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin…”
Get full text

DNA methylation and chromatin structure: The puzzling CpG islands by Caiafa, Paola, Zampieri, Michele

“…DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto DNA. As for the distribution of 5mCs, it is well known that they…”
Get full text

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL by Tottone, Luca, Zhdanovskaya, Nadezda, Carmona Pestaña, Álvaro, Zampieri, Michele, Simeoni, Fabrizio, Lazzari, Sara, Ruocco, Valeria, Pelullo, Maria, Caiafa, Paola, Felli, Maria Pia, Checquolo, Saula, Bellavia, Diana, Talora, Claudio, Screpanti, Isabella, Palermo, Rocco

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch…”
Get full text

The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells by Zampieri, Michele, Ciccarone, Fabio, Palermo, Rocco, Cialfi, Samantha, Passananti, Claudio, Chiaretti, Sabina, Nocchia, Daniela, Talora, Claudio, Screpanti, Isabella, Caiafa, Paola

“…Aberrant upregulation of NOTCH3 gene plays a critical role in cancer pathogenesis. However, the underlying mechanisms are still unknown. We tested here the…”
Get full text

DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome by Ravaioli, Francesco, Zampieri, Michele, Morandi, Luca, Pirazzini, Chiara, Pellegrini, Camilla, De Fanti, Sara, Gensous, Noémie, Pirazzoli, Gian Luca, Sambati, Luisa, Ghezzo, Alessandro, Ciccarone, Fabio, Reale, Anna, Monti, Daniela, Salvioli, Stefano, Caiafa, Paola, Capri, Miriam, Bürkle, Alexander, Moreno-Villanueva, Maria, Garagnani, Paolo, Franceschi, Claudio, Bacalini, Maria Giulia

“…Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on…”
Get full text

Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project by Giacconi, Robertina, Costarelli, Laura, Piacenza, Francesco, Basso, Andrea, Bürkle, Alexander, Moreno-Villanueva, Maria, Grune, Tilman, Weber, Daniela, Stuetz, Wolfgang, Gonos, Efstathios S, Schön, Christiane, Grubeck-Loebenstein, Beatrix, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Franceschi, Claudio, Hervonen, Antti, Slagboom, Eline, Ciccarone, Fabio, Zampieri, Michele, Caiafa, Paola, Jansen, Eugène, Dollé, Martijn E T, Breusing, Nicolle, Mocchegiani, Eugenio, Malavolta, Marco

“…Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice…”
Get full text

Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity by Zampieri, Michele, Passananti, Claudio, Calabrese, Roberta, Perilli, Mariagrazia, Corbi, Nicoletta, De Cave, Fabiana, Guastafierro, Tiziana, Bacalini, Maria Giulia, Reale, Anna, Amicosante, Gianfranco, Calabrese, Lilia, Zlatanova, Jordanka, Caiafa, Paola

“…Aberrant hypermethylation of CpG islands in housekeeping gene promoters and widespread genome hypomethylation are typical events occurring in cancer cells. The…”
Get full text

Modulation of DNMT1 activity by ADP-ribose polymers by Reale, Anna, Matteis, Giovanna De, Galleazzi, Giada, Zampieri, Michele, Caiafa, Paola

“…We provided evidence that competitive inhibition of poly(ADP-ribose) polymerases in mammalian cells treated with 3-aminobenzamide causes DNA hypermethylation…”
Get full text