Search Results - "CACCIAPUOTI, Anthony"

Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors by WALKER, Scott S, YIMING XU, NORRIS, Christine, ANTONACCI, Barry, GURNANI, Maya, CACCIAPUOTI, Anthony, MCNICHOLAS, Paul M, WAINHAUS, Samuel, JASON HERR, R, KUANG, Rongze, ASLANIAN, Robert G, TING, Pauline C, TRIANTAFYLLOU, Ilias, BLACK, Todd A, WALDMAN, Michelle F, MENDRICK, Cara, BROWN, Nathaniel, MANN, Paul, CHAU, Andrew, PATEL, Reena, BAUMAN, Nicholas

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Pharmacodynamics of a New Triazole, Posaconazole, in a Murine Model of Disseminated Candidiasis by ANDES, D, MARCHILLO, K, CONKLIN, R, KRISHNA, Gopal, EZZET, Farkad, CACCIAPUOTI, Anthony, LOEBENBERG, David

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Interaction between Posaconazole and Caspofungin in Concomitant Treatment of Mice with Systemic Aspergillus Infection by Cacciapuoti, Anthony, Halpern, Judith, Mendrick, Cara, Norris, Christine, Patel, Reena, Loebenberg, David

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Activity of Posaconazole Combined with Amphotericin B against Aspergillus flavus Infection in Mice: Comparative Studies in Two Laboratories by NAJVAR, Laura K, CACCIAPUOTI, Anthony, HERNANDEZ, Steve, HALPERN, Judith, BOCANEGRA, Rosie, GURNANI, Maya, MENZEL, Frederick, LOEBENBERG, David, GRAYBILL, John R

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Interaction between Posaconazole and Amphotericin B in Concomitant Treatment against Candida albicans In Vivo by CACCIAPUOTI, Anthony, GURNANI, Maya, HALPERN, Judith, NORRIS, Christine, PATEL, Reena, LOEBENBERG, David

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Cytokine Networking in Lungs of Immunocompetent Mice in Response to Inhaled Aspergillus fumigatus by BRIELAND, Joan K, JACKSON, Craig, CHURAKOVA, Tatyana, ABRAMS, John, HARE, Roberta, O'GARRA, Anne, MENZEL, Fred, LOEBENBERG, David, CACCIAPUOTI, Anthony, HALPERN, Judy, HURST, Stephen, MUCHAMUEL, Tony, DEBETS, Reno, KASTELEIN, Rob

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Effect of Granulocyte Colony-Stimulating Factor Combination Therapy on Efficacy of Posaconazole (SCH56592) in an Inhalation Model of Murine Pulmonary Aspergillosis by PATERA, Andriani C, MENZEL, Frederick, JACKSON, Craig, BRIELAND, Joan K, HALPERN, Judy, HARE, Roberta, CACCIAPUOTI, Anthony, LOEBENBERG, David

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Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys by NOMEIR, A. A, KUMARI, P, HILBERT, M. J, GUPTA, S, LOEBENBERG, D, CACCIAPUOTI, A, HARE, R, MILLER, G. H, LIN, C.-C, CAYEN, M. N

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Inactivation of Sterol Δ5,6-Desaturase Attenuates Virulence in Candida albicans by CHAU, Andrew S, GURNANI, Maya, HAWKINSON, Robyn, LAVERDIERE, Michel, CACCIAPUOTI, Anthony, MCNICHOLAS, Paul M

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Efficacy of an Evernimicin (SCH27899) In Vitro and in an Animal Model of Lyme Disease by PAVIA, Charles S, WORMSER, Gary P, NOWAKOWSKI, John, CACCIAPUOTI, Anthony

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In Vitro and In Vivo Activities of SCH 56592 (Posaconazole), a New Triazole Antifungal Agent, againstAspergillus and Candida by Cacciapuoti, Anthony, Loebenberg, David, Corcoran, Erik, Menzel, Fred, Moss, Eugene L, Norris, Christine, Michalski, Monika, Raynor, Kimberly, Halpern, Judith, Mendrick, Cara, Arnold, Brian, Antonacci, Barry, Parmegiani, Raulo, Yarosh-Tomaine, Taisa, Miller, George H, Hare, Roberta S

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Nonfilamentous C. albicans Mutants Are Avirulent by Lo, Hsiu-Jung, Köhler, Julia R, DiDomenico, Beth, Loebenberg, David, Cacciapuoti, Anthony, Fink, Gerald R

“…Candida albicans and Saccharomyces cerevisiae switch from a yeast to a filamentous form. In Saccharomyces, this switch is controlled by two regulatory…”
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The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors by Ting, Pauline C., Kuang, Rongze, Wu, Heping, Aslanian, Robert G., Cao, Jianhua, Kim, David W., Lee, Joe F., Schwerdt, John, Zhou, Gang, Wainhaus, Samuel, Black, Todd A., Cacciapuoti, Anthony, McNicholas, Paul M., Xu, Yiming, Walker, Scott S.

“…A structure–activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2 H)-one 1 has resulted in the…”
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Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors by Zych, Andrew J., Lam, Sang Q., Jenkins, David M., Herr, R. Jason, Ting, Pauline C., Lee, Joe F., Kuang, Rongze, Wu, Heping, Kim, David W., Aslanian, Robert G., Wainhaus, Samuel, Black, Todd A., Cacciapuoti, Anthony, McNicholas, Paul M., Xu, Yiming, Walker, Scott S.

“…The structure–activity relationship studies of a novel sulfonylurea series of piperazine pyridazine-based small molecule glucan synthase inhibitors is…”
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The optimization of pyridazinone series of glucan synthase inhibitors by Kuang, Rongze, Wu, Heping, Ting, Pauline C., Aslanian, Robert G., Cao, Jianhua, Kim, David W., Lee, Joe F., Schwerdt, John, Zhou, Gang, Jason Herr, R., Zych, Andrew J., Yang, Jinhai, Lam, Sang Q., Jenkins, David M., Sakwa, Samuel A., Wainhaus, Samuel, Black, Todd A., Cacciapuoti, Anthony, McNicholas, Paul M., Xu, Yiming, Walker, Scott S.

“…A detailed structure–activity relationship study of a novel series of pyridazine-based small molecule glucan synthase inhibitors is described. The optimization…”
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Efficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats by Ullmann, Andrew J., Krammes, Erik, Sommer, Sita, Buschmann, Ines, Jahn-Muehl, Bernhard, Cacciapuoti, Anthony, Schmitt, Heinz-Josef

“…Objectives Invasive pulmonary aspergillosis is associated with high mortality. To assess new antifungal therapy options, animal models have to be developed to…”
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In vitro and in vivo activities of SCH 56592 (Posaconazole), a new triazole antifungal agent, against Aspergillus and Candida by CACCIAPUOTI, A, LOEBENBERG, D, ARNOLD, B, ANTONACCI, B, PARMEGIANI, R, YAROSH-TOMAINE, T, MILLER, G. H, HARE, R. S, CORCORAN, E, MENZEL, F. JR, MOSS, E. L, NORRIS, C, MICHALSKI, M, RAYNOR, K, HALPERN, J, MENDRICK, C

“…SCH 56592 (posaconazole), a new triazole antifungal agent, was tested in vitro, and its activity was compared to that of itraconazole against 39 Aspergillus…”
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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048) by Nomeir, Amin A, Pramanik, Birendra N, Heimark, Larry, Bennett, Frank, Veals, John, Bartner, Peter, Hilbert, Maryjane, Saksena, Anil, McNamara, Paul, Girijavallabhan, Viyyoor, Ganguly, Ashit K, Lovey, Raymond, Pike, Russell, Wang, Haiyan, Liu, Yi-Tsung, Kumari, Pramila, Korfmacher, Walter, Lin, Chin-Chung, Cacciapuoti, Anthony, Loebenberg, David, Hare, Roberta, Miller, George, Pickett, Cecil

“…Posaconazole (SCH 56592) is a novel triazole antifungal drug that is marketed in Europe and the United States under the trade name 'Noxafil' for prophylaxis…”
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Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans by Chau, Andrew S, Gurnani, Maya, Hawkinson, Robyn, Laverdiere, Michel, Cacciapuoti, Anthony, McNicholas, Paul M

“…Two clinical Candida albicans isolates that exhibited high-level resistance to azoles and modest decreases in susceptibility to amphotericin B were cultured…”
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Inactivation of Sterol Δ 5,6 -Desaturase Attenuates Virulence in Candida albicans by Chau, Andrew S., Gurnani, Maya, Hawkinson, Robyn, Laverdiere, Michel, Cacciapuoti, Anthony, McNicholas, Paul M.

“…Two clinical Candida albicans isolates that exhibited high-level resistance to azoles and modest decreases in susceptibility to amphotericin B were cultured…”
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