Search Results - "C. smyth"

Brain Pericytes As Mediators of Neuroinflammation by Rustenhoven, Justin, Jansson, Deidre, Smyth, Leon C, Dragunow, Mike

“…Brain pericytes are perivascular cells that regulate capillary function, and this localization puts them in a pivotal position for the regulation of central…”
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Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels by Mazzitelli, Jose A., Smyth, Leon C. D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan

“…It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull…”
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Quantifying the biophysical climate change mitigation potential of Canada's forest sector by Smyth, C. E, Stinson, G, Neilson, E, Lemprière, T. C, Hafer, M, Rampley, G. J, Kurz, W. A

“…The potential of forests and the forest sector to mitigate greenhouse gas (GHG) emissions is widely recognized, but challenging to quantify at a national…”
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Gastric cancer by Smyth, Elizabeth C, Nilsson, Magnus, Grabsch, Heike I, van Grieken, Nicole CT, Lordick, Florian

“…Gastric cancer is the fifth most common cancer and the third most common cause of cancer death globally. Risk factors for the condition include Helicobacter…”
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Ramucirumab: successfully targeting angiogenesis in gastric cancer by Javle, Milind, Smyth, Elizabeth C, Chau, Ian

“…Gastric cancer is the fourth most common cancer globally and represents the second most common cause of cancer-related mortality. Early detection, aggressive…”
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Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae by Brunaugh, Ashlee D, Seo, Hyojong, Warnken, Zachary, Ding, Li, Seo, Sang Heui, Smyth, Hugh D C

“…Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Though NIC is…”
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Tumor stage after neoadjuvant chemotherapy determines survival after surgery for adenocarcinoma of the esophagus and esophagogastric junction by Davies, Andrew R, Gossage, James A, Zylstra, Janine, Mattsson, Fredrik, Lagergren, Jesper, Maisey, Nick, Smyth, Elizabeth C, Cunningham, David, Allum, William H, Mason, Robert C

“…Neoadjuvant chemotherapy is established in the management of most resectable esophageal and esophagogastric junction adenocarcinomas. However, assessing the…”
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Carbon in Canada's boreal forest — A synthesis by Kurz, W.A., Shaw, C.H., Boisvenue, C., Stinson, G., Metsaranta, J., Leckie, D., Dyk, A., Smyth, C., Neilson, E.T.

“…Canada's managed boreal forest, 54% of the nation's total boreal forest area, stores 28 Pg carbon (C) in biomass, dead organic matter, and soil pools. The net…”
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inventory-based analysis of Canada's managed forest carbon dynamics, 1990 to 2008 by STINSON, G, KURZ, W.A, SMYTH, C.E, NEILSON, E.T, DYMOND, C.C, METSARANTA, J.M, BOISVENUE, C, RAMPLEY, G.J, LI, Q, WHITE, T.M, BLAIN, D

“…Canada's forests play an important role in the global carbon (C) cycle because of their large and dynamic C stocks. Detailed monitoring of C exchange between…”
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Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up by Obermannová, R., Alsina, M., Cervantes, A., Leong, T., Lordick, F., Nilsson, M., van Grieken, N.C.T., Vogel, A., Smyth, E.C.

“…•This ESMO Clinical Practice Guideline provides key recommendations for managing oesophageal cancer.•The guideline covers clinical and pathological diagnosis,…”
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Skull bone marrow channels as immune gateways to the central nervous system by Mazzitelli, Jose A., Pulous, Fadi E., Smyth, Leon C. D., Kaya, Zeynep, Rustenhoven, Justin, Moskowitz, Michael A., Kipnis, Jonathan, Nahrendorf, Matthias

“…Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull channels’)…”
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Late-line treatment in metastatic gastric cancer: today and tomorrow by Smyth, Elizabeth C., Moehler, Markus

“…Survival for patients with unresectable advanced or recurrent gastric cancer (GC) remains poor and the historical lack of evidence-based therapeutic options…”
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Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2–3 trial by Cunningham, David, Prof, Stenning, Sally P, Prof, Smyth, Elizabeth C, MBBCh, Okines, Alicia F, MD, Allum, William H, MD, Rowley, Sam, MSc, Stevenson, Laura, MSc, Grabsch, Heike I, Prof, Alderson, Derek, Prof, Crosby, Thomas, FRCR, Griffin, S Michael, Prof, Mansoor, Wasat, PhD, Coxon, Fareeda Y, MBBS, Falk, Stephen J, MD, Darby, Suzanne, MBChB, Sumpter, Kate A, MD, Blazeby, Jane M, Prof, Langley, Ruth E, Prof

“…Summary Background Peri-operative chemotherapy and surgery is a standard of care for patients with resectable oesophagogastric adenocarcinoma. Bevacizumab, a…”
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Immune Checkpoint Inhibitors in the Treatment of Gastroesophageal Cancer by Chénard-Poirier, Maxime, Smyth, Elizabeth C.

“…Immune checkpoint blockade has revolutionised the treatment of multiple cancers including melanoma, non-small cell lung cancer, urothelial and renal cell…”
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Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms by Armijo, Leisha M, Wawrzyniec, Stephen J, Kopciuch, Michael, Brandt, Yekaterina I, Rivera, Antonio C, Withers, Nathan J, Cook, Nathaniel C, Huber, Dale L, Monson, Todd C, Smyth, Hugh D C, Osiński, Marek

“…Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common…”
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Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments by Zhang, Hairui, Leal, Jasmim, Soto, Melissa R., Smyth, Hugh D. C., Ghosh, Debadyuti

“…Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and…”
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Unique and shared inflammatory profiles of human brain endothelia and pericytes by Smyth, Leon C D, Rustenhoven, Justin, Park, Thomas I-H, Schweder, Patrick, Jansson, Deidre, Heppner, Peter A, O'Carroll, Simon J, Mee, Edward W, Faull, Richard L M, Curtis, Maurice, Dragunow, Mike

“…Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the…”
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Encouraging results for PD-1 inhibition in gastric cancer by Smyth, Elizabeth C, Cunningham, David

“…[...]it is unclear whether the radiological responses that have been reported in seemingly PD-L1-negative patients treated with anti-PD1 therapies in…”
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Measurements of nonlinear lensing in a semiconductor disk laser gain sample under optical pumping and using a resonant femtosecond probe laser by Quarterman, A. H., Mirkhanov, S., Smyth, C. J. C., Wilcox, K. G.

“…Accurate characterizations of the nonlinear refractive index of semiconductor disk laser (SDL) gain samples are of critical importance for understanding the…”
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CBM-CFS3: A model of carbon-dynamics in forestry and land-use change implementing IPCC standards by Kurz, W.A., Dymond, C.C., White, T.M., Stinson, G., Shaw, C.H., Rampley, G.J., Smyth, C., Simpson, B.N., Neilson, E.T., Trofymow, J.A., Metsaranta, J., Apps, M.J.

“…The scientific community, forest managers, environmental organizations, carbon-offset trading systems and policy-makers require tools to account for forest…”
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