Search Results - "C. Williams, Niamh"

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation by Williams, Niamh C, O'Neill, Luke A J

“…Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The…”
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Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease by Healy, Claire, Munoz-Wolf, Natalia, Strydom, Janné, Faherty, Lynne, Williams, Niamh C, Kenny, Sarah, Donnelly, Seamas C, Cloonan, Suzanne M

“…Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading…”
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Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling by Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., C. Williams, Niamh, Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan, O’Neill, Luke A. J.

“…MyD88 adaptor-like (MAL) is a critical protein in innate immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition…”
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Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses by Lundahl, Mimmi L E, Mitermite, Morgane, Ryan, Dylan Gerard, Case, Sarah, Williams, Niamh C, Yang, Ming, Lynch, Roisin I, Lagan, Eimear, Lebre, Filipa M, Gorman, Aoife L, Stojkovic, Bojan, Bracken, Adrian P, Frezza, Christian, Sheedy, Frederick J, Scanlan, Eoin M, O'Neill, Luke A J, Gordon, Stephen V, Lavelle, Ed C

“…Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the 'classically activated' M1 macrophage enhances…”
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ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation by Santarsiero, Anna, Convertini, Paolo, Todisco, Simona, Pierri, Ciro L, De Grassi, Anna, Williams, Niamh C, Iacobazzi, Dominga, De Stefano, Giulio, O'Neill, Luke A J, Infantino, Vittoria

“…Macrophage stimulation by pathogen-associated molecular patterns (PAMPs) like lipopolysaccharide (LPS) or lipoteichoic acid (LTA) drives a proinflammatory…”
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Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD by Fan, Li-Chao, McConn, Keith, Plataki, Maria, Kenny, Sarah, Williams, Niamh C, Kim, Kihwan, Quirke, Jennifer A, Chen, Yan, Sauler, Maor, Möbius, Matthias E, Chung, Kuei-Pin, Area Gomez, Estela, Choi, Augustine Mk, Xu, Jin-Fu, Cloonan, Suzanne M

“…Alveolar epithelial type II (AEC2) cells strictly regulate lipid metabolism to maintain surfactant synthesis. Loss of AEC2 cell function and surfactant…”
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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages by Williams, Niamh C., Ryan, Dylan G., Costa, Ana S.H., Mills, Evanna L., Jedrychowski, Mark P., Cloonan, Suzanne M., Frezza, Christian, O'Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific…”
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Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice by Cloonan, Suzanne M, Glass, Kimberly, Laucho-Contreras, Maria E, Bhashyam, Abhiram R, Cervo, Morgan, Pabón, Maria A, Konrad, Csaba, Polverino, Francesca, Siempos, Ilias I, Perez, Elizabeth, Mizumura, Kenji, Ghosh, Manik C, Parameswaran, Harikrishnan, Williams, Niamh C, Rooney, Kristen T, Chen, Zhi-Hua, Goldklang, Monica P, Yuan, Guo-Cheng, Moore, Stephen C, Demeo, Dawn L, Rouault, Tracey A, D'Armiento, Jeanine M, Schon, Eric A, Manfredi, Giovanni, Quackenbush, John, Mahmood, Ashfaq, Silverman, Edwin K, Owen, Caroline A, Choi, Augustine M K

“…Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke–induced chronic obstructive pulmonary…”
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ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming by Williams, Niamh C., O’Neill, Luke A.

“…Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al. now show that early…”
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