Search Results - "C. R. Benedict"

A Simple Strategy for Crystal Engineering Water Clusters by Sansam, Benedict C. R, Anderson, Kirsty M, Steed, Jonathan W

“…We report the X-ray crystal structure of the protonated phenazine-2,3-diamine cation (3) salt (3)2SeO4·6H2O (4), which contains a discrete water decamer. This…”
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Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein IIb/IIIa-dependent mechanism by MERTEN, M, PAKALA, R, THIAGARAJAN, P, BENEDICT, C. R

“…Platelets, on activation, release vesicular particles called platelet microparticles. Despite their procoagulant activity, their functional role in…”
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Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels by Kuryshev, Y A, Brown, A M, Wang, L, Benedict, C R, Rampe, D

“…Administration of the 5-hydroxytryptamine 3 receptor class of antiemetic agents has been associated with prolongation in the QRS, JT, and QT intervals of the…”
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Inhibition of arterial thrombosis by recombinant annexin V in a rabbit carotid artery injury model by THIAGARAJAN, P, BENEDICT, C. R

“…The procoagulant effect of anionic phospholipid may play a major role in the development of arterial thrombosis. Annexin V, a calcium-dependent…”
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Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection by LONN, E. M, YUSUF, S, PRABHAT JHA, MONTAGUE, T. J, TEO, K. K, BENEDICT, C. R, PITT, B

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Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis by WEINBERG, E. O, SCHOEN, F. J, GEORGE, D, KAGAYA, Y, DOUGLAS, P. S, LITWIN, S. E, SCHUNKERT, H, BENEDICT, C. R, LORELL, B. H

“…We tested the hypotheses that long-term administration of the angiotensin-converting enzyme (ACE) inhibitor fosinopril will regress hypertrophy, modify the…”
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New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA by BENEDICT, C. R, REFINO, C. J, KEYT, B. A, PAKALA, R, PAONI, N. F, THOMAS, G. R, BENNETT, W. F

“…The thrombolytic properties of a new variant of tissue plasminogen activator (TPA) (T103N, N117Q, KHRR 296-299 AAAA, or TNK-TPA) with longer plasma half-life,…”
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The Cyclization of Farnesyl Diphosphate and Nerolidyl Diphosphate by a Purified Recombinant δ-Cadinene Synthase by Chauncey R. Benedict, Jia-Ling Lu, Pettigrew, Donald W., Jinggao Liu, Stipanovic, Robert D., Williams, Howard J.

“…The first step in the conversion of the isoprenoid intermediate, farnesyl diphosphate (FDP), to sesquiterpene phytoalexins in cotton (Gossypium barbadense)…”
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Synergistic interaction between thromboxane A2 and mildly oxidized low density lipoproteins on vascular smooth muscle cell proliferation by KOBA, S, PAKALA, R, WATANABE, T, KATAGIRI, T, BENEDICT, C. R

“…Low density lipoprotein (LDL) and mildly oxidized low density lipoprotein (mox-LDL) are known mitogens for vascular smooth muscle cell (VSMC). Since…”
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Frequency and Severity of Cyclic Flow Alternations and Platelet Aggregation Predict the Severity of Neointimal Proliferation Following Experimental Coronary Stenosis and Endothelial Injury by Willerson, James T., Yao, Sheng-Kun, McNatt, Janice, Benedict, Claude R., Anderson, H. Vernon, Golino, Paolo, Murphree, Sidney S., Buja, L. Maximilian

“…The role of recurrent platelet aggregation in the development of neointimal proliferation of coronary arteries was explored in this study, and the hypothesis…”
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Safe and effective management of hypertension with fixed-dose combination therapy: focus on losartan plus hydrochlorothiazide by Benedict, C R

“…Treatment of hypertensive patients with fixed-dose combination therapy consisting of losartan and hydrochlorothiazide (HCTZ) has several potential benefits…”
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Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid by PAKALA, Rajbabu, PAKALA, Rajashree, BENEDICT, C. R

“…Thromboxane A2 (TXA2) released from aggregating platelets and injured vessel wall stimulates smooth muscle cell proliferation, which may contribute to the…”
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Dominance of Charge-Assisted Hydrogen Bonding on Short Contacts and Structures that Crystallize with Z′ > 1 by Anderson, Kirsty M, Goeta, Andrés E, Martin, Jessica E, Mason, Sax A, McIntyre, Garry J, Sansam, Benedict C. R, Wilkinson, Clive, Steed, Jonathan W

“…An enantiotropic pair of polymorphs of (H2-o-PDA2+)4(H5O2 +)(SO4 2–)4(HSO4 –)·2H2O (1) interconvert at 140–142 K with a concomitant change in Z′. The details…”
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Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology by VAN DEN BERG, E. G, SCHMITZ, J. M, BENEDICT, C. R, MALLOY, C. R, WILLERSON, J. T, DEHMER, G. J

“…Serotonin is released by activated platelets and may act as a mediator to initiate or sustain certain unstable syndromes of ischemic heart disease in humans…”
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Single-Blind Study of the Effects of Intravenous Dolasetron Mesylate Versus Ondansetron on Electrocardiographic Parameters in Normal Volunteers by Benedict, Claude R, Arbogast, Robert, Martin, Lorene, Patton, Lavonne, Morrill, Bruce, Hahne, William

“…SUMMARYA single-blind, randomized, five-way crossover, safety and tolerability trial was conducted to determine whether intravenous (i.v.) dolasetron mesylate…”
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Local Effect of Serotonin Released during Coronary Angioplasty by Golino, Paolo, Piscione, Federico, Benedict, Claude R, Anderson, H. Vernon, Cappelli-Bigazzi, Maurizio, Indolfi, Ciro, Condorelli, Mario, Chiariello, Massimo, Willerson, James T

“…Recent experimental and clinical observations indicate that intracoronary platelet activation at sites of endothelial injury and coronary-artery stenosis may…”
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ADP Plays an Important Role in Mediating Platelet Aggregation and Cyclic Flow Variations In Vivo in Stenosed and Endothelium-Injured Canine Coronary Arteries by Yao, Sheng-Kun, Ober, Judy C, McNatt, Janice, Benedict, Claude R, Rosolowsky, Mark, Anderson, H Vernon, Cui, Kexin, Maffrand, Jean-Pierre, Campbell, William B, Buja, L Maximilian, Willerson, James T

“…The goal of this study was to test the hypotheses that endogenous ADP plays an important role in vivo in mediating platelet aggregation and cyclic coronary…”
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Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids by Pakala, Rajashree, Pakala, Rajbaeu, Radcliffe, J.D., Benedict, C.R.

“…Serotonin (5HT) released from aggregating platelets at sites of vascular injury is a known mitogen for vascular endothelial cells. Recent studies have…”
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Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries by ASHTON, J. H, BENEDICT, C. R, FITZGERALD, C, RAHEJA, S, TAYLOR, A, CAMPBELL, W. B, MAXIMILIAN BUJA, L, WILLERSON, J. T

“…The data obtained in this study demonstrate that the concentration of serotonin is markedly elevated (18- to 27-fold) at the site of a coronary arterial…”
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Differential induction of 3-hydroxy-3-methylglutaryl CoA reductase in two cotton species following inoculation with Verticillium by JOOST, O, BIANCHINI, G, BELL, A. A, BENEDICT, C. R, MAGILL, C. W

“…Gossypium barbadense cottons are typically more resistant to wilt pathogens than are Gossypium hirsutum cultivars. Both species make terpenoid phytoalexins in…”
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