Search Results - "C. Leann Hinkle"

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability by Sunnarborg, Susan Wohler, Hinkle, C. Leann, Stevenson, Mary, Russell, William E., Raska, Christina S., Peschon, Jacques J., Castner, Beverly J., Gerhart, Mary J., Paxton, Raymond J., Black, Roy A., Lee, David C.

“…We previously implicated tumor necrosis factor-α converting enzyme (TACE/ADAM17) in the processing of the integral membrane precursor to soluble transforming…”
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TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase by LEE, DAVID C., SUNNARBORG, SUSAN WOHLER, HINKLE, C. LEANN, MYERS, TIMOTHY J., STEVENSON, MARY, RUSSELL, WILLIAM E., CASTNER, BEVERLY J., GERHART, MARY J., PAXTON, RAYMOND J., BLACK, ROY A., CHANG, AILEEN, JACKSON, LESLIE F.

“…: EGF family growth factors, including transforming growth factor‐alpha (TGFα), amphiregulin (AR), and heparin‐binding EGF (HB‐EGF), are invariably expressed…”
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Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency by Hinkle, C Leann, Sunnarborg, Susan W, Loiselle, David, Parker, Carol E, Stevenson, Mary, Russell, William E, Lee, David C

“…Epidermal growth factor (EGF) family ligands are derived by proteolytic cleavage of the ectodomains of integral membrane precursors. Previously, we established…”
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NCAM140 stimulates integrin‐dependent cell migration by ectodomain shedding by Diestel, Simone, Hinkle, C. Leann, Schmitz, Brigitte, Maness, Patricia F.

“…The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration and synaptic plasticity. This study describes a novel function of…”
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Metalloprotease‐induced ectodomain shedding of neural cell adhesion molecule (NCAM) by Hinkle, C. Leann, Diestel, Simone, Lieberman, Jeffrey, Maness, Patricia F.

“…Transmembrane forms of neural cell adhesion molecule (NCAM140, NCAM1801) are key regulators of neuronal development. The extracellular domain of NCAM can occur…”
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Multiple Metalloproteinases Process Protransforming Growth Factor-α (ProTGF-α) by Hinkle, C. Leann, Mohan, Mohita J, Lin, Peiyuan, Yeung, Nolan, Rasmussen, Fred, Milla, Marcos E, Moss, Marcia L

“…Shedding of TNF-α requires a single cleavage event, whereas the ectodomain of proTGF-α is cleaved at N-proximal (N-terminal) and membrane proximal (C-terminal)…”
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Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family by C. Leann Hinkle, Susan W. Sunnarborg, David Loiselle, Carol E. Parker, Mary Stevenson, William E. Russell, David C. Lee

“…Epidermal growth factor (EGF) family ligands are derived by proteolytic cleavage of the ectodomains of integral membrane precursors. Previously, we established…”
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Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family by Hinkle, C. Leann, Sunnarborg, Susan W., Loiselle, David, Parker, Carol E., Stevenson, Mary, Russell, William E., Lee, David C.

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Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability by Susan Wohler Sunnarborg, C. Leann Hinkle, Mary Stevenson, William E. Russell, Christina S. Raska, Jacques J. Peschon, Beverly J. Castner, Mary J. Gerhart, Raymond J. Paxton, Roy A. Black, David C. Lee

“…We previously implicated tumor necrosis factor-α converting enzyme (TACE/ADAM17) in the processing of the integral membrane precursor to soluble transforming…”
Get full text