Search Results - "C J Allegra"

Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients by PARADISO, A, SIMONE, G, JOHNSTON, P. G, PETRONI, S, LEONE, B, VALLEJO, C, LACAVA, J, ROMERO, A, MACHIAVELLI, M, DE LENA, M, ALLEGRA, C. J

“…The purpose of this work was to analyse the ability of p53 and thymidilate synthase (TS) primary tumour expression to retrospectively predict clinical response…”
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The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer by Johnston, P G, Fisher, E R, Rockette, H E, Fisher, B, Wolmark, N, Drake, J C, Chabner, B A, Allegra, C J

“…We assessed the prognostic importance of the level of thymidylate synthase (TS) expression in patients with primary rectal cancer and whether, for Dukes' B and…”
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Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors by JOHNSTON, P. G, LENZ, H.-J, LEICHMAN, C. G, DANENBERG, K. D, ALLEGRA, C. J, DANENBERG, P. V, LEICHMAN, L

“…Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). We have correlated TS protein and gene expression with the response in patients with…”
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Prognostic importance of thymidylate synthase expression in early breast cancer by Pestalozzi, B C, Peterson, H F, Gelber, R D, Goldhirsch, A, Gusterson, B A, Trihia, H, Lindtner, J, Cortés-Funes, H, Simmoncini, E, Byrne, M J, Golouh, R, Rudenstam, C M, Castiglione-Gertsch, M, Allegra, C J, Johnston, P G

“…To assess the prognostic importance of thymidylate synthase (TS) expression in breast tumors of patients with early-stage breast cancer, and to determine…”
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Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency by C H Takimoto, Z H Lu, R Zhang, M D Liang, L V Larson, L R Cantilena, Jr, J L Grem, C J Allegra, R B Diasio, E Chu

“…Patients with decreased dihydropyrimidine dehydrogenase (DPD) activity are at increased risk for experiencing serious adverse reactions following…”
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Autoregulation of Human Thymidylate Synthase Messenger RNA Translation by Thymidylate Synthase by Chu, Edward, Koeller, David M., Casey, John L., Drake, James C., Chabner, Bruce A., Elwood, Patrick C., Zinn, Sydelle, Allegra, Carmen J.

“…Thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) is essential for the de novo synthesis of thymidylate, a…”
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Dihydropyrimidine dehydrogenase activity: prognostic partner of 5-fluorouracil? by Allegra, C J

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Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma by Chu, E, Koeller, D M, Johnston, P G, Zinn, S, Allegra, C J

“…The effects of fluorouracil (5-FU) and interferon-gamma (IFN-gamma) on the regulation of thymidylate synthase (TS) gene expression were investigated in the…”
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Identification of an RNA Binding Site for Human Thymidylate Synthase by Chu, Edward, Voeller, Donna, Koeller, David M., Drake, James C., Takimoto, Chris H., Maley, Gladys F., Maley, Frank, Allegra, Carmen J.

“…Previous studies from this laboratory have shown that human TS mRNA translation is regulated by its protein product in a negative autoregulatory manner. In…”
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Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil by Copur, Sitki, Aiba, Keisuke, Drake, James C., Allegra, Carmen J., Chu, Edward

“…A series of 5-fluorouracil (5-FU)-resistant human colon H630 cancer cell lines were established by continuous exposure of cells to 5-FU. The concentration of…”
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Randomized clinical trial comparing mitoxantrone with doxorubicin in previously treated patients with metastatic breast cancer by Henderson, I C, Allegra, J C, Woodcock, T, Wolff, S, Bryan, S, Cartwright, K, Dukart, G, Henry, D

“…Three hundred twenty-five women with metastatic adenocarcinoma of the breast who had failed one prior chemotherapeutic regimen for advanced disease were…”
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Molecular Heterogeneity and Function of EWS-WT1 Fusion Transcripts in Desmoplastic Small Round Cell Tumors by JUN LIU, NAU, Marion M, YEH, Jimmy C, ALLEGRA, Carmen J, CHU, Edward, WRIGHT, John J

“…Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma with a consistent cytogenetic abnormality, t(11;22)(p13;q12). This chromosomal translocation…”
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Immunohistochemical determination of thymidylate synthase in colorectal cancer—methodological studies by Edler, D., Blomgren, H., Allegra, C.J., Johnston, P.G., Lagerstedt, U., Magnusson, I., Ragnhammar, P.

“…With the aid of specific monoclonal antibodies, an immunohistochemical technique has recently been developed for the detection of intratumoral thymidylate…”
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Reactivation of chronic hepatitis B infection following intensive chemotherapy and successful treatment with lamivudine: A case report and review of the literature by Wasif Saif, M., Little, R. F., Hamilton, J. M., Allegra, C. J., Wilson, W. H.

“…Background Hepatitus B virus reactivation has been reported in cancer patients following administration of chemotherapy or immunosuppressive therapy and may…”
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Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer by Swain, S M, Lippman, M E, Egan, E F, Drake, J C, Steinberg, S M, Allegra, C J

“…The efficacy and toxicity of leucovorin 500 mg/m2 administered intravenously (IV) over 30 minutes daily for five days followed in one hour by fluorouracil…”
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Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer by JOHNSTON, P. G, MICK, R, RECANT, W, BEHAN, K. A, DOLAN, M. E, RATAIN, M. J, BECKMANN, E, WEICHSELBAUM, R. R, ALLEGRA, C. J, VOKES, E. E

“…Thymidylate synthase (TS), an essential enzyme in DNA synthesis, is a target for the fluoropyrimidines, an important group of antineoplastic agents used widely…”
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Physical interaction between p53 and primary response gene Egr-1 by Liu, J, Grogan, L, Nau, M M, Allegra, C J, Chu, E, Wright, J J

“…The tumor suppressor p53 and primary response gene Egr-1 are nuclear transcription factors with regulatory roles in signal transduction pathways mediating…”
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Polyglutamation of methotrexate: is methotrexate a prodrug? by CHABNER, B. A, ALLEGRA, C. J, CURT, G. A, CLENDENINN, N. J, BARAM, J, KOIZUMI, S, DRAKE, J. C, JOLIVET, J

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Antifolates: the next millennium by Allegra, C J

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Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates by Allegra, C J, Chabner, B A, Drake, J C, Lutz, R, Rodbard, D, Jolivet, J

“…We have studied the effects of methotrexate (MTX-Glu1) and the polyglutamate derivatives of methotrexate (MTXPGs) with 2, 3, 4, and 5 glutamyl residues on the…”
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