Search Results - "Côté, Graham P."

Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion by Hoskin, Victoria, Szeto, Alvin, Ghaffari, Abdi, Greer, Peter A, Côté, Graham P, Elliott, Bruce E

“…Up-regulation of the cytoskeleton linker protein ezrin frequently occurs in aggressive cancer types and is closely linked with metastatic progression. However,…”
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Characterization of the Catalytic and Nucleotide Binding Properties of the α-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A by Yang, Yidai, Ye, Qilu, Jia, Zongchao, Côté, Graham P.

“…The α-kinases are a widely expressed family of serine/threonine protein kinases that exhibit no sequence identity with conventional eukaryotic protein kinases…”
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Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation by Ye, Qilu, Yang, Yidai, van Staalduinen, Laura, Crawley, Scott William, Liu, Linda, Brennan, Stephanie, Côté, Graham P., Jia, Zongchao

“…The α-kinases are a family of a typical protein kinases present in organisms ranging from protozoa to mammals. Here we report an autoinhibited conformation for…”
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Structure of the Single-lobe Myosin Light Chain C in Complex with the Light Chain-binding Domains of Myosin-1C Provides Insights into Divergent IQ Motif Recognition by Langelaan, David N., Liburd, Janine, Yang, Yidai, Miller, Emily, Chitayat, Seth, Crawley, Scott W., Côté, Graham P., Smith, Steven P.

“…Myosin light chains are key regulators of class 1 myosins and typically comprise two domains, with calmodulin being the archetypal example. They bind IQ motifs…”
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Formation of Extracellular Matrix-Digesting Invadopodia by Primary Aortic Smooth Muscle Cells by Furmaniak-Kazmierczak, Emilia, Crawley, Scott W, Carter, Rhonda L, Maurice, Donald H, Côté, Graham P

“…Invasion of the subendothelial space by vascular smooth muscle cells (VSMCs) contributes to the development and progression of diverse cardiovascular diseases…”
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Crystal structure of the alpha-kinase domain of Dictyostelium myosin heavy chain kinase A by Ye, Qilu, Crawley, Scott W, Yang, Yidai, Côté, Graham P, Jia, Zongchao

“…Dictyostelium discoideum myosin II heavy chain kinase A (MHCK A) disrupts the assembly and cellular activity of bipolar filaments of myosin II by…”
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Identification of dimer interactions required for the catalytic activity of the TRPM7 alpha-kinase domain by Crawley, Scott W, Côté, Graham P

“…TRPM7 (transient receptor potential melastatin) combines an ion channel domain with a C-terminal protein kinase domain that belongs to the atypical…”
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Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the α-Kinase Domain by Crawley, Scott W., Gharaei, Mojdeh Samimi, Ye, Qilu, Yang, Yidai, Raveh, Barak, London, Nir, Schueler-Furman, Ora, Jia, Zongchao, Côté, Graham P.

“…Dictyostelium discoideum myosin II heavy chain kinase A (MHCK A), a member of the atypical α-kinase family, phosphorylates sites in the myosin II tail that…”
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Structure of the Small Dictyostelium discoideum Myosin Light Chain MlcB Provides Insights into MyoB IQ Motif Recognition by Liburd, Janine, Chitayat, Seth, Crawley, Scott W., Munro, Kim, Miller, Emily, Denis, Chris M., Spencer, Holly L., Côté, Graham P., Smith, Steven P.

“…Dictyostelium discoideum MyoB is a class I myosin involved in the formation and retraction of membrane projections, cortical tension generation, membrane…”
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E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300 by Hyndman, Brandy D., Thompson, Patrick, Bayly, Richard, Côté, Graham P., LeBrun, David P.

“…The E2A gene encodes the E-protein transcription factors E12 and E47 that play critical roles in B-lymphopoiesis. A somatic chromosomal translocation…”
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A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency by Dieckmann, Régis, von Heyden, Yosuke, Kistler, Claudia, Gopaldass, Navin, Hausherr, Stéphanie, Crawley, Scott William, Schwarz, Eva C, Diensthuber, Ralph P, Côté, Graham P, Tsiavaliaris, Georgios, Soldati, Thierry

“…Actin dynamics and myosin (Myo) contractile forces are necessary for formation and closure of the phagocytic cup. In Dictyostelium, the actin-binding protein…”
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PakB binds to the SH3 domain of Dictyostelium Abp1 and regulates its effects on cell polarity and early development by Yang, Yidai, de la Roche, Marc, Crawley, Scott W, Li, Zhihao, Furmaniak-Kazmierczak, Emilia, Côté, Graham P

“…Dictyostelium p21-activated kinase B (PakB) phosphorylates and activates class I myosins. PakB colocalizes with myosin I to actin-rich regions of the cell,…”
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Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase by Crawley, Scott W., Côté, Graham P.

“…The α kinases are a widespread family of atypical protein kinases characterized by a novel type of catalytic domain. In this paper the peptide substrate…”
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Identification of Calmodulin and MlcC as Light Chains for Dictyostelium Myosin-I Isozymes by Crawley, Scott W, Liburd, Janine, Shaw, Kristopher, Jung, Yoojin, Smith, Steven P, Côté, Graham P

“…Dictyostelium discoideum express seven single-headed myosin-I isozymes (MyoA-MyoE and MyoK) that drive motile processes at the cell membrane. The light chains…”
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PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner by Webb, Bradley A, Eves, Robert, Crawley, Scott W, Zhou, Shutang, Côté, Graham P, Mak, Alan S

“…Remodeling of the vascular smooth muscle cytoskeleton is essential for cell motility involved in the development of diseases such as arteriosclerosis and…”
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Identification and Characterization of an 8-kDa Light Chain Associated with Dictyostelium discoideum MyoB, a Class I Myosin by Crawley, Scott W., de la Roche, Marc A., Lee, Sheu-Fen, Li, Zhihao, Chitayat, Seth, Smith, Steven P., Côté, Graham P.

“…Dictyostelium discoideum MyoB is a single-headed class I myosin. Analysis of purified MyoB by SDS-PAGE indicated the presence of an ∼9-kDa light chain. A…”
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Signaling pathways regulating Dictyostelium myosin II by De la Roche, Marc A, Smith, Janet L, Betapudi, Venkaiah, Egelhoff, Thomas T, Côté, Graham P

“…Dictyostelium myosin II is a conventional, two-headed myosin that consists of two copies each of a myosin heavy chain (MHC), an essential light chain (ELC) and…”
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Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB by de la Roche, Marc, Mahasneh, Amjad, Lee, Sheu-Fen, Rivero, Francisco, Côté, Graham P

“…Dictyostelium PakB, previously termed myosin I heavy chain kinase, is a member of the p21-activated kinase (PAK) family. Two-hybrid assays showed that PakB…”
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The Apolipoprotein(a) Component of Lipoprotein(a) Stimulates Actin Stress Fiber Formation and Loss of Cell-Cell Contact in Cultured Endothelial Cells by Pellegrino, Mark, Furmaniak-Kazmierczak, Emilia, LeBlanc, Justin C., Cho, Taewoo, Cao, Kathy, Marcovina, Santica M., Boffa, Michael B., Côté, Graham P., Koschinsky, Marlys L.

“…Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a risk factor for a variety of atherosclerotic disorders including coronary heart disease. In the…”
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Regulation of Dictyostelium Myosin I and II by de la Roche, Marc A., Côté, Graham P.

“…Dictyostelium expresses 12 different myosins, including seven single-headed myosins I and one conventional two-headed myosin II. In this review we focus on the…”
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