Search Results - "Côrtes, Steyner F."

Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress by Silva, Grazielle Caroline, Abbas, Malak, Khemais-Benkhiat, Sonia, Burban, Melanie, Ribeiro, Thais Porto, Toti, Florence, Idris-Khodja, Noureddine, Côrtes, Steyner F., Schini-Kerth, Valérie B.

“…Endothelial senescence has been suggested to promote endothelial dysfunction in age-related vascular disorders. This study evaluated the prothrombotic…”
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Definition of chemical markers for Hancornia speciosa Gomes by chemometric analysis based on the chemical composition of extracts, their vasorelaxant effect and α-glucosidase inhibition by Pereira, Ana Bárbara D., Gomes, José Hugo de Sousa, Pereira, Aline Carvalho, Pádua, Rodrigo Maia de, Côrtes, Steyner F., Sena, Marcelo Martins, Braga, Fernão Castro

“…ETHNOPHARMACOLOGICAL RELEVANCEHancornia speciosa Gomes (Apocynaceae) is a tree found in the Brazilian savannah, traditionally used to treat several diseases,…”
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Forced degradation of l-(+)-bornesitol, a bioactive marker of Hancornia speciosa: Development and validation of stability indicating UHPLC-MS method and effect of degraded products on ACE inhibition by Gomes, José Hugo de Sousa, da Silva, Grazielle Caroline, Côrtes, Steyner F., de Pádua, Rodrigo Maia, Braga, Fernão Castro

“…The antihypertensive activity of the medicinal plant Hancornia speciosa has been previously demonstrated by us, being the activity ascribed to polyphenols and…”
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Ketamine Activates the l-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway to Induce Peripheral Antinociception in Rats by Romero, Thiago R. L., Galdino, Giovane S., Silva, Grazielle C., Resende, Lívia C., Perez, Andréa C., Côrtes, Steyner F., Duarte, Igor D. G.

“…The involvement of the L-arginine/nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway in antinociception has been implicated as a molecular…”
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Structure-related blockage of calcium channels by vasodilator alkamides in mice mesenteric artery by Garcia, Daniela C.G, Pereira, Aline C, Gutierrez, Stanley J.C, Barbosa-Filho, José Maria, Lemos, Virgínia S, Côrtes, Steyner F

“…Abstract The development of new calcium channel blockers is still relevant for the understanding of their physiological role and pharmacological and…”
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Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases by Costa, Eduardo D, Rezende, Bruno A, Cortes, Steyner F, Lemos, Virginia S

“…The family of nitric oxide synthases (NOS) has significant importance in various physiological mechanisms and is also involved in many pathological processes…”
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Vascular effects of flavonoids by Almeida Rezende, Bruno, Pereira, Aline Carvalho, Cortes, Steyner F, Lemos, Virginia Soares

“…Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including…”
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Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis by Vieira-Alves, Ildernandes, Coimbra-Campos, Leda M C, Sancho, Maria, da Silva, Rafaela Fernandes, Cortes, Steyner F, Lemos, Virgínia Soares

“…Atherosclerosis constitutes a major risk factor for cardiovascular diseases, the leading cause of morbidity and mortality worldwide. This slowly progressing,…”
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TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection by Vieira-Alves, Ildernandes, Alves, Antonielle Rodrigues Pereira, Souza, Natália Muradas Valério, Melo, Tales Leonardo de, Coimbra Campos, Leda Maria de Castro, Lacerda, Larisse de Souza Barbosa, Queiroz-Junior, Celso Martins, Andrade, Ana Cláudia Dos Santos Pereira, Barcelos, Luciola Silva, Teixeira, Mauro Martins, Costa, Vivian Vasconcelos, Cortes, Steyner F, Lemos, Virginia S

“…Poor disease outcomes and lethality are directly related to endothelial dysfunction in betacoronavirus infections. Here, we investigated the mechanisms…”
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Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries by Côrtes, Steyner F, Rezende, Bruno A, Corriu, Catherine, Medeiros, Isac A, Teixeira, Mauro M, Lopes, Miguel José, Lemos, Virgínia S

“…The hypotensive and vasorelaxant effect of dioclein in resistance mesenteric arteries was studied in intact animals and isolated vessels, respectively. In…”
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The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant Hancornia speciosa by Moreira, Luciana N., Silva, Grazielle C., Câmara, Diógenes V., Pádua, Rodrigo M., Lemos, Virgínia S., Braga, Fernão C., Cortes, Steyner F.

“…The cyclitol bornesitol is the main constituent of the leaves from the antihypertensive medicinal plant Hancornia speciosa. This study aimed to investigate the…”
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Endothelial dysfunction in DOCA-salt-hypertensive mice: role of neuronal nitric oxide synthase-derived hydrogen peroxide by Silva, Grazielle C, Silva, Josiane F, Diniz, Thiago F, Lemos, Virginia S, Cortes, Steyner F

“…Endothelial dysfunction is a common problem associated with hypertension and is considered a precursor to the development of micro- and macro-vascular…”
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Angiotensin‐(1‐7) is involved in the endothelium‐dependent modulation of phenylephrine‐induced contraction in the aorta of mRen‐2 transgenic rats by Lemos, Virgínia S, Côrtes, Steyner F, Silva, Denise M R, Campagnole‐Santos, Maria J, Santos, Robson A S

“…The contribution of the local vascular production of angiotensin‐(1‐7) [Ang‐(1‐7)] to the control of α‐adrenergic‐induced contractions in the aorta of…”
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Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta by Capettini, Luciano S.A., Cortes, Steyner F., Lemos, Virginia S.

“…In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial nitric oxide synthase (eNOS)-derived NO production. However, we have…”
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Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study by Moreira, Luciana N., Feltrin, Clarissa, Gonçalves, José E., de Castro, Whocely V., Simões, Cláudia M.O., de Pádua, Rodrigo M., Cortes, Steyner F., Braga, Fernão C.

“…[Display omitted] •An UPLC-ESI-MS/MS method was developed to quantify bornesitol in rat plasma.•Pharmacokinetic of bornesitol was evaluated after intravenous…”
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Structure and Vasorelaxant Activity of Floranol, a Flavonoid Isolated from the Roots of Dioclea grandiflora by Lemos, Virgínia S., Côrtes, Steyner F., dos Santos, Marcelo H., Ellena, Javier, Moreira, Maria E. C., Doriguetto, Antônio C.

“…The structure of the prenylated flavanonol, floranol (1=(2R,3R)‐3,5,7‐trihydroxy‐2‐(2‐hydroxyphenyl)‐6‐methoxy‐8‐(3‐methylbut‐2‐enyl)‐4H‐1‐benzopyran‐4‐one),…”
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Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid by Lemos, Virgı́nia S, Freitas, Maria Regina, Muller, Bernard, Lino, Yanna D, Queiroga, Cila E.G, Côrtes, Steyner F

“…In the present work, the vasorelaxant effect of dioclein, a new flavonoid isolated from Dioclea grandiflora (Leguminoseae), was investigated in the rat aorta…”
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Neuronal nitric oxide synthase-derived hydrogen peroxide effect in grafts used in human coronary bypass surgery by Endlich, Patrick Wander, Aires, Rosária Dias, Gonçalves, Roberta Lins, Costa, Eduardo Damasceno, de Paula Arantes Ângelo, Janaína, Alves, Lucas Ferreira, da Silva, Rafaela Fernandes, Rezende, Bruno Almeida, Cortes, Steyner F, Lemos, Virgínia Soares

“…Recently, H O has been identified as the endothelium-dependent hyperpolarizing factor (EDHF), which mediates flow-induced dilation in human coronary arteries…”
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Mechanism of endothelium-dependent vasodilation induced by a proanthocyanidin-rich fraction from Ouratea semiserrata by Côrtes, Steyner F, Valadares, Ydia M, de Oliveira, Alaíde Braga, Lemos, Virgínia S, Barbosa, Marco P T, Braga, Fernão Castro

“…The vasodilator effects of Ouratea semiserrata stem hydroethanolic extract (OSE) and its ethyl acetate fraction (OSR) were evaluated in endothelium-intact…”
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Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery by Moreira, Luciana N, Silva, Josiane F, Silva, Grazielle C, Lemos, Virgínia S, Cortes, Steyner F

“…D-pinitol is a cyclitol present in several edible plant species and extensively investigated for the treatment of metabolic diseases in humans, as food…”
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