A sensitive and selective platinum-based electrochemical sensor for detection of neurotransmitters: Design and proof of concept

[Display omitted] •Pt microparticles supported on GO/GC were designed as an electrochemical sensor.•Pt/GO/GC was used in solutions that mimic the composition of biological fluids.•This Pt/GO/GC sensor was able to quantify 9 × 10-8 mol/L of epinephrine (EP).•Pt/GO/GC shows excellent sensitivity to EP...

Full description

Saved in:

Bibliographic Details
Published in:	Microchemical journal Vol. 193; p. 109017
Main Authors:	Côrtes, Clarice, Mantilla, John C., da Silva, Sebastião W., Camara, Giuseppe A., Giz, M. Janete
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-10-2023
Subjects:	Ascorbic acid Electrochemical sensor Epinephrine Neurotransmitters Epinephrine Neurotransmitters Ascorbic acid Electrochemical sensor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Pt microparticles supported on GO/GC were designed as an electrochemical sensor.•Pt/GO/GC was used in solutions that mimic the composition of biological fluids.•This Pt/GO/GC sensor was able to quantify 9 × 10-8 mol/L of epinephrine (EP).•Pt/GO/GC shows excellent sensitivity to EP even in presence of typical interferents.•Pt/GO/GC is promising as an easy-to-build sensor to EP and other catecholamines. Monitoring the concentration of neurotransmitters in brain plays a vital role in the study and diagnosis of neurological diseases, but its sensitivity remains a challenge. In this study, a new electrochemical sensor was developed based on the modification of a glassy carbon electrode with graphene oxide and platinum microparticles (Pt/GO/GC) for simultaneous determination of epinephrine (EP), ascorbic acid (AA) and uric acid (UA). The morphology and structure of GO and Pt/GO/GC were characterized by FTIR spectroscopy, Raman spectroscopy, X-ray diffraction, scanning electron microscopy, EDS and cyclic voltammetry. Pt/GO/GC exhibits excellent catalytic activity for determining EP, AA and UA. Specifically, Pt/GO/GC separates the peak potentials for electro-oxidation of AA-EP by 190 mV and for EP-UA by 140 mV, while bare GC cannot resolve them. The simultaneous determination of these species in their mixture solution showed a wide linear response in the concentration ranges of 1–16 mM, 0.1–1.6 mM and 0.1–1.6 mM for AA, EP, and UA, respectively. In addition, the sensor was able to determine EP in the presence of different concentrations of AA and UA and it is feasible to be applied in the determination of EP in biological fluids.
ISSN:	0026-265X 1095-9149
DOI:	10.1016/j.microc.2023.109017