Search Results - "Côrrea, Arlene Gonçalves"
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Structure–activity relationship of (−) mammea A/BB derivatives against Leishmania amazonensis
Published in Biomedicine & pharmacotherapy (01-11-2008)“…Abstract To study the structure–activity relationship of coumarin (−) mammea A/BB isolated from the CH2 Cl2 extract of Calophyllum brasiliense leaves, we…”
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Advances in the Asymmetric Synthesis of BINOL Derivatives
Published in Molecules (Basel, Switzerland) (20-12-2022)“…BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis…”
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Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines
Published in Molecules (Basel, Switzerland) (11-02-2019)“…Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently…”
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A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi
Published in PloS one (17-01-2014)“…Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered…”
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Attraction of the sand fly Nyssomyia neivai (Diptera: Psychodidae) to chemical compounds in a wind tunnel
Published in Parasites & vectors (07-03-2015)“…BACKGROUND: Similar to other hematophagous insects, male and female sand flies must feed on plants to obtain sugar and, subsequently, energy to complete their…”
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laboratory evaluation of alcohols as attractants for the sandfly Lutzomyia longipalpis (Diptera:Psychodidae)
Published in Parasites & vectors (06-02-2014)“…BACKGROUND: The potential attraction from 1-octen-3-ol for sandflies has been documented; however, studies using other primary alcohols are limited. FINDINGS:…”
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Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents
Published in European journal of medicinal chemistry (27-01-2015)“…Quinoxalines belong to the N-containing heterocyclic compounds that stand out as having promising biological activity due to their privileged scaffold. In this…”
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In Vitro and In Vivo Activities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis
Published in Antimicrobial agents and chemotherapy (01-06-2016)“…Leishmaniasis is endemic in 98 countries and territories worldwide. The therapies available for leishmaniasis have serious side effects, thus prompting the…”
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Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents
Published in Bioorganic & medicinal chemistry (07-08-2018)“…[Display omitted] •Anti-Trypanosoma and anti-Leishmania activities were assessed employing HTS assays.•Methylsulfoxyl, methylsulfonyl, and diaryl quinoxalines…”
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Acetylcholinesterase capillary enzyme reactor for screening and characterization of selective inhibitors
Published in Journal of pharmaceutical and biomedical analysis (25-01-2013)“…► Acetylcholinesterase from Electric eel was immobilized onto a fused silica capillary resulting AChE-ICER. ► AChE-ICER was employed as an LC biochromatography…”
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Journal Article Conference Proceeding -
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Immobilized cholinesterases capillary reactors on-flow screening of selective inhibitors
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-10-2014)“…•Butyrylcholinesterase from human serum was immobilized onto a fused silica capillary.•BChE-ICER was employed in an LC/UV system in on line inhibitor…”
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Antileishmanial activity of amides from Piper amalago and synthetic analogs
Published in Revista brasileira de farmacognosia (01-05-2013)“…Two natural amides isolated from the chloroform extract of Piper amalago L., Piperaceae, leaves, a hydrogenated derivative and seven synthetic analogs were…”
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Liposome-based nanocarrier loaded with a new quinoxaline derivative for the treatment of cutaneous leishmaniasis
Published in Materials Science & Engineering C (01-05-2020)“…The use of nanocarriers for drug delivery is a strategy aimed to improve therapeutic indices through changes in their pharmacokinetic and pharmacodynamic…”
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QSAR-3D e Docking Molecular de Derivados de Acidos N-arilantranilicos com Atividade Inibitoria na Enzima Catepsina L
Published in Orbital : The Electronic Journal of Chemistry (01-02-2016)“…In this work, a molecular modeling study of N-arylanthranilic acid derivatives with inhibitory action on the Cathepsin L enzyme in presented. Firstly, a 3DQSAR…”
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Asymmetric organocatalyzed synthesis of coumarin derivatives
Published in Beilstein journal of organic chemistry (2021)“…Coumarin derivatives are essential scaffolds in medicinal and synthetic chemistry. Compounds of this class have shown important activities, such as anticancer…”
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QSAR-3D e Docking Molecular de Derivados de Ácidos N-arilantranílicos com Atividade Inibitória na Enzima Catepsina L
Published in Orbital : The Electronic Journal of Chemistry (01-02-2016)“…In this work, a molecular modeling study of N-arylanthranilic acid derivatives with inhibitory action on the Cathepsin L enzyme in presented. Firstly, a 3DQSAR…”
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Journal Article -
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QSAR-3D e Docking Molecular de Derivados de Ácidos N-arilantranílicos com Atividade Inibitória na Enzima Catepsina L
Published in Orbital : The Electronic Journal of Chemistry (18-02-2016)Get full text
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A Quinoxaline Derivative as a Potent Chemotherapeutic Agent, Alone or in Combination with Benznidazole, against Trypanosoma cruzi: e85706
Published in PloS one (01-01-2014)“…Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is…”
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