Search Results - "Cáceres, F J"

The dynamics of a pre-mRNA splicing factor in living cells by Misteli, Tom, Cáceres, Javier F, Spector, David L

“…Pre-mRNA splicing is a predominantly co-transcriptional event which involves a large number of essential splicing factors. Within the mammalian cell nucleus,…”
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Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors by Cáceres, Javier F., Stamm, Stefan, Helfman, David M., Krainer, Adrian R.

“…The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP) A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1…”
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Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1 by Eperon, Ian C., Makarova, Olga V., Mayeda, Akila, Munroe, Stephen H., Cáceres, Javier F., Hayward, Daniel G., Krainer, Adrian R.

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Coupling of Transcription with Alternative Splicing: RNA Pol II Promoters Modulate SF2/ASF and 9G8 Effects on an Exonic Splicing Enhancer by Cramer, Paula, Cáceres, Javier F, Cazalla, Demián, Kadener, Sebastián, Muro, Andrés F, Baralle, Francisco E, Kornblihtt, Alberto R

“…Alternative mRNA splicing of the fibronectin EDI exon is controlled by a purine-rich exonic splicing enhancer (ESE), postulated as a binding site for SR…”
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Identification and characterization of three members of the human SR family of pre‐mRNA splicing factors by Screaton, G. R., Cáceres, J. F., Mayeda, A., Bell, M. V., Plebanski, M., Jackson, D. G., Bell, J. I., Krainer, A. R.

“…SR proteins have a characteristic C‐terminal Ser/Arg‐rich repeat (RS domain) of variable length and constitute a family of highly conserved nuclear…”
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Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors by HANAMURA, AKEMI, CÁCERES, JAVIER F., MAYEDA, AKILA, FRANZA Jr, B. ROBERT, KRAINER, ADRIAN R.

“…The SR proteins are essential metazoan pre-mRNA splicing factors that can also influence the selection of alternative 5′ splice sites in a…”
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Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity by Cáceres, Javier F., Misteli, Tom, Screaton, Gavin R., Spector, David L., Krainer, Adrian R.

“…SR proteins are required for constitutive pre-mRNA splicing and also regulate alternative splice site selection in a concentration-dependent manner. They have…”
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Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription in vivo by Misteli, Tom, Cáceres, Javier F., Clement, Jade Q., Krainer, Adrian R., Wilkinson, Miles F., Spector, David L.

“…Expression of most RNA polymerase II transcripts requires the coordinated execution of transcription, splicing, and 3′ processing. We have previously shown…”
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Functional characterization of SR and SR-related genes in Caenorhabditis elegans by Longman, Dása, Johnstone, Iain L., Cáceres, Javier F.

“…The SR proteins constitute a family of nuclear phosphoproteins, which are required for constitutive splicing and also influence alternative splicing…”
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Large-scale identification of mammalian proteins localized to nuclear sub-compartments by SUTHERLAND, Heidi G. E, MUMFORD, Gail K, NEWTON, Kathryn, FORD, Lisa V, FARRALL, Rachel, DELLAIRE, Graham, CACERES, Javier F, BICKMORE, Wendy A

“…Many nuclear components participating in related pathways appear concentrated in specific areas of the mammalian nucleus. The importance of this organization…”
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Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing by Cowper, Alison E., Cáceres, Javier F., Mayeda, Akila, Screaton, Gavin R.

“…We have characterized two RNA-binding proteins, of apparent molecular masses of ∼40 and 35 kDa, which possess a single N-terminal RNA-recognition motif (RRM)…”
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Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins by Mayeda, A., Munroe, S.H., Cáceres, J.F., Krainer, A.R.

“…hnRNP A1 is a pre‐mRNA binding protein that antagonizes the alternative splicing activity of splicing factors SF2/ASF or SC35, causing activation of distal 5′…”
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SRPK1 and Clk/Sty Protein Kinases Show Distinct Substrate Specificities for Serine/Arginine-rich Splicing Factors by Colwill, K, Feng, L L, Yeakley, J M, Gish, G D, Cáceres, J F, Pawson, T, Fu, X D

“…Serine/arginine-rich (SR) proteins are essential for pre-mRNA splicing, and modify the choice of splice site during alternative splicing in a process…”
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Distinctive Features of Drosophila Alternative Splicing Factor RS Domain: Implication for Specific Phosphorylation, Shuttling, and Splicing Activation by Allemand, Eric, Gattoni, Renata, Bourbon, Henri-Marc, Stevenin, James, Cáceres, Javier F., Soret, Johann, Tazi, Jamal

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Multiple roles of arginine/serine-rich splicing factors in RNA processing by Sanford, J R, Ellis, J, Cáceres, J F

“…SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their…”
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Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans by Longman, Dáša, McGarvey, Tim, McCracken, Susan, Johnstone, Iain L., Blencowe, Benjamin J., Cáceres, Javier F.

“…Background: SR family and SR-related proteins assemble on exonic splicing enhancer (ESE) sequences to promote both constitutive and regulated splicing. The…”
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Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta by Balasubramanian, M, Hurst, J, Brown, S, Bishop, N.J, Arundel, P, DeVile, C, Pollitt, R.C, Crooks, L, Longman, D, Caceres, J.F, Shackley, F, Connolly, S, Payne, J.H, Offiah, A.C, Hughes, D, Parker, M.J, Hide, W, Skerry, T

“…Abstract Background Osteogenesis imperfecta (OI), the commonest inherited bone fragility disorder, affects 1 in 15,000 live births resulting in frequent…”
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Role of SR protein modular domains in alternative splicing specificity in vivo by van Der Houven Van Oordt, W, Newton, K, Screaton, G R, Cáceres, J F

“…The SR proteins constitute a family of nuclear phosphoproteins which are required for constitutive splicing and also influence alternative splicing regulation…”
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Control of mouse U1a and U1b snRNA gene expression by differential transcription by Cáceres, Javier F., McKenzie, Debbie, Thimmapayau, Rama, Lund, Elsebet, Dahlberg, James E.

“…The expression of mouse embryonic U1 snRNA (mU1b) genes is subject to stage- and tissue-specific control, being restricted to early embryos and adult tissues…”
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Multiple roles of the SR protein family in splicing regulation by Sanford, J R, Longman, D, Cáceres, J F

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