Search Results - "Bzura, Aleksandra"

Evaluating niraparib versus active symptom control in patients with previously treated mesothelioma (NERO): a study protocol for a multicentre, randomised, two-arm, open-label phase II trial in UK secondary care centres by Fennell, Dean, Griffiths, Daniel, Eminton, Zina, Morgan-Fox, Abigail, Hill, Kayleigh, Ewings, Sean, Stuart, Charlotte, Johnson, Lucy, Mallard, Kim, Nye, Mavis, Darlison, Liz, Dulloo, Sean, Cave, Judith, Luo, Jin-Li, Taylor, Paul, Spicer, Jake, Poile, Charlotte, Bzura, Aleksandra, Griffiths, Gareth

“…BackgroundMalignant mesothelioma is a rapidly lethal cancer that has been increasing at an epidemic rate over the last three decades. Targeted therapies for…”
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CD40L/IL-4–stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM by Lezina, Larissa, Spriggs, Ruth V., Beck, Daniel, Jones, Carolyn, Dudek, Kate M., Bzura, Aleksandra, Jones, George D.D., Packham, Graham, Willis, Anne E., Wagner, Simon D.

“…CD40L/interleukin-4 (IL-4) stimulation occurs in vivo in the tumor microenvironment and induces global translation to varying degrees in individuals with…”
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Precision Therapy for Mesothelioma: Feasibility and New Opportunities by Dulloo, Sean, Bzura, Aleksandra, Fennell, Dean Anthony

“…Malignant pleural mesotheliomas (MPMs) are characterised by their wide variation in natural history, ranging from minimally to highly aggressive, associated…”
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Targeting DNA Damage Response Deficiency in Thoracic Cancers by Bzura, Aleksandra, Spicer, Jake B., Dulloo, Sean, Yap, Timothy A., Fennell, Dean A.

“…Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM). Collectively, they…”
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61 The first-in-class peroxiredoxin 3 (PRX3) inhibitor RSO-021 modulates the mesenchymal and immune phenotype in mesothelioma by Cunniff, Brian, Messier, Terri, Gibson, Victoria, Seward, David, Baitei, Essa, Wells Jordan, Peter, Poile, Charlotte, Dzialo, Joanna, Bzura, Aleksandra, Kutywayo, Kudzayi, Nakas, Apostolos, Naumov, George, Fennell, Dean

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A gut microbiota rheostat to forecast response to PDL1-VEGF blockade in mesothelioma by Fennell, Dean Anthony, Bzura, Aleksandra, Branson, Amy, King, Amy, Rogel, Jan, Barber, Shaun, Poile, Charlotte, Harber, James, Zhou, Zisen, Pritchard, Catrin, Kamata, Tamihiro, Wells-Jordan, Peter, Nusrat, Nada, Baitei, Essa, Dzialo, Joanna, Thomas, Anne, Barer, Michael, Haldar, Kairobi, Zhang, Min

“…e20534 Background: Targeting of the immune inhibitory PD1-PDL1 axis has proven clinically effective in mesothelioma, despite a low somatic mutation burden, and…”
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Accelerating innovations in systemic therapy for pleural mesothelioma by Fennell, Dean A., Bzura, Aleksandra

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BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms by Singh, Anita, Busacca, Sara, Gaba, Aarti, Sheaff, Michael, Poile, Charlotte, Nakas, Apostolos, Dzialo, Joanna, Bzura, Aleksandra, Dawson, Alan G., Fennell, Dean A., Fry, Andrew M.

“…The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for BAP1 in…”
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ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance by Mellone, Massimiliano, Piotrowska, Klaudia, Venturi, Giulia, James, Lija, Bzura, Aleksandra, Lopez, Maria A, James, Sonya, Wang, Chuan, Ellis, Matthew J, Hanley, Christopher J, Buckingham, Josephine F, Cox, Kerry L, Hughes, Gareth, Valge-Archer, Viia, King, Emma V, Beers, Stephen A, Jaquet, Vincent, Jones, George D D, Savelyeva, Natalia, Sayan, Emre, Parsons, Jason L, Durant, Stephen, Thomas, Gareth J

“…Myofibroblastic cancer-associated fibroblast (myoCAF)-rich tumors generally contain few T cells and respond poorly to immune-checkpoint blockade. Although…”
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Family Matters: Germline Testing in Thoracic Cancers by Hathaway, Feighanne, Martins, Renato, Sorscher, Steven, Bzura, Aleksandra, Dudbridge, Frank, Fennell, Dean A

“…Most thoracic cancers arise via a series of stepwise somatic alterations driven by a well-defined carcinogen (ie, tobacco or asbestos for lung cancer and…”
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193 - Niraparib efficacy in patients with unresectable mesothelioma: a randomised phase II trial of niraparib versus active symptom control in patients with previously treated mesothelioma: NERO (TRIALS IN PROGRESS) by Fennell, Dean, Griffiths, Daniel, Eminton, Zina, Morgan-Fox, Abigail, Hill, Kayleigh, Nearchou, Theodora, Johnson, Lucy, Harding, Stephanie, Poile, Charlotte, Bzura, Aleksandra, Spicer, Jake, Nye, Mavis, Cave, Judith, Danson, Sarah, Toy, Elizabeth, Jain, Pooja, Steele, Nicola, Shaw, Paul, Taylor, Paul, Szlosarek, Peter, Papadatos-Pastos, Dionysis, Lind, Michael, Dulloo, Sean, Saman, Harman, Bajaj, Amrita, Luo, Jin-Li, Darlison, Liz, Griffiths, Gareth

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Niraparib efficacy in patients with unresectable mesothelioma: a randomised phase II trial of niraparib versus active symptom control in patients with previously treated mesothelioma: NERO (TRIALS IN PROGRESS) by Fennell, Dean, Griffiths, Daniel, Eminton, Zina, Morgan-Fox, Abigail, Hill, Kayleigh, Nearchou, Theodora, Johnson, Lucy, Harding, Stephanie, Poile, Charlotte, Bzura, Aleksandra, Spicer, Jake, Nye, Mavis, Cave, Judith, Danson, Sarah, Toy, Elizabeth, Jain, Pooja, Steele, Nicola, Shaw, Paul, Taylor, Paul, Szlosarek, Peter, Papadatos-Pastos, Dionysis, Lind, Michael, Dulloo, Sean, Saman, Harman, Bajaj, Amrita, Luo, Jin-Li, Darlison, Liz, Griffiths, Gareth

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Abstract 384: SLC7A11 modulates sensitivity to the first-in-class mitochondrial peroxiredoxin 3 inhibitor thiostrepton (RSO-021) via a ferroptosis independent pathway by Messier, Terri, Gibson, Victoria, Bzura, Aleksandra, Dzialo, Joanna, Poile, Charlotte, Stead, Stephanie, Saaman, Alexis, Naumov, George N., Fennell, Dean A., Cunniff, Brian

“…Abstract Mitochondrial peroxiredoxin 3 (PRX3) has been identified as an actionable cancer vulnerability that is currently being investigated in the…”
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Abstract 666: ASTX295 engages p53-mediated apoptosis and an inflammatory response in patient derived mesothelioma explants by Fennell, Dean Anthony, Dzialo, Joanna, Rogel, Jan, Faulkner, Daniel, Nusrat, Nada, Bzura, Aleksandra, Kutywayo, Kudzayi, Wells-Jordan, Peter, Poile, Charlotte, Biondo, Andrea, Sims, Martin, Nakas, Apostolos, Luo, Jin-Li, Zhang, Min, Ahn, Maria

“…Abstract Mesothelioma is a universally lethal, rare cancer caused by asbestos that is lacking effective targeted treatments, particularly in the relapsed…”
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Abstract 4716: First-in-class peroxiredoxin 3 (PRX3) inhibitor RSO-021 triggers mesenchymal-to-epithelial transition in mesothelioma by Messier, Terri, Gibson, Victoria, Seward, David J., Baitei, Essa Y., Jordan, Peter Wells, Poile, Charlotte, Dzialo, Joanna, Bzura, Aleksandra, Kutywayo, Kudzayi, Nakas, Apostolos, Naumov, George N., Fennell, Dean A., Cunniff, Brian

“…Abstract Mesothelioma, a lethal cancer associated with asbestos exposure, lacks effective drug therapy particularly in the relapsed treatment setting…”
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Abstract 6086: Clonal biallelic inactivation of NF2 is an evolutionary bottleneck that exposes a vulnerability to CDK7 inhibition in mesothelioma by Baitei, Essa Y., Zhang, Min, Sun, Qianqian, Luo, Jin-Li, Zhang, Philip, Kamata, Tamihiro, Harber, James, Bzura, Aleksandra, Jordan, Peter W., Poile, Charlotte, Dawson, Alan, Nakas, Apostolos, Richards, Cathy, Yang, Hongji, Hollox, Ed, Fennell, Dean A.

“…Abstract Background: Mesothelioma, a cancer caused by asbestos is lethal and lacks molecularly targeted therapy. The tumor suppressor NF2 constitutes a…”
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Abstract 1613: Systematic screening for genomic vulnerabilities as drug targets for mesothelioma by Griffiths, Gareth J., James, Dominic I., Dyson, Beth, Nalubowa, Immaculate M., Nakas, Apostolos, Baas, Paul, Tabi, Zsuzsanna, Zhang, Min, Sun, Qianqian, Faulkner, Daniel, Nusrat, Nada, Baitei, Essa Y., Dzialo, Joanna, Dawson, Alan, Poile, Charlotte, Spicer, Jake, Bzura, Aleksandra, Luo, Jin-Li, Yang, Hongji, Richards, Cathy, Fennell, Dean A.

“…Abstract Mesothelioma is a rare, lethal cancer caused by asbestos. Despite recent advances molecularly stratified therapy is lacking, in part due to the…”
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