The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract

The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract

Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoti...

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Published in:Evidence-based complementary and alternative medicine Vol. 2016; no. 2016; pp. 1 - 10
Main Authors: Noh, Byung Seung, Heo, Jeong-Doo, Kim, Euikyung, Kang, Changkeun, Byun, Jae Kuk, Kwon, Young Chul, Choudhary, Indu, Heo, Yunwi, Bae, Seong Kyeong, Yang, Hyeryeon, Kim, Na-Hyun, Lee, Hyunkyoung, Yim, Hyeong Jun
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2016
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Analysis
Growth
Hair loss
Immunohistochemistry
Kinases
Medical research
Medicine, Botanic
Medicine, Herbal
Mice
Proteins
Skin
Skin diseases
Studies
South Korea
Japan
United States > US
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Summary:Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.
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Academic Editor: Yoshiyuki Kimura
ISSN:1741-427X
1741-4288
DOI:10.1155/2016/1873746