Search Results - "Bystrykh, V V"

Generalized DNA barcode design based on Hamming codes by Bystrykh, Leonid V

“…The diversity and scope of multiplex parallel sequencing applications is steadily increasing. Critically, multiplex parallel sequencing applications methods…”
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Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding by Verovskaya, Evgenia, Broekhuis, Mathilde J.C., Zwart, Erik, Ritsema, Martha, van Os, Ronald, de Haan, Gerald, Bystrykh, Leonid V.

“…The number of hematopoietic stem cells (HSCs) that contributes to blood formation and the dynamics of their clonal contribution is a matter of ongoing…”
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Cellular barcoding tool for clonal analysis in the hematopoietic system by Gerrits, Alice, Dykstra, Brad, Kalmykowa, Olga J., Klauke, Karin, Verovskaya, Evgenia, Broekhuis, Mathilde J.C., de Haan, Gerald, Bystrykh, Leonid V.

“…Clonal analysis is important for many areas of hematopoietic stem cell research, including in vitro cell expansion, gene therapy, and cancer progression and…”
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Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding by Belderbos, Mirjam E., Koster, Taco, Ausema, Bertien, Jacobs, Sabrina, Sowdagar, Sharlaine, Zwart, Erik, de Bont, Eveline, de Haan, Gerald, Bystrykh, Leonid V.

“…Genetic and phenotypic heterogeneity of human leukemia is thought to drive leukemia progression through a Darwinian process of selection and evolution of…”
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Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity by Kim, Kyung Mok, Mura-Meszaros, Anna, Tollot, Marie, Krishnan, Murali Shyam, Gründl, Marco, Neubert, Laura, Groth, Marco, Rodriguez-Fraticelli, Alejo, Svendsen, Arthur Flohr, Campaner, Stefano, Andreas, Nico, Kamradt, Thomas, Hoffmann, Steve, Camargo, Fernando D., Heidel, Florian H., Bystrykh, Leonid V., de Haan, Gerald, von Eyss, Björn

“…Specific functions of the immune system are essential to protect us from infections caused by pathogens such as viruses and bacteria. However, as we age, the…”
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The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion by Kamminga, Leonie M., Bystrykh, Leonid V., de Boer, Aletta, Houwer, Sita, Douma, José, Weersing, Ellen, Dontje, Bert, de Haan, Gerald

“…The molecular mechanism responsible for a decline of stem cell functioning after replicative stress remains unknown. We used mouse embryonic fibroblasts (MEFs)…”
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Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells by Gerrits, Alice, Walasek, Marta A., Olthof, Sandra, Weersing, Ellen, Ritsema, Martha, Zwart, Erik, van Os, Ronald, Bystrykh, Leonid V., de Haan, Gerald

“…Hematopoietic stem/progenitor cell (HSPC) traits differ between genetically distinct mouse strains. For example, DBA/2 mice have a higher HSPC frequency…”
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Expression quantitative trait loci are highly sensitive to cellular differentiation state by Gerrits, Alice, Li, Yang, Tesson, Bruno M, Bystrykh, Leonid V, Weersing, Ellen, Ausema, Albertina, Dontje, Bert, Wang, Xusheng, Breitling, Rainer, Jansen, Ritsert C, de Haan, Gerald

“…Genetical genomics is a strategy for mapping gene expression variation to expression quantitative trait loci (eQTLs). We performed a genetical genomics…”
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Measures of Clonal Hematopoiesis: Are We Missing Something? by Bystrykh, Leonid V, Belderbos, Mirjam E

“…Clonal Hematopoiesis (CH) is a common, age-related phenomenon of growing scientific interest, due to its association with hematologic malignancy,…”
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Genetical genomics: spotlight on QTL hotspots by Breitling, Rainer, Li, Yang, Tesson, Bruno M, Fu, Jingyuan, Wu, Chunlei, Wiltshire, Tim, Gerrits, Alice, Bystrykh, Leonid V, de Haan, Gerald, Su, Andrew I, Jansen, Ritsert C

“…  [...]a key consideration in eQTL analysis is in the effective design of a permutation strategy to assess statistical significance. [...]the number of…”
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CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions by Jung, Johannes, Buisman, Sonja C., Weersing, Ellen, Dethmers-Ausema, Albertina, Zwart, Erik, Schepers, Hein, Dekker, Mike R., Lazare, Seka S., Hammerl, Franziska, Skokova, Yulia, Kooistra, Susanne M., Klauke, Karin, Poot, Raymond A., Bystrykh, Leonid V., de Haan, Gerald

“…In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem…”
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Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion by Wojtowicz, Edyta E, Mistry, Jayna J, Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W, Kettyle, Laura M, Grasso, Francesca, Lord, Allegra M, Wright, David J, Etherington, Graham J, Woll, Petter S, Belderbos, Mirjam E, Bowles, Kristian M, Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V, Jacobsen, Sten Eirik W, Rushworth, Stuart A, Macaulay, Iain C

“…Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages…”
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No Monkeying Around: Clonal Tracking of Stem Cells and Progenitors in the Macaque by Dykstra, Brad, Bystrykh, Leonid V.

“…Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell,…”
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Barcoded vector libraries and retroviral or lentiviral barcoding of hematopoietic stem cells by Bystrykh, Leonid V, de Haan, Gerald, Verovskaya, Evgenia

“…Cellular barcoding is a relatively recent technique aimed at clonal analysis of a proliferating cell population of any kind. The method was shown to be…”
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Why an integrated view of gene expression studies on hematopoiesis in mouse aging is better than the sum of their parts by Bystrykh, Leonid V

“…Globally, the human population is aging, with an increased proportion of people in "old age" (over 60 years). This trend leads to a growing demand in aging…”
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Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus by Brugman, Martijn H., Wiekmeijer, Anna-Sophia, van Eggermond, Marja, Wolvers-Tettero, Ingrid, Langerak, Anton W., de Haas, Edwin F. E., Bystrykh, Leonid V., van Rood, Jon J., de Haan, Gerald, Fibbe, Willem E., Staal, Frank J. T.

“…The fate and numbers of hematopoietic stem cells (HSC) and their progeny that seed the thymus constitute a fundamental question with important clinical…”
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In Vitro Generation of Long-Term Repopulating Hematopoietic Stem Cells by Fibroblast Growth Factor-1 by de Haan, Gerald, Weersing, Ellen, Dontje, Bert, van Os, Ronald, Bystrykh, Leonid V., Vellenga, Edo, Miller, Geraldine

“…The role of fibroblast growth factors and their receptors (FGFRs) in the regulation of normal hematopoietic stem cells is unknown. Here we show that, in mouse…”
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Levenshtein error-correcting barcodes for multiplexed DNA sequencing by Buschmann, Tilo, Bystrykh, Leonid V

“…High-throughput sequencing technologies are improving in quality, capacity and costs, providing versatile applications in DNA and RNA research. For small…”
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Minimizing of Renewable Energy Sources Impact on the Energy System Operation by the Joint Use of Solar and Wind Generation by V. A. Liubchyk, S. V. Bystrykh, A. N. Kazak

“…The purpose of the study was to test the hypothesis of the existence of an optimal ratio of the installed capacity of solar and wind power plants, which…”
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Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding by Klauke, Karin, Broekhuis, Mathilde J C, Weersing, Ellen, Dethmers-Ausema, Albertina, Ritsema, Martha, González, Marta Vilà, Zwart, Erik, Bystrykh, Leonid V, de Haan, Gerald

“…Accurate monitoring of tumor dynamics and leukemic stem cell (LSC) heterogeneity is important for the development of personalized cancer therapies. In this…”
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