Search Results - "Byrum, Jennifer"

RAG2 localization and dynamics in the pre-B cell nucleus by Rodgers, William, Byrum, Jennifer N, Simpson, Destiny A, Hoolehan, Walker, Rodgers, Karla K

“…RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the…”
Get full text

An updated definition of V(D)J recombination signal sequences revealed by high-throughput recombination assays by Hoolehan, Walker, Harris, Justin C, Byrum, Jennifer N, Simpson, Destiny A, Rodgers, Karla K

“…In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination…”
Get full text

Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye by Summers, Jody A., Harper, Angelica R., Feasley, Christa L., Van-Der-Wel, Hanke, Byrum, Jennifer N., Hermann, Marcela, West, Christopher M.

“…All-trans-retinoic acid may be an important molecular signal in the postnatal control of eye size. The goal of this study was to identify retinoic acid-binding…”
Get full text

Full length RAG2 expression enhances the DNA damage response in pre-B cells by Byrum, Jennifer N., Hoolehan, Walker E., Simpson, Destiny A., Rodgers, William, Rodgers, Karla K.

“…V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export…”
Get full text

Membrane-cytoskeleton interactions in cholesterol-dependent domain formation by Byrum, Jennifer N, Rodgers, William

“…Since the inception of the fluid mosaic model, cell membranes have come to be recognized as heterogeneous structures composed of discrete protein and lipid…”
Get more information

Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations by Demirdjian, Sally, Duong, Vincent N., Byrum, Jennifer N., Nayak, Arabinda, McKinney, Cooper B., Perry, Jason K., Callebaut, Christian, Rodgers, Karla K., Falkard, Brie, Feng, Joy Y.

“…Human immunodeficiency virus 1 (HIV-1) infection remains a global health concern, with nearly 30 million people on antiretroviral (ARV) treatment. Integrase…”
Get full text

CD28 sensitizes TCR Ca²⁺ signaling during Ag-independent polarization of plasma membrane rafts by Byrum, Jennifer N, Van Komen, Jeffrey S, Rodgers, William

“…T cells become polarized during initial interactions with an APC to form an Ag-independent synapse (AIS) composed of membrane rafts, TCR, and TCR-proximal…”
Get full text

An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex by Byrum, Jennifer N, Zhao, Shuying, Rahman, Negar S, Gwyn, Lori M, Rodgers, William, Rodgers, Karla K

“…V(D)J recombination assembles functional antigen receptor genes during lymphocyte development. Formation of the recombination complex containing the…”
Get full text

Spatio-temporal regulation of RAG2 following genotoxic stress by Rodgers, William, Byrum, Jennifer N., Sapkota, Hem, Rahman, Negar S., Cail, Robert C., Zhao, Shuying, Schatz, David G., Rodgers, Karla K.

“…•Genotoxic stress triggers nuclear export and centrosome targeting of RAG2.•Inhibitors to DNA damage response factors blocked redistribution of RAG2.•Following…”
Get full text

RAG2 interactions with H3K4me3 are regulated by Thr490 proximal to the RAG2 PHD region by Rodgers, William A., Byrum, Jennifer, Rodgers, Karla

“…Abstract Association of RAG2 with the epigenetic marker H3K4me3 through a plant homeodomain (PHD) in the RAG2 non core domain is important for relieving auto…”
Get full text

Full Length RAG2 Expression Enhances the DNA Damage Response in Pre-B Cells by Byrum, Jennifer, Rodgers, William A., Rodgers, Karla

“…Abstract V(D)J recombination of lymphocyte antigen receptor genes occurs via formation of DNA double strand breaks (DSBs) through activity of RAG1 and RAG2…”
Get full text

Elucidating regulatory mechanisms of RAG2 in response to DNA damage by Byrum, Jennifer, Rodgers, William, Rodgers, Karla

“…Abstract V(D)J recombination of lymphocyte antigen receptor genes occurs via the formation of DNA double strand breaks (DSBs) through the activity of RAG1 and…”
Get full text

Visualization of binding of RAG2 to H3K4me3 regulated by its noncore domain by Rodgers, William A, Byrum, Jennifer, Rodgers, Karla K

“…Abstract Association of RAG2 with the epigenetic marker H3K4me3 through a PHD domain in its noncore region is important for activating the RAG1 component of…”
Get full text

Modulation of RAG2 Interactions With Histone H3K4me3 Through Residue Thr490 by Rodgers, William A, Byrum, Jennifer, Simpson, Destiny, Hoolehan, Walker, Rodgers, Karla

“…Abstract RAG2 is essential for V(D)J recombination in developing lymphocytes, yet its localization and dynamics in cell nuclei is poorly understood. Here, we…”
Get full text

CD28 Sensitizes TCR Ca2+ Signaling During Ag-Independent Polarization of Plasma Membrane Raftsi by Byrum, Jennifer N., Van Komen, Jeffrey S., Rodgers, William

“…T cells become polarized during initial interactions with an APC to form an antigen-independent synapse (AIS) composed of membrane rafts, TCR, and TCR-proximal…”
Get full text

T cell raft clustering during T cell surveying of APCs requires CD28 (35.2) by Van Komen, Jeffrey S, Mishra, Sudha, Byrum, Jennifer, Rodgers, William

“…Abstract T cell activation requires the orchestrated restructuring of its plasma membrane rafts to form the immunological synapse (IS). Our published data show…”
Get full text

Visualization of inositol phosphate‐dependent mobility of Ku: depletion of the DNA–PK cofactor InsP6 inhibits Ku mobility by Byrum, Jennifer, Jordan, Stephen, Safrany, Stephen T., Rodgers, William

“…Repair of DNA double‐strand breaks (DSBs) in mammalian cells by nonhomologous end‐joining (NHEJ) is initiated by the DNA–PK protein complex. Recent studies…”
Get full text

Early and Dynamic Polarization of T Cell Membrane Rafts and Constituents Prior to TCR Stop Signals by Van Komen, Jeffrey S, Mishra, Sudha, Byrum, Jennifer, Chichili, Gurunadh R, Yaciuk, Jane C, Farris, A. Darise, Rodgers, William

“…Polarization of membrane rafts and signaling proteins to form an immunological synapse is a hallmark of T cell stimulation. However, the kinetics of raft…”
Get full text

Cytoskeleton-dependent raft clustering during T cell surveying by Byrum, Jennifer Nicole

Get full text

Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP sub(6) inhibits Ku mobility by Byrum, Jennifer, Jordan, Stephen, Safrany, Stephen T, Rodgers, William

“…Repair of DNA double-strand breaks (DSBs) in mammalian cells by nonhomologous end-joining (NHEJ) is initiated by the DNA-PK protein complex. Recent studies…”
Get full text