Search Results - "Byrnes, James R"

Red blood cells in thrombosis by Byrnes, James R., Wolberg, Alisa S.

“…Red blood cells (RBCs) have historically been considered passive bystanders in thrombosis. However, clinical and epidemiological studies have associated…”
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A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice by Miszta, Adam, Kopec, Anna K., Pant, Asmita, Holle, Lori A., Byrnes, James R., Lawrence, Daniel A., Hansen, Kirk C., Flick, Matthew J., Luyendyk, James P., de Laat, Bas, Wolberg, Alisa S.

“…Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and…”
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Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells by Kirkemo, Lisa L, Elledge, Susanna K, Yang, Jiuling, Byrnes, James R, Glasgow, Jeff E, Blelloch, Robert, Wells, James A

“…Characterization of cell surface proteome differences between cancer and healthy cells is a valuable approach for the identification of novel diagnostic and…”
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Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding by Byrnes, James R, Zhou, Xin X, Lui, Irene, Elledge, Susanna K, Glasgow, Jeff E, Lim, Shion A, Loudermilk, Rita P, Chiu, Charles Y, Wang, Taia T, Wilson, Michael R, Leung, Kevin K, Wells, James A

“…As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, there is an urgent need for new assay formats to…”
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Fibrinogen and Fibrin in Hemostasis and Thrombosis by Kattula, Sravya, Byrnes, James R, Wolberg, Alisa S

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ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens by Zamecnik, Colin R., Rajan, Jayant V., Yamauchi, Kevin A., Mann, Sabrina A., Loudermilk, Rita P., Sowa, Gavin M., Zorn, Kelsey C., Alvarenga, Bonny D., Gaebler, Christian, Caskey, Marina, Stone, Mars, Norris, Philip J., Gu, Wei, Chiu, Charles Y., Ng, Dianna, Byrnes, James R., Zhou, Xin X., Wells, James A., Robbiani, Davide F., Nussenzweig, Michel C., DeRisi, Joseph L., Wilson, Michael R.

“…Comprehensive understanding of the serological response to SARS-CoV-2 infection is important for both pathophysiologic insight and diagnostic development…”
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Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice by Kattula, Sravya, Byrnes, James R., Martin, Sara M., Holle, Lori A., Cooley, Brian C., Flick, Matthew J., Wolberg, Alisa S.

“…The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo…”
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Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells by Bartholow, Thomas G., Burroughs, Paul W.W., Elledge, Susanna K., Byrnes, James R., Kirkemo, Lisa L., Garda, Virginia, Leung, Kevin K., Wells, James A.

“…The cell surface proteome (surfaceome) plays a pivotal role in virtually all extracellular biology, and yet we are only beginning to understand the protein…”
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Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins by Pance, Katarina, Gramespacher, Josef A., Byrnes, James R., Salangsang, Fernando, Serrano, Juan-Antonio C., Cotton, Adam D., Steri, Veronica, Wells, James A.

“…Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these…”
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Mapping proteolytic neo-N termini at the surface of living cells by Weeks, Amy M., Byrnes, James R., Lui, Irene, Wells, James A.

“…N terminomics is a powerful strategy for profiling proteolytic neo-N termini, but its application to cell surface proteolysis has been limited by the low…”
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Newly-Recognized Roles of Factor XIII in Thrombosis by Byrnes, James R, Wolberg, Alisa S

“…Arterial and venous thromboses are major contributors to coagulation-associated morbidity and mortality. Greater understanding of mechanisms leading to…”
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Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection by Elledge, Susanna K., Zhou, Xin X., Byrnes, James R., Martinko, Alexander J., Lui, Irene, Pance, Katarina, Lim, Shion A., Glasgow, Jeff E., Glasgow, Anum A., Turcios, Keirstinne, Iyer, Nikita S., Torres, Leonel, Peluso, Michael J., Henrich, Timothy J., Wang, Taia T., Tato, Cristina M., Leung, Kevin K., Greenhouse, Bryan, Wells, James A.

“…Current serology tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies mainly take the form of enzyme-linked immunosorbent assays,…”
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Fibrinogen and red blood cells in venous thrombosis by Aleman, Maria M, Walton, Bethany L, Byrnes, James R, Wolberg, Alisa S

“…Abstract Deep vein thrombosis and pulmonary embolism, collectively termed venous thromboembolism (VTE), affect over 1 million Americans each year. VTE is…”
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Factor XIII activity mediates red blood cell retention in venous thrombi by Aleman, Maria M, Byrnes, James R, Wang, Jian-Guo, Tran, Reginald, Lam, Wilbur A, Di Paola, Jorge, Mackman, Nigel, Degen, Jay L, Flick, Matthew J, Wolberg, Alisa S

“…Venous thrombi, fibrin- and rbc-rich clots triggered by inflammation and blood stasis, underlie devastating, and sometimes fatal, occlusive events. During…”
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Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression by Byrnes, James R., Weeks, Amy M., Shifrut, Eric, Carnevale, Julia, Kirkemo, Lisa, Ashworth, Alan, Marson, Alexander, Wells, James A.

“…Immunosuppressive factors in the tumor microenvironment (TME) impair T cell function and limit the antitumor immune response. T cell surface receptors and…”
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Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking by Byrnes, James R., Duval, Cédric, Wang, Yiming, Hansen, Caroline E., Ahn, Byungwook, Mooberry, Micah J., Clark, Martha A., Johnsen, Jill M., Lord, Susan T., Lam, Wilbur A., Meijers, JoostC.M., Ni, Heyu, Ariëns, RobertA.S., Wolberg, Alisa S.

“…Factor XIII(a) [FXIII(a)] stabilizes clots and increases resistance to fibrinolysis and mechanical disruption. FXIIIa also mediates red blood cell (RBC)…”
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New findings on venous thrombogenesis by Byrnes, James R, Wolberg, Alisa S

“…Venous thrombosis (VT) is the third most common cause of cardiovascular death worldwide. Complications from VT and pulmonary embolism are the leading cause of…”
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The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits by Byrnes, James R., Wilson, Clare, Boutelle, Anthony M., Brandner, Chase B., Flick, Matthew J., Philippou, Helen, Wolberg, Alisa S.

“…Coagulation transglutaminase factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A2B2. Effectively all FXIII-A2B2 circulates bound to…”
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Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration by Byrnes, James R, Lee, Taek, Sharaby, Sherif, Campbell, Robert A, Dobson, Dre'Von A, Holle, Lori A, Luo, Michelle, Kangro, Kadri, Homeister, Jonathon W, Aleman, Maria M, Luyendyk, James P, Kerlin, Bryce A, Dumond, Julie B, Wolberg, Alisa S

“…Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers…”
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Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins by Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Yefet, Leeor S., Byrnes, James R., Ho, Laura, Yeon, Ju Hun, Filipenko, Sam, Wolberg, Alisa S., Jefferies, Wilfred A., Kastrup, Christian J.

“…In cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and…”
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