Search Results - "Byrne, Gerald I."

Chlamydia trachomatis Strains and Virulence: Rethinking Links to Infection Prevalence and Disease Severity by Byrne, Gerald I.

“…An unanswered question concerning prevalence and disease severity of Chlamydia trachomatis genital infection is whether more prevalent strains or strains more…”
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Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2 by Cao, Fei, Castrillo, Antonio, Tontonoz, Peter, Re, Fabio, Byrne, Gerald I

“…Chlamydia pneumoniae induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (LDL). This study…”
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Chlamydia trachomatis growth depends on eukaryotic cholesterol esterification and is affected by Acyl-CoA:cholesterol acyltransferase inhibition by Peters, Jan, Byrne, Gerald I.

“…Chlamydia trachomatis is auxotrophic for a variety of essential metabolites. Inhibitors that interrupt host cell catabolism may inhibit chlamydial growth and…”
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Summary: The Natural History and Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia Control by Gottlieb, Sami L., Martin, David H., Xu, Fujie, Byrne, Gerald I., Brunham, Robert C.

“…In 2008, the US Centers for Disease Control and Prevention held the Chlamydia Immunology and Control Expert Advisory Meeting to foster a dialogue among basic…”
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Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence by Bonner, Carol A, Byrne, Gerald I, Jensen, Roy A

“…We previously proposed that in Chlamydiaceae rapid vegetative growth and a quiescent state of survival (persistence) depend upon alternative protein…”
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Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms by Miyairi, Isao, Ziebarth, Jesse, Laxton, Jonathan D, Wang, Xiaofei, van Rooijen, Nico, Williams, Robert W, Lu, Lu, Byrne, Gerald I, Cui, Yan

“…Genetic mapping studies may provide association between sequence variants and disease susceptibility that can, with further experimental and computational…”
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The p47 GTPases Iigp2 and Irgb10 Regulate Innate Immunity and Inflammation to Murine Chlamydia psittaci Infection by Miyairi, Isao, Tatireddigari, Venkat R. R. Arva, Mahdi, Olaimatu S, Rose, Lorne A, Belland, Robert J, Lu, Lu, Williams, Robert W, Byrne, Gerald I

“…C57BL/6J mice were 10(5)-fold more resistant to Chlamydia psittaci infection than DBA/2J mice by LD(100) determinations. Linkage analysis using BXD recombinant…”
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Introduction: The Natural History and Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia Control by Gottlieb, Sami L., Brunham, Robert C., Byrne, Gerald I., Martin, David H., Xu, Fujie, Berman, Stuart M.

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Induction of Macrophage Foam Cell Formation by Chlamydia pneumoniae by Kalayoglu, Murat V., Byrne, Gerald I.

“…Foam cell formation is the hallmark of early atherosclerosis. It was found that the intracellular bacterium Chlamydia pneumoniae induces foam cell formation by…”
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Different Growth Rates of Chlamydia trachomatis Biovars Reflect Pathotype by Miyairi, Isao, Mahdi, Olaimatu S., Ouellette, Scot P., Belland, Robert J., Byrne, Gerald I.

“…BackgroundDespite small genomic differences, Chlamydia trachomatis biovars exhibit diverse disease manifestations and different growth rates in vivo and in…”
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Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism by Abdelsamed, Hossam, Peters, Jan, Byrne, Gerald I

“…Chlamydia trachomatis infections are a global health problem. This obligate intracellular bacterial pathogen comprises lymphogranuloma venereum (L1-L3), ocular…”
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Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection by SAKASH, Jessica B, BYRNE, Gerald I, LICHTMAN, Andrew, LIBBY, Peter

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Chlamydia pneumoniae Expresses Genes Required for DNA Replication but Not Cytokinesis during Persistent Infection of HEp-2 Cells by BYRNE, Gerald I, OUELLETTE, Scot P, ZHAO WANG, RAO, J. P, LIN LU, BEATTY, Wandy L, HUDSON, Alan P

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The Chlamydia pneumoniae Type III Secretion-Related lcrH Gene Clusters Are Developmentally Expressed Operons by Ouellette, Scot P, Abdelrahman, Yasser M, Belland, Robert J, Byrne, Gerald I

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Chlamydial Virulence Determinants in Atherogenesis: The Role of Chlamydial Lipopolysaccharide and Heat Shock Protein 60 in Macrophage-Lipoprotein Interactions by Kalayoglu, Murat V., Indrawati, Morrison, Richard P., Morrison, Sandra G., Yuan, Ying, Byrne, Gerald I.

“…Data from a spectrum of epidemiologic, pathologic, and animal model studies show that Chlamydia pneumoniae infection is associated with coronary artery…”
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Chlamydia Uncloaked by Byrne, Gerald I.

“…The term was coined based on the incorrect conclusion that Chlamydia are intracellular protozoan pathogens that appear to cloak the nucleus of infected cells…”
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Chlamydia trachomatis Persistence in the Female Mouse Genital Tract: Inducible Nitric Oxide Synthase and Infection Outcome by RAMSEY, Kyle H, MIRANPURI, Gurwattan S, SIGAR, Ira M, OUELLETTE, Scott, BYRNE, Gerald I

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Chlamydia and apoptosis: life and death decisions of an intracellular pathogen by Byrne, Gerald I, Ojcius, David M

“…The chlamydiae are important obligate intracellular prokaryotic pathogens that, each year, are responsible for millions of human infections involving the eye,…”
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Chlamydia pneumoniae as an Emerging Risk Factor in Cardiovascular Disease by Kalayoglu, Murat V, Libby, Peter, Byrne, Gerald I

“…Recent appreciation of atherosclerosis as a chronic, inflammatory disease has rekindled efforts to examine the role that infectious agents may play in…”
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Analysis of CPAF mutants: new functions, new questions (The ins and outs of a chlamydial protease) by Bavoil, Patrik M., Byrne, Gerald I.

“…Abstract The role of the chlamydial protease CPAF, previously described as a secreted serine protease processing a wealth of host and chlamydial proteins to…”
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