Search Results - "Byrne, Annette"

Challenging the status quo to improve the translational potential of preclinical oncology studies by Connor, Kate, Golebiewska, Anna, Byrne, Annette T

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Patient-derived xenograft models: an emerging platform for translational cancer research by Hidalgo, Manuel, Amant, Frederic, Biankin, Andrew V, Budinská, Eva, Byrne, Annette T, Caldas, Carlos, Clarke, Robert B, de Jong, Steven, Jonkers, Jos, Mælandsmo, Gunhild Mari, Roman-Roman, Sergio, Seoane, Joan, Trusolino, Livio, Villanueva, Alberto

“…Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research…”
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Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy by O'Connor, Aisling E., Gallagher, William M., Byrne, Annette T.

“…Photodynamic therapy (PDT) is now a well‐recognized modality for the treatment of cancer. While PDT has developed progressively over the last century, great…”
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Therapeutic Targeting of the Colorectal Tumor Stroma by Fridman, Wolf H., Miller, Ian, Sautès-Fridman, Catherine, Byrne, Annette T.

“…Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor…”
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Precision Therapy in RAS Mutant Colorectal Cancer by Dienstmann, Rodrigo, Connor, Kate, Byrne, Annette T., Fridman, W.H., Lambrechts, D., Sadanandam, A., Trusolino, L., Prehn, J.H.M., Tabernero, J., Kolch, W.

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AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection by Rudolph, Marion, Anzeneder, Tobias, Schulz, Anke, Beckmann, Georg, Byrne, Annette T, Jeffers, Michael, Pena, Carol, Politz, Oliver, Köchert, Karl, Vonk, Richardus, Reischl, Joachim

“…The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise…”
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AKT1E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection by Rudolph, Marion, Anzeneder, Tobias, Schulz, Anke, Beckmann, Georg, Byrne, Annette T, Jeffers, Michael, Pena, Carol, Politz, Oliver, Köchert, Karl, Vonk, Richardus, Reischl, Joachim

“…Background The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However,…”
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Bioluminescent imaging: a critical tool in pre-clinical oncology research by O'Neill, Karen, Lyons, Scott K, Gallagher, William M, Curran, Kathleen M, Byrne, Annette T

“…Bioluminescent imaging (BLI) is a non-invasive imaging modality widely used in the field of pre-clinical oncology research. Imaging of small animal tumour…”
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Perceptions of the impact of introducing administrative support for nurse unit managers: A qualitative evaluation by El Haddad, May, Wilkinson, Graham, Thompson, Lorraine, Faithfull‐Byrne, Annette, Moss, Cheryle

“…Aim To evaluate the impacts of introducing administrative support for nurse unit managers. Background Increased administrative load for nurse unit managers…”
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OBSERVE: guidelines for the refinement of rodent cancer models by De Vleeschauwer, Stéphanie I., van de Ven, Marieke, Oudin, Anaïs, Debusschere, Karlijn, Connor, Kate, Byrne, Annette T., Ram, Doreen, Rhebergen, Anne Marie, Raeves, Yannick D., Dahlhoff, Maik, Dangles-Marie, Virginie, Hermans, Els R.

“…Existing guidelines on the preparation (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence (PREPARE)) and reporting…”
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A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring by Connor, Kate, Conroy, Emer, White, Kieron, Shiels, Liam P., Keek, Simon, Ibrahim, Abdalla, Gallagher, William M., Sweeney, Kieron J., Clerkin, James, O’Brien, David, Cryan, Jane B., O’Halloran, Philip J., Heffernan, Josephine, Brett, Francesca, Lambin, Philippe, Woodruff, Henry C., Byrne, Annette T.

“…Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted…”
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Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer by Jarzabek, Monika A, Proctor, William R, Vogt, Jennifer, Desai, Rupal, Dicker, Patrick, Cain, Gary, Raja, Rajiv, Brodbeck, Jens, Stevens, Dale, van der Stok, Eric P, Martens, John W M, Verhoef, Cornelis, Hegde, Priti S, Byrne, Annette T, Tarrant, Jacqueline M

“…Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal…”
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BF2-Azadipyrromethene Fluorophores for Intraoperative Vital Structure Identification by Caulfield, Cathal, Wu, Dan, Miller, Ian S., Byrne, Annette T., Mac Aonghusa, Pól, Zhuk, Sergiy, Cinelli, Lorenzo, Bannone, Elisa, Marescaux, Jacques, Gioux, Sylvain, Diana, Michele, March, Taryn L., Vahrmeijer, Alexander L., Cahill, Ronan, O’Shea, Donal F.

“…A series of mono- and bis-polyethylene glycol (PEG)-substituted BF2-azadipyrromethene fluorophores have been synthesized with emissions in the near-infrared…”
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Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents by Netufo, Oluwakanyinsolami, Connor, Kate, Shiels, Liam P, Sweeney, Kieron J, Wu, Dan, O'Shea, Donal F, Byrne, Annette T, Miller, Ian S

“…Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26-33%. Maximal safe resection plays a crucial role in…”
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Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells by Fabro, Federica, Kers, Trisha V., Feller, Kate J., Beerens, Cecile, Ntafoulis, Ioannis, Idbaih, Ahmed, Verreault, Maite, Connor, Kate, Biswas, Archita, Salvucci, Manuela, Prehn, Jochen H. M., Byrne, Annette T., O’Farrell, Alice C., Lambrechts, Diether, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, Kremer, Andreas, Tching Chi Yen, Romain, Chien, Miao-Ping, Lamfers, Martine L. M., Leenstra, Sieger

“…Chemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the…”
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Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer by Lafferty, Adam, O'Farrell, Alice C, Migliardi, Giorgia, Khemka, Niraj, Lindner, Andreas U, Sassi, Francesco, Zanella, Eugenia R, Salvucci, Manuela, Vanderheyden, Evy, Modave, Elodie, Boeckx, Bram, Halang, Luise, Betge, Johannes, Ebert, Matthias P A, Dicker, Patrick, Argilés, Guillem, Tabernero, Josep, Dienstmann, Rodrigo, Medico, Enzo, Lambrechts, Diether, Bertotti, Andrea, Isella, Claudio, Trusolino, Livio, Prehn, Jochen H M, Byrne, Annette T

“…Regorafenib (REG) is approved for the treatment of metastatic colorectal cancer, but has modest survival benefit and associated toxicities. Robust…”
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The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy? by Joerger, Markus, Finn, Stephen P, Cuffe, Sinead, Byrne, Annette T, Gray, Steven G

“…There is strong pharmaceutical development of agents targeting the IL-17-TH17 pathway for the treatment of psoriasis (Ps) and psoriatic arthritis (PsA). Lung…”
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Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers by Ntafoulis, Ioannis, Kleijn, Anne, Ju, Jie, Jimenez-Cowell, Kevin, Fabro, Federica, Klein, Michelle, Chi Yen, Romain Tching, Balvers, Rutger K., Li, Yunlei, Stubbs, Andrew P., Kers, Trisha V., Kros, Johan M., Lawler, Sean E., Beerepoot, Laurens V., Kremer, Andreas, Idbaih, Ahmed, Verreault, Maite, Byrne, Annette T., O’Farrell, Alice C., Connor, Kate, Biswas, Archita, Salvucci, Manuela, Prehn, Jochen H. M., Lambrechts, Diether, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, van den Bent, Martin J., Dirven, Clemens M. F., Leenstra, Sieger, Lamfers, Martine L. M.

“…Background Patient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be established…”
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Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors by RANI, Sweta, CORCORAN, Claire, GOGARTY, Martina, BYRNE, Annette T, O'DRISCOLL, Lorraine, SHIELS, Liam, GERMANO, Serena, BRESLIN, Susan, MADDEN, Stephen, MCDERMOTT, Martina S, BROWNE, Brigid C, O'DONOVAN, Norma, CROWN, John

“…Intrinsic and acquired resistance to HER-targeting drugs occurs in a significant proportion of HER2-overexpressing breast cancers. Thus, there remains a need…”
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Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab by van Dijk, Erik, Biesma, Hedde D, Cordes, Martijn, Smeets, Dominiek, Neerincx, Maarten, Das, Sudipto, Eijk, Paul P, Murphy, Verena, Barat, Anna, Bacon, Orna, Prehn, Jochen H M, Betge, Johannes, Gaiser, Timo, Fender, Bozena, Meijer, Gerrit A, McNamara, Deborah A, Klinger, Rut, Koopman, Miriam, Ebert, Matthias P A, Kay, Elaine W, Hennessey, Bryan T, Verheul, Henk M W, Gallagher, William M, O'Connor, Darran P, Punt, Cornelis J A, Loupakis, Fotios, Lambrechts, Diether, Byrne, Annette T, van Grieken, Nicole C T, Ylstra, Bauke

“…Purpose Patients with metastatic colorectal cancer (mCRC) have limited benefit from the addition of bevacizumab to standard chemotherapy. However, a subset…”
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