The use of the deuterated internal standard for morphine quantitation for the purpose of doping control by gas chromatography with mass-selective detection

The objective of this study was to demonstrate the possibility to use deuterated compounds as internal standards for the quantitative analysis of morphine by gas chromatography with mass-selective detection for the purpose of doping control. The paper is focused on the problems associated with the u...

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Bibliographic Details
Published in:	Sudebno-meditsinskaia ekspertiza Vol. 53; no. 3; p. 29
Main Authors:	Savel'eva, N B, Bykovskaia, N Iu, Dikunets, M A, Bolotov, S L, Rodchenkov, G M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2010
Subjects:	Analgesics, Opioid - analysis Deuterium - analysis Deuterium - chemistry Doping in Sports - prevention & control Gas Chromatography-Mass Spectrometry - methods Humans Morphine - analysis Reference Standards
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Summary:	The objective of this study was to demonstrate the possibility to use deuterated compounds as internal standards for the quantitative analysis of morphine by gas chromatography with mass-selective detection for the purpose of doping control. The paper is focused on the problems associated with the use of deuterated morphine-D3 as the internal standard. Quantitative characteristics of the calibration dependence thus documented are presented along with uncertainty values obtained in the measurements with the use of deuterated morphine-D6. An approach to the assessment of method bias associated with the application of morphine-D6 as the deuterated internal standard is described.
ISSN:	0039-4521