Search Results - "Bygrave, Anne E."

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H by Botto, Marina, Pickering, Matthew C, Cook, H. Terence, Warren, Joanna, Bygrave, Anne E, Moss, Jill, Walport, Mark J

“…The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is triggered by the hydrolysis of C3,…”
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Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice by Rose, Kirsten L, Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P, Malik, Talat H, Bygrave, Anne E, Lin, Tao, Sacks, Steven H, Walport, Mark J, Cook, H Terence, Botto, Marina, Pickering, Matthew C

“…The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of…”
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Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice by Bygrave, Anne E, Rose, Kirsten L, Cortes-Hernandez, Josefina, Warren, Joanna, Rigby, Robert J, Cook, H Terence, Walport, Mark J, Vyse, Timothy J, Botto, Marina

“…Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of…”
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Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice by Carlucci, Francesco, Cortes-Hernandez, Josefina, Fossati-Jimack, Liliane, Bygrave, Anne E, Walport, Mark J, Vyse, Timothy J, Cook, H. Terence, Botto, Marina

“…Extensive evidence indicates that genetic predisposition is a central element in susceptibility to systemic lupus erythematosus both in humans and animals. We…”
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Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria by Holt, Dewi S., Botto, Marina, Bygrave, Anne E., Hanna, S. Melanie, Walport, Mark J., Morgan, B. Paul

“…The glycolipid-anchored glycoprotein CD59 inhibits assembly of the lytic membrane attack complex of complement by incorporation into the forming complex…”
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Cutting Edge: C1q Protects Against the Development of Glomerulonephritis Independently of C3 Activation by Mitchell, Daniel A, Taylor, Philip R, Cook, H. Terence, Moss, Jill, Bygrave, Anne E, Walport, Mark J, Botto, Marina

“…C1q-deficient (C1qa-/-) mice develop antinuclear Abs and glomerulonephritis (GN) characterized by multiple apoptotic bodies. To explore the contribution of C3…”
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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies by Botto, Marina, Dell' Agnola, Chiara, Bygrave, Anne E, Thompson, E. Mary, Cook, H. Terence, Petry, Franz, Loos, Michael, Pandolfi, Pier Paolo, Walport, Mark J

“…The complement system plays a paradoxical role in the development and expression of autoimmunity in humans. The activation of complement in systemic lupus…”
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Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis by Norsworthy, Peter J, Fossati-Jimack, Liliane, Cortes-Hernandez, Josefina, Taylor, Philip R, Bygrave, Anne E, Thompson, Richard D, Nourshargh, Sussan, Walport, Mark J, Botto, Marina

“…Human CD93 (known as C1qRp) has been shown to be a phagocytic receptor involved in the in vitro C1q-dependent enhancement of phagocytosis. However, binding of…”
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Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene by Botto, Marina, Hawkins, Philip N, Bickerstaff, Maria C.M, Herbert, Jeff, Bygrave, Anne E, Mcbride, Alan, Hutchinson, Winston L, Tennent, Glenys A, Walportz, Mark J, Pepys, Mark B

“…The tissue amyloid deposits that characterize systemic amyloidosis, Alzheimer's disease and the transmissible spongiform encephalopathies always contain serum…”
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Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice by Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat, Bygrave, Anne E., Lin, Tao, Sacks, Steven H., Walport, Mark J., Cook, H. Terence, Botto, Marina, Pickering, Matthew C.

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Altered major histocompatibility complex class II peptide loading in H2‐O‐deficient mice by Perraudeau, Mohini, Taylor, Philip R., Stauss, Hans J., Lindstedt, Ragnar, Bygrave, Anne E., Pappin, Darryl J. C., Ellmerich, Stephan, Whitten, Angela, Rahman, Dinah, Canas, Benito, Walport, Mark J., Botto, Marina, Altmann, Daniel M.

“…The biosynthesis of MHC class II/peptide complexes involves classical, cell surface MHC products as well as the intracellular component H2‐M, required for the…”
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A Targeted Disruption of the Murine Complement Factor B Gene Resulting in Loss of Expression of Three Genes in Close Proximity, Factor B, C2, and D17H6S45 by Taylor, Philip R., Nash, Julian T., Theodoridis, Efstathios, Bygrave, Anne E., Walport, Mark J., Botto, Marina

“…Factor B is a serine protease, essential for the function of the alternative pathway of complement activation. To study further the importance of the…”
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Knocking out mouse CD59 using a PCR derived gene targeting vector by Holt, Dewi S., Botto, Marina, Bygrave, Anne E., Rushmere, Neil K., Walport, Mark J., Paul Morgan, B.

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