Search Results - "Byersdorfer, Craig"

Targeting immuno-metabolism to improve anti-cancer therapies by Beezhold, Kevin, Byersdorfer, Craig A.

“…The immunology community has made significant strides in recent years in using the immune system to target and eliminate cancer. Therapies such as…”
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Fatty acid oxidation in immune function by Kemp, Felicia, Braverman, Erica L, Byersdorfer, Craig A

“…Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive studies have demonstrated that metabolic decisions influence immune…”
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Metabolic Pathways in Alloreactive T Cells by Brown, Rebecca A, Byersdorfer, Craig A

“…Allogeneic hematopoietic stem cell transplantation (aHSCT) is a curative therapy for a range of hematologic illnesses including aplastic anemia, sickle cell…”
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Effector T cells require fatty acid metabolism during murine graft-versus-host disease by Byersdorfer, Craig A., Tkachev, Victor, Opipari, Anthony W., Goodell, Stefanie, Swanson, Jacob, Sandquist, Stacy, Glick, Gary D., Ferrara, James L.M.

“…Activated T cells require increased energy to proliferate and mediate effector functions, but the metabolic changes that occur in T cells following stimulation…”
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Programmed death-1 controls T cell survival by regulating oxidative metabolism by Tkachev, Victor, Goodell, Stefanie, Opipari, Anthony W, Hao, Ling-Yang, Franchi, Luigi, Glick, Gary D, Ferrara, James L M, Byersdorfer, Craig A

“…The coinhibitory receptor programmed death-1 (PD-1) maintains immune homeostasis by negatively regulating T cell function and survival. Blockade of PD-1…”
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Immunometabolism in haematopoietic stem cell transplantation and adoptive cellular therapies by Braverman, Erica L., Waltz, Gail, Byersdorfer, Craig A.

“…Controlling T cell activity through metabolic manipulation has become a prominent feature in immunology and practitioners of both adoptive cellular therapy…”
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The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source by Wen, Li, Javed, Tanveer A., Dobbs, Andrea K., Brown, Rebecca, Niu, Mengya, Li, Liwen, Khalid, Asna, Barakat, Monique T., Xiao, Xiangwei, Yimlamai, Dean, Konnikova, Liza, Yu, Mang, Byersdorfer, Craig A., Husain, Sohail Z.

“…Calcineurin is a ubiquitously expressed central Ca2+-responsive signaling molecule that mediates acute pancreatitis, but little is known about its effects. We…”
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Editorial: Beyond Histocompatibility - Understanding the Non-MHC Determinants Shaping Transplantation Outcome and Tolerance Induction by Byersdorfer, Craig A, Turnquist, Hēth R

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Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function by Braverman, Erica L, McQuaid, Margaret A, Schuler, Herbert, Qin, Mengtao, Hani, Sophia, Hippen, Keli, Monlish, Darlene A, Dobbs, Andrea K, Ramsey, Manda J, Kemp, Felicia, Wittmann, Christopher, Ramgopal, Archana, Brown, Harrison, Blazar, Bruce, Byersdorfer, Craig A

“…Cellular therapies are currently employed to treat a variety of disease processes. For T cell-based therapies, success often relies on the metabolic fitness of…”
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234 Metabolic enhancement of alternately co-stimulated CART cells through AMPK creates functionally distinct phenotypes by Braverman, Erica, Qin, Mengtao, Schuler, Herbert, Byersdorfer, Craig

“…BackgroundChimeric antigen receptor (CAR) T cells have significantly improved our ability to treat cancer. However, these therapies suffer from metabolic and…”
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Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma by Dolezal, James M., Wang, Huabo, Kulkarni, Sucheta, Jackson, Laura, Lu, Jie, Ranganathan, Sarangarajan, Goetzman, Eric S., Bharathi, Sivakama S., Beezhold, Kevin, Byersdorfer, Craig A., Prochownik, Edward V.

“…Hepatocellular carcinoma (HCC) is a common cancer that frequently overexpresses the c-Myc (Myc) oncoprotein. Using a mouse model of Myc-induced HCC, we studied…”
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Terminally exhausted CD8 + T cells contribute to age-dependent severity of respiratory virus infection by Parks, Olivia B, Eddens, Taylor, Sojati, Jorna, Lan, Jie, Zhang, Yu, Oury, Tim D, Ramsey, Manda, Erickson, John J, Byersdorfer, Craig A, Williams, John V

“…Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory…”
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Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease by Glick, Gary D, Rossignol, Rodrigue, Lyssiotis, Costas A, Wahl, Daniel, Lesch, Charles, Sanchez, Brian, Liu, Xikui, Hao, Ling-Yang, Taylor, Clarke, Hurd, Alexander, Ferrara, James L M, Tkachev, Victor, Byersdorfer, Craig A, Boros, Laszlo, Opipari, Anthony W

“…T-cell activation requires increased ATP and biosynthesis to support proliferation and effector function. Most models of T-cell activation are based on in…”
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Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation by Wahl, Daniel R., Byersdorfer, Craig A., Ferrara, James L. M., Opipari Jr, Anthony W., Glick, Gary D.

“…Summary For several decades, it has been known that T‐cell activation in vitro leads to increased glycolytic metabolism that fuels proliferation and effector…”
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The role of AMP-activated protein kinase in GVHD-causing T cells by Ramgopal, Archana, Sun, Lee-Kai, Byersdorfer, Craig A

“…Allogeneic stem cell transplantation is a curative therapy for multiple hematologic disorders. However, this life-saving procedure is often complicated by…”
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Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction by Atibalentja, Danielle F, Byersdorfer, Craig A, Unanue, Emil R

“…Using hen egg-white lysozyme, the effect of blood proteins on CD4 thymic cells was examined. A small fraction of i.v. injected hen egg-white lysozyme rapidly…”
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Rethinking the paradigm: How comparative studies on fatty acid oxidation inform our understanding of T cell metabolism by Chiaranunt, Pailin, Ferrara, James L.M., Byersdorfer, Craig A.

“…•Alloreactive T cells during graft-versus-host disease increase their reliance on fatty acid oxidation.•Key pathways of FAO regulation are conserved across…”
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AMPK drives both glycolytic and oxidative metabolism in murine and human T cells during graft-versus-host disease by Ramgopal, Archana, Braverman, Erica L., Sun, Lee-Kai, Monlish, Darlene, Wittmann, Christopher, Kemp, Felicia, Qin, Mengtao, Ramsey, Manda J., Cattley, Richard, Hawse, William, Byersdorfer, Craig A.

“…•AMPK plays a key role in driving both and oxidative and glycolytic metabolism in T cells during GVHD.•Absence of AMPK simultaneously impairs both glycolytic…”
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106 Increasing AMPK activity in human T cells enhances memory subset formation without sacrificing in vitro expansion by Braverman, Erica, Dobbs, Andrea, Monlish, Darlene, Byersdorfer, Craig

“…BackgroundThe ideal adoptive cell therapy consists of memory-like T cells with enhanced oxidative potential. However, current expansion protocols drive T cells…”
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Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository by Saito, Toshie, Wei, Yue, Wen, Li, Srinivasan, Chaitanya, Wolthers, Benjamin O., Tsai, Cheng-Yu, Harris, Marian H., Stevenson, Kristen, Byersdorfer, Craig, Oparaji, Judy-April, Fernandez, Christian, Mukherjee, Amitava, Abu-El-Haija, Maisam, Agnihotri, Sameer, Schmiegelow, Kjeld, Showalter, Megan R., Fogle, Paul W., McCulloch, Scott, Contrepois, Kevin, Silverman, Lewis B., Ding, Ying, Husain, Sohail Z.

“…Introduction Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the…”
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