Search Results - "Byer, Stephanie"

4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation by KOHLI, Latika, KAZA, Niroop, CORIC, Tatjana, BYER, Stephanie J, BRASSIER, Nicole M, KLOCKE, Barbara J, BJORNSTI, Mary-Ann, CARROLL, Steven L, ROTH, Kevin A

“…Tamoxifen is widely used to treat estrogen receptor-positive breast cancer. Recent findings that tamoxifen and its derivative 4-hydroxytamoxifen (OHT) can…”
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Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades by Brosius, Stephanie N, Turk, Amy N, Byer, Stephanie J, Longo, Jody Fromm, Kappes, John C, Roth, Kevin A, Carroll, Steven L

“…ABSTRACTChemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen…”
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Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells by Brossier, Nicole M., Prechtl, Amanda M., Longo, Jody Fromm, Barnes, Stephen, Wilson, Landon S., Byer, Stephanie J., Brosius, Stephanie N., Carroll, Steven L.

“…Neurofibromin, the tumor suppressor encoded by the neurofibromatosis type 1 (NF1) gene, potentially suppresses the activation of H-Ras, N-Ras, and K-Ras…”
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Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis by Kazmi, Syed J, Byer, Stephanie J, Eckert, Jenell M, Turk, Amy N, Huijbregts, Richard P.H, Brossier, Nicole M, Grizzle, William E, Mikhail, Fady M, Roth, Kevin A, Carroll, Steven L

“…Patients with neurofibromatosis type 1 (NF1) develop benign plexiform neurofibromas that frequently progress to become malignant peripheral nerve sheath tumors…”
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Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis by Brosius, Stephanie N., Turk, Amy N., Byer, Stephanie J., Brossier, Nicole M., Kohli, Latika, Whitmire, Amber, Mikhail, Fady M., Roth, Kevin A., Carroll, Steven L.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are Schwann cell-derived malignancies that arise from plexiform neurofibromas in patients with mutation of…”
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Neuregulin-1β and neuregulin-1α differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells by Eckert, Jenell M., Byer, Stephanie J., Clodfelder-Miller, Buffie J., Carroll, Steven L.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are the most common malignancy associated with neurofibromatosis Type 1 (NF1). These Schwann cell…”
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Malignant Peripheral Nerve Sheath Tumor Invasion Requires Aberrantly Expressed EGF Receptors and Is Variably Enhanced by Multiple EGF Family Ligands by Byer, Stephanie J, Brossier, Nicole M, Peavler, Lafe T, Eckert, Jenell M, Watkins, Stacey, Roth, Kevin A, Carroll, Steven L

“…ABSTRACTAberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most…”
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Activation of the neuregulin-1 ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors by STONECYPHER, Mark S, BYER, Stephanie J, GRIZZLE, William E, CARROLL, Steven L

“…Patients with neurofibromatosis type 1 develop aggressive Schwann cell neoplasms known as malignant peripheral nerve sheath tumors (MPNSTs). Although tumor…”
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Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner by Byer, Stephanie J., Eckert, Jenell M., Brossier, Nicole M., Clodfelder-Miller, Buffie J., Turk, Amy N., Carroll, Andrew J., Kappes, John C., Zinn, Kurt R., Prasain, Jeevan K., Carroll, Steven L.

“…Few therapeutic options are available for malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy associated with neurofibromatosis type…”
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Neuregulin Growth Factors and Their ErbB Receptors Form a Potential Signaling Network for Schwannoma Tumorigenesis by Stonecypher, Mark S, Chaudhury, Abhik Ray, Byer, Stephanie J, Carroll, Steven L

“…Sporadic and neurofibromatosis type 2-associated schwannomas contain a glial growth factor (GGF)-like activity that has been hypothesized to promote neoplastic…”
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Orthotopic xenografting of human luciferase-tagged malignant peripheral nerve sheath tumor cells for in vivo testing of candidate therapeutic agents by Turk, Amy N, Byer, Stephanie J, Zinn, Kurt R, Carroll, Steven L

“…Although in vitro screens are essential for the initial identification of candidate therapeutic agents, a rigorous assessment of the drug's ability to inhibit…”
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Ganglion-Specific Patterns of Diabetes-Modulated Gene Expression Are Established in Prevertebral and Paravertebral Sympathetic Ganglia Prior to the Development of Neuroaxonal Dystrophy by CARROLL, STEVEN L, BYER, STEPHANIE J, DORSEY, DENISE A, WATSON, MARK A, SCHMIDT, ROBERT E

“…In both humans and animal models, diabetic sympathetic autonomic neuropathy is associated with the selective development of markedly enlarged distal axons and…”
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R‐Ras Subfamily Proteins Elicit Distinct Physiologic Effects and Phosphoproteome Alterations in Neurofibromin‐Null MPNST Cells by Prechtl, Amanda, Brossier, Nicole, Barnes, Stephen, Wilson, Landon, Brosius, Stephanie, Byer, Stephanie, Carroll, Steven

“…Abstract only Loss of the Ras GTPase‐activating protein neurofibromin promotes the development of multiple nervous system tumors in patients with the genetic…”
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Overexpression of the lysophosphatidic acid generating enzyme autotaxin/ENPP2 potentially promotes the pathogenesis of neurofibromatosis type 1‐associated neurofibromas and malignant peripheral nerve sheath tumors by Peavler, Lafe Timothy, Byer, Stephanie J., Roth, Kevin A., Carroll, Steven L.

“…Abstract only Aggressive Schwann cell‐derived sarcomas known as malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of death in patients…”
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LPA and NRG‐1b synergistically promote proliferation and migration of wild‐type and neoplastic Schwann cells via an ERRFI1‐dependent mechanism by Brossier, Nicole Marie, Byer, Stephanie, Carroll, Steven

“…Abstract only…”
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Neuregulin‐1 overexpression and p53 haploinsufficiency cooperatively promote de novo MPNST pathogenesis by Brosius, Stephanie Nicole, Turk, Amy Nicole, Byer, Stephanie Joy, Brossier, Nicole Marie, Kohli, Latika, Roth, Kevin Aaron, Carroll, Steven Lewis

“…Abstract only Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas arising from neurofibromas in patients with neurofibromatosis type 1…”
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Malignant Peripheral Nerve Sheath Tumor Invasion Requires Aberrantly Expressed Epidermal Growth Factor (EGF) Receptors and is Variably Enhanced by Multiple EGF Family Ligands by Byer, Stephanie J., Brossier, Nicole M., Peavler, Lafe T., Eckert, Jenell M., Watkins, Stacey, Roth, Kevin A., Carroll, Steven L.

“…Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common…”
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4-hydroxy-tamoxifen induces autophagic death through K-Ras degradation by Kohli, Latika, Kaza, Niroop, Coric, Tatjana, Byer, Stephanie J., Brossier, Nicole M., Klocke, Barbara J., Bjornsti, Mary-Ann, Carroll, Steven L., Roth, Kevin A.

“…Tamoxifen is widely used to treat estrogen receptor (ER)-positive breast cancer. Recent findings that tamoxifen and its derivative 4-dehydroxy-tamoxifen (OHT)…”
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Tamoxifen inhibits the proliferation and survival of malignant peripheral nerve sheath tumor cells via an estrogen receptor‐independent mechanism by Eckert, Jenell Marie, Byer, Stephanie, Prasain, Jeevan, Carroll, Steven

“…Abstract only…”
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Neuregulin-1b and neuregulin-1a differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells by Eckert, Jenell M, Byer, Stephanie J, Clodfelder-Miller, Buffie J, Carroll, Steven L

“…Malignant peripheral nerve sheath tumors (MPNSTs) are the most common malignancy associated with neurofibromatosis Type 1 (NF1). These Schwann cell…”
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