Search Results - "Bye, Alexander P."

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets by Bye, Alexander P., Hoepel, Willianne, Mitchell, Joanne L., Jégouic, Sophie, Loureiro, Silvia, Sage, Tanya, Vidarsson, Gestur, Nouta, Jan, Wuhrer, Manfred, de Taeye, Steven, van Gils, Marit, Kriek, Neline, Cooper, Nichola, Jones, Ian, den Dunnen, Jeroen, Gibbins, Jonathan M.

“…A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill, suffering from severe respiratory problems and also increased rates of…”
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Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib by Bye, Alexander P, Kriek, Neline, Sage, Tanya, Rawlings, Suzannah J, Prodger, Catherine, Kesavan, Murali, Lees, Charlotte, Booth, Stephen, Cowen, Louise G, Shefferd, Kirsty, Desborough, Michael J, Gibbins, Jonathan M, Eyre, Toby A

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RXR Ligands Negatively Regulate Thrombosis and Hemostasis by Unsworth, Amanda J, Flora, Gagan D, Sasikumar, Parvathy, Bye, Alexander P, Sage, Tanya, Kriek, Neline, Crescente, Marilena, Gibbins, Jonathan M

“…OBJECTIVE—Platelets have been found to express intracellular nuclear receptors including the retinoid X receptors (RXRα and RXRβ). Treatment of platelets with…”
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Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling by Unsworth, Amanda J, Bye, Alexander P, Sage, Tanya, Gaspar, Renato S, Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J, Hutchinson, James L, Riley, Ryan, Jones, Sarah, Mundell, Stuart J, Cui, Weiguo, Falet, Hervé, Gibbins, Jonathan M

“…Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and…”
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Multiple myeloma and its treatment contribute to increased platelet reactivity by Mitchell, Joanne L, Khan, Dalia, Rana, Rekha H, Kriek, Neline, Unsworth, Amanda J, Sage, Tanya, Bye, Alexander P, Laffan, Michael, Shapiro, Susan, Thakurta, Anjan, Grech, Henri, Ramasamy, Karthik, Gibbins, Jonathan M

“…Multiple myeloma (MM) and its precursor states, smoldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS) are associated with…”
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Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib by Bye, Alexander P., Unsworth, Amanda J., Desborough, Michael J., Hildyard, Catherine A.T., Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H., Sage, Tanya, Hughes, Craig E., Gibbins, Jonathan M.

“…The Bruton tyrosine kinase (Btk) inhibitor ibrutinib induces platelet dysfunction and causes increased risk of bleeding. Off-target inhibition of Tec is…”
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Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring by Gaspar, Renato S., Unsworth, Amanda J., Al-Dibouni, Alaa, Bye, Alexander P., Sage, Tanya, Stewart, Michelle, Wells, Sara, Cox, Roger D., Gibbins, Jonathan M., Sellayah, Dyan, E. Hughes, Craig

“…Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed,…”
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1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis by Alatawi, Kahdr A, Ravishankar, Divyashree, Patra, Pabitra H, Bye, Alexander P, Stainer, Alexander R, Patel, Ketan, Widera, Darius, Vaiyapuri, Sakthivel

“…1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole…”
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Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis by VAIYAPURI, Sakthivel, JONES, Chris I, STAIN, Christopher J, BYE, Alexander P, JONES, Sarah, OVIEDO-ORTA, Ernesto, SIMON, Alexander M, MAHAUT-SMITH, Martyn P, GIBBINS, Jonathan M, SASIKUMAR, Parvathy, MORAES, Leonardo A, MUNGER, Stephanie J, WRIGHT, Joy R, ALI, Marfoua S, SAGE, Tanya, KAISER, William J, TUCKER, Katherine L

“…Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane…”
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Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction by Unsworth, Amanda J., Bye, Alexander P., Kriek, Neline, Sage, Tanya, Osborne, Ashley A., Donaghy, Dillon, Gibbins, Jonathan M.

“…The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage…”
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The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects by Stainer, Alexander R, Sasikumar, Parvathy, Bye, Alexander P, Unsworth, Amanda J, Holbrook, Lisa M, Tindall, Marcus, Lovegrove, Julie A, Gibbins, Jonathan M

“…Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in…”
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Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen by Bye, Alexander P, Unsworth, Amanda J, Vaiyapuri, Sakthivel, Stainer, Alexander R, Fry, Michael J, Gibbins, Jonathan M

“…OBJECTIVE—Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia,…”
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Ca 2+ waves coordinate purinergic receptor-evoked integrin activation and polarization by Bye, Alexander P, Gibbins, Jonathan M, Mahaut-Smith, Martyn P

“…Cells sense extracellular nucleotides through the P2Y class of purinergic G protein-coupled receptors (GPCRs), which stimulate integrin activation through…”
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The rate of platelet activation determines thrombus size and structure at arterial shear by Mitchell, Joanne L., Dunster, Joanne L., Kriek, Neline, Unsworth, Amanda J., Sage, Tanya, Mohammed, Yasmin M.M., De Simone, Ilaria, Taylor, Kirk A., Bye, Alexander P., Ólafsson, Geir, Brunton, Mark, Mark, Sharon, Dymott, Leanne D., Whyte, Abigail, Ruparelia, Neil, Mckenna, Charlie, Gibbins, Jonathan M., Jones, Christopher I.

“…The response of platelets to activating stimuli and pharmaceutical agents varies greatly within the normal population. Current platelet function tests are used…”
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Screening and High-Throughput Platelet Assays by Bye, Alexander P, Unsworth, Amanda J, Gibbins, Jonathan M

“…High-throughput assays are important biological research tools but are rarely utilized for platelet research. However, screening compounds for efficacy against…”
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Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation by Dunster, Joanne L., Unsworth, Amanda J., Bye, Alexander P., Haining, Elizabeth J., Sowa, Marcin A., Di, Ying, Sage, Tanya, Pallini, Chiara, Pike, Jeremy A., Hardy, Alexander T., Nieswandt, Bernhard, García, Ángel, Watson, Steve P., Poulter, Natalie S., Gibbins, Jonathan M., Pollitt, Alice Y.

“…Background Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that…”
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Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets by Sahli, Khaled A., Flora, Gagan D., Sasikumar, Parvathy, Maghrabi, Ali H., Holbrook, Lisa-Marie, AlOuda, Sarah K., Elgheznawy, Amro, Sage, Tanya, Stainer, Alexander R., Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vaiyapuri, Sakthivel, Bye, Alexander P., Unsworth, Amanda J., Jones, Chris I., McGuffin, Liam J., Gibbins, Jonathan M.

“…Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and…”
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Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis by Bye, Alexander P, Ilkan, Zeki, Unsworth, Amanda J, Jones, Chris I

“…Existing methods for measuring the response of individual platelets to stimulation are limited. They either measure each platelet at one discrete time-point…”
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Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets by Unsworth, Amanda J, Bye, Alexander P, Tannetta, Dionne S, Desborough, Michael J.R, Kriek, Neline, Sage, Tanya, Allan, Harriet E, Crescente, Marilena, Yaqoob, Parveen, Warner, Timothy D, Jones, Chris I, Gibbins, Jonathan M

“…OBJECTIVES—The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to…”
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Multiparameter phenotyping of platelet reactivity for stratification of human cohorts by Dunster, Joanne L., Bye, Alexander P., Kriek, Neline, Sage, Tanya, Mitchell, Joanne L., Kempster, Carly, Batista, Joana, McKinney, Harriet, Thomas, Patrick, Jones, Chris I., Downes, Kate, Unsworth, Amanda J., Gibbins, Jonathan M.

“…Accurate and comprehensive assessment of platelet function across cohorts of donors may be key to understanding the risk of thrombotic events associated with…”
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