Search Results - "Bwayi, Monicah N"

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR by Huber, Andrew D, Poudel, Shyaron, Wu, Jing, Miller, Darcie J, Lin, Wenwei, Yang, Lei, Bwayi, Monicah N, Rimmer, Mary Ashley, Gee, Rebecca R Florke, Seetharaman, Jayaraman, Chai, Sergio C, Chen, Taosheng

“…Abstract Bromodomain and extraterminal (BET) proteins are extensively studied in multiple pathologies, including cancer. BET proteins modulate transcription of…”
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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation by Bwayi, Monicah N, Garcia-Maldonado, Efren, Chai, Sergio C, Xie, Boer, Chodankar, Shirish, Huber, Andrew D, Wu, Jing, Annu, Kavya, Wright, William C, Lee, Hyeong-Min, Seetharaman, Jayaraman, Wang, Jingheng, Buchman, Cameron D, Peng, Junmin, Chen, Taosheng

“…Abstract The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes…”
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A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology by Van Sciver, Robert E, Lee, Michael P, Lee, Caroline Dasom, Lafever, Alex C, Svyatova, Elizaveta, Kanda, Kevin, Colliver, Amber L, Siewertsz van Reesema, Lauren L, Tang-Tan, Angela M, Zheleva, Vasilena, Bwayi, Monicah N, Bian, Minglei, Schmidt, Rebecca L, Matrisian, Lynn M, Petersen, Gloria M, Tang, Amy H

“…Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer…”
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